Results 31 to 40 of about 98,896 (358)

長期間喫煙による気管支唱息,肺気腫の病態的変化 [PDF]

, 2004
The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1.
Ashida, Kozo, Fujii, Makoto, Hamada, Masanori, Hosaki, Yasuhiro, Iwagaki, Naofumi, Mitsunobu, Fumihiro, Takata, Shingo, Tanizaki, Yoshiro   +7 more
core   +1 more source

Zileuton protects against arachidonic acid/5-lipoxygenase/leukotriene axis-mediated neuroinflammation in experimental traumatic brain injury

Frontiers in Pharmacology
IntroductionTraumatic brain injury (TBI) is a leading cause of death and disability globally. Several studies have shown that 5-lipoxygenase (5-LOX) inhibition reduces leukotriene (LT) release and the inflammatory response, attenuating the development of
Xiaofeng Xu, Yan Wang, Xiaomei Li, Yang Yang, Dianxu Yang, Wenqi Tang, Jin Lu, Fang Yuan   +7 more
doaj   +1 more source

miRNAs and Leukotrienes in Respiratory Syncytial Virus Infection

Frontiers in Pediatrics, 2021
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate posttranscription by binding to 3′-untranslated regions of target mRNAs. Recent functional studies have elucidated mechanisms that miRNAs regulate leukotriene synthesis by perturbing arachidonic
Zhi Liu, Panpan Fan, Ming Chen, Ming Chen, Yueshi Xu, Dongchi Zhao   +5 more
doaj   +1 more source

Effect of a leukotriene receptor antagonist pranlukast hydrate, on airway inflammation airway hyperresponsiveness in patients with moderate to severe asthma

Allergology International, 2000
Asthma is characterized by chronic airway inflammation and the recruitment of inflammatory cells, typically eosinophils and lymphocytes, into the airway. Although several chemical mediators are released during the inflammatory process of asthma, evidence
Kiyoko Wada, Kenji Minoguchi, Yasurou Kohno, Naruhito Oda, Takayuki Matsuura, Kenta Kawazu, Masatsugu Kurokawa, Takeshi Tomita, Kana Ueno, Fumio Kokubu, Shunichi Mita, Mitsuru Adachi   +11 more
doaj   +1 more source

Virtual screening for NS5B inhibitors of Hepatitis C virus [PDF]

, 2012
Hepatitis C Virus (HCV) infection is a serious cause of chronic liver disease worldwide with more than 170 million infected individuals at a risk of developing significant morbidity and mortality.
Achuthsankar S. Nair, Amjesh R, Sugunan V.S.   +2 more
core   +2 more sources

Cysteinyl leukotrienes pathway genes, atopic asthma and drug response: From population isolates to large genome-wide association studies.

Frontiers in Pharmacology, 2016
Genetic studies have identified genetic variants associated with asthma pathogenesis and altered response to drug therapy. Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene synthesis and intracellular ...
Miles Douglas Thompson, Valeri Capra, Mark Clunes, G. Enrico Rovati, Mary Maj, Jana Stankova, David Duffy   +6 more
doaj   +1 more source

Real-world research and its importance in respiratory medicine [PDF]

, 2015
Peer reviewedPublisher ...
Brusselle, Guy, Chisholm, Alison, Freeman, Daryl, Price, David, Roche, Nicolas   +4 more
core   +6 more sources

Mitochondria-targeted antioxidant SkQ1 inhibits leukotriene synthesis in human neutrophils

Frontiers in Pharmacology, 2022
Leukotrienes are among the most potent mediators of inflammation, and inhibition of their biosynthesis, is becoming increasingly important in the treatment of many pathologies.
Galina F. Sud’ina, Ekaterina A. Golenkina, Anastasia S. Prikhodko, Natalia D. Kondratenko, Tatjana V. Gaponova, Boris V. Chernyak   +5 more
doaj   +1 more source

Concentrations of Cysteinyl Leukotrienes in Various Biological Fluids of Children with Bronchial Asthma, Atopic Dermatitis and Food Protein Induced Enterocolitis [PDF]

, 2019
Clinical manifestation of food allergy is characterized by polymorphic cutaneous, respiratory and gastrointestinal syndromes. Leukotrienes occupy a key place in the pathogenesis of a wide range of inflammatory diseases, including bronchial asthma ...
Haiduchyk, H. (Halyna), Shadrin, O. (Oleg)   +1 more
core   +3 more sources

Is there a rationale and role for long-acting anticholinergic bronchodilators in asthma? [PDF]

, 2014
The authors acknowledge the medical writing assistance received from Sam Yarwood, PhD, of Complete HealthVizion, in the form of literature searches and preparation and revision of the draft manuscript.Peer reviewedPublisher ...
Fromer, Leonard, Kaplan, Alan, Price, David, Román-Rodríguez, Miguel, van der Molen, Thys   +4 more
core   +8 more sources