Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease [PDF]
, 2019 BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives.
Antunes, A +7 more
core +1 more source
Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]
, 2013 Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A +2 more
core +2 more sources
Protective effect of leukotriene receptor antagonist montelukast on smoking-induced lung injury in Wistar rats. [PDF]
, 2003 Increased activation of alveolar macrophage, neutrophil and mast cell has been proven in cigarette smoking (CS)-related lung disorders (CSLD). An increased production of cysteinyl-leukotrienes (LTs), which are mediators secreted from the mentioned cells,
Coskun, Senol +3 more
core +1 more source
Circulating leukotriene b4 identifies respiratory complications after trauma [PDF]
, 2012 Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker ...
Auner, Birgit +5 more
core +1 more source
5-Lipoxygenase: mechanisms of regulation1
Journal of Lipid Research, 2009 5-Lipoxygenase (5-LO) catalyzes two steps in biosynthesis of leukotrienes (LTs), a group of lipid mediators of inflammation derived from arachidonic acid (AA).
Olof Rådmark, Bengt Samuelsson
doaj +1 more source
A metabolome-wide case-control study of african american breast cancer patients
BMC Cancer, 2023 Background Breast cancer survivors face long-term sequelae compared to the general population, suggesting altered metabolic profiles after breast cancer.
Jiajun Luo +8 more
doaj +1 more source
Two Pfam protein families characterized by a crystal structure of protein lpg2210 from Legionella pneumophila. [PDF]
, 2013 BackgroundEvery genome contains a large number of uncharacterized proteins that may encode entirely novel biological systems. Many of these uncharacterized proteins fall into related sequence families. By applying sequence and structural analysis we hope
Aravind, L +11 more
core +2 more sources
On the cellular metabolism of the click chemistry probe 19-alkyne arachidonic acid[S]
Journal of Lipid Research, 2016 Alkyne and azide analogs of natural compounds that can be coupled to sensitive tags by click chemistry are powerful tools to study biological processes. Arachidonic acid (AA) is a FA precursor to biologically active compounds.
Philippe Pierre Robichaud +6 more
doaj +1 more source
Phase 2 trial of montelukast for prevention of pain in sickle cell disease. [PDF]
, 2020 Cysteinyl leukotrienes (CysLTs) are lipid mediators of inflammation. In patients with sickle cell disease (SCD), levels of CysLTs are increased compared with controls and associated with a higher rate of hospitalization for pain. We tested the hypothesis
Brandow, Amanda +9 more
core
The aryl hydrocarbon receptor regulates lipid mediator production in alveolar macrophages
Frontiers in Immunology, 2023 Allergic inflammation of the airways such as allergic asthma is a major health problem with growing incidence world-wide. One cardinal feature in severe type 2-dominated airway inflammation is the release of lipid mediators of the eicosanoid family that ...
Ann-Marie Maier +14 more
doaj +1 more source