Results 201 to 210 of about 12,151 (255)
Leukotriene Antagonists in Asthma
New England Journal of Medicine, 2011 Aim Cysteinyl leukotrienes are important pro-inflammatory mediators in the pathogenesis of asthma, while leukotriene C 4 synthase is a key enzyme in their biosynthesis. Our aim is to evaluate whether responsiveness to leukotriene receptor antagonists was determined by expression of the variant (C) or wild-type (A) polymorphism of this enzyme.
Lipworth, Brian, Jackson, Catherine
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Leukotriene-receptor antagonists
Lancet, The, 1999Leukotriene-receptor antagonists are the first novel class of antiasthma drugs to become available over the past three decades. They have an unique profile in that they are a hybrid of an anti-inflammatory and bronchodilator drug, and they can be taken as a tablet once or twice daily.
Brian J Lipworth
exaly +5 more sources
Pharmacological Research, 1999
The demonstration that leukotrienes, mainly cysteinyl leukotrienes, have biological properties relevant to the pathogenesis of asthma has stimulated the development of many therapeutic compounds to block these deleterious effects. Two main classes of leukotriene modulators have been developed: CysLT1 receptor antagonists and leukotriene synthesis ...
Philippe Devillier, P Devillier
exaly +3 more sources
The demonstration that leukotrienes, mainly cysteinyl leukotrienes, have biological properties relevant to the pathogenesis of asthma has stimulated the development of many therapeutic compounds to block these deleterious effects. Two main classes of leukotriene modulators have been developed: CysLT1 receptor antagonists and leukotriene synthesis ...
Philippe Devillier, P Devillier
exaly +3 more sources
Leukotriene antagonists and the Churg-Strauss syndrome
Seminars in Arthritis and Rheumatism, 2002Leukotriene antagonists (LTAs), or antileukotrienes, are a new group of anti-inflammatory drugs used for the treatment of asthma. They might substitute for or allow tapering of corticosteroids in asthmatic patients. These drugs have been associated with the development of Churg-Strauss syndrome (CSS), a rare form of vasculitic angiitis.
Ayman Tawil, Thurayya Arayssi
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Leukotriene antagonists in asthma
Journal of Paediatrics and Child Health, 2012 Craig Mellis
openaire +3 more sources
Leukotriene antagonists and synthesis inhibitors: New directions in asthma therapy
Journal of Allergy and Clinical Immunology, 1996 This article briefly reviews the advances in our understanding of asthma with a particular focus on the role of inflammation, before providing a concise overview of current knowledge of leukotrienes in the pathophysiology of the disease.
Stephen Holgate +2 more
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Pharmacology and safety of the leukotriene antagonists
Clinical Reviews in Allergy & Immunology, 1999 Lewis J. Smith
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Clinics in Liver Disease, 2003
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
openaire +2 more sources
Hepatotoxicity is the most common cause of fulminant hepatic failure in the United States and the main indication for market withdrawal of drugs. This condition has been increasingly recognized as a problem of enormous medical, financial legal, and regulatory importance.
Timothy J, Davern, Nathan M, Bass
openaire +2 more sources