Results 211 to 220 of about 12,151 (255)

Leukotriene and thromboxane antagonists

Clinical Reviews in Allergy, 1994
It has been suggested that arachidonate metabolites, leukotrienes, and thromboxane may play important roles in the pathogenesis of bronchial asthma. Biologic activities of these mediators are much more potent than those of histamine and acetylcholine on a molar basis in inducing bronchoconstriction, increase in microvascular permeability, formation of ...
T, Obata, N, Yamashita, T, Nakagawa
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Anti-Allergic/Leukotriene Antagonists: Novel Benzophenone Derivatives as Potent Leukotriene Antagonists

Current Opinion on Therapeutic Patents, 1991
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Pharmacology of Leukotriene Receptor Antagonists

American Journal of Respiratory and Critical Care Medicine, 1998
Abstract Preclinical pharmacological studies have demonstrated that cysLT1 receptor antagonists, such as zafirlukast, montelukast, and pobilukast, are potent and selective antagonists of cysteinyl leukotriene (cysLT) activity. In vitro, these agents compete with [3H]LTD4 for binding to cysLT1 receptors present on guinea pig and human ...
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Leukotriene receptor antagonists - an update

Drug and Therapeutics Bulletin, 2005
Montelukast (Singulair - MSD) and zafirlukast (Accolate - AstraZeneca) are oral leukotriene receptor antagonists, licensed for the treatment of patients with asthma. In 1998, soon after their launch, we concluded that there was insufficient evidence to clearly define their place in treatment.1 Here, we reconsider their role in adults and children with ...
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Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation

Journal of Allergy and Clinical Immunology, 2003
The understanding that asthma pathophysiology includes an inflammatory component has spurred the more aggressive use of anti-inflammatory therapies and created a need for effective tools to measure inflammation. Biomarkers of airway inflammation proposed are obtained by methods that are direct but highly invasive (bronchial biopsy, bronchoalveolar ...
Sampson, Anthony P., Pizzichini, Emilio, Bisgaard, Hans   +2 more
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Phenylephrine derivatives as leukotriene D4 antagonists

Journal of Medicinal Chemistry, 1987
Two series of phenylephrine derivatives were prepared and tested as inhibitors of leukotriene D4 (LTD4) induced and ovalbumin-induced bronchospasm in the guinea pig. The most potent compound of the urea series, (R)-N,N-diethyl-N-[2-hydroxy-2-[3-(2-quinolinylmethoxy)phenyl]ethyl]-N- methylurea (3, Wy-47,120), was orally active with ED50's of 56 mg/kg vs.
J H, Musser, D M, Kubrak, R H, Bender, A F, Kreft, S T, Nielsen, A M, Lefer, J, Chang, A J, Lewis, J M, Hand   +8 more
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Leukotriene receptor antagonists in asthma therapy

Journal of Allergy and Clinical Immunology, 2003
In persons with asthma, the cysteinyl leukotrienes possess multiple inflammatory properties in vitro and have long been considered to be a potentially important mediator of asthma and an attractive target for therapeutic intervention. Controlled clinical trials have documented the efficacy of leukotriene receptor antagonists in asthma treatment, but ...
Peters, Stephen P., Hamid, Qutayba, Moqbel, Redwan, Sampson, Anthony, Peters-Golden, Marc, Leff, Jon, Pizzichini, Emilio, Edelman, Jon, Liu, Mark, Bisgaard, Hans, Henderson, Bill   +10 more
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Safety of leukotriene receptor antagonists in pregnancy

Journal of Allergy and Clinical Immunology, 2007
Asthma is a chronic disorder that affects about 8% of pregnant women and may complicate pregnancy. Adequate asthma therapy in pregnancy is crucial but challenging because of safety concerns for the fetus.To evaluate the safety of gestational asthma therapy with leukotriene receptor antagonists (LTRAs) for the mother and fetus/newborn.Subjects were ...
Ludmila N, Bakhireva, Kenneth Lyons, Jones, Michael, Schatz, Hillary S, Klonoff-Cohen, Diana, Johnson, Donald J, Slymen, Christina D, Chambers   +6 more
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[Leukotriene antagonists].

Allergie et immunologie, 1999
Today, medicinal treatment of asthma over the long term is well codified and involves inhaled corticosteroid therapy, in association or not with beta 2-mimetic substances. Numerous studies have demonstrated the importance of leukotrienes in bronchoconstriction and in the delayed inflammatory reaction of asthma.
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[Leukotriene receptor antagonists].

Bioorganicheskaia khimiia, 1993
The review covers the aspects of classification, specificity and structure--biological activity relations in leukotriene receptor antagonists which blockade the action of the acyclic arachidonate metabolites. Prospects of designing new medicines based on these compounds are also discussed.
D M, Kochev, R S, Vorisova, D A, Zabolotskiĭ, G I, Miagkova   +3 more
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