Results 181 to 190 of about 29,166 (227)
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1995
Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
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Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
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Leukotriene B4 produces hyperalgesia in humans
Prostaglandins, 1985During inflammation, pain receptors are sensitized by inflammatory mediators causing hyperalgesia. Leukotriene B4 (LTB4) is a potent chemoattractant for polymorphonuclear leukocytes in humans in vivo. In the present study we have demonstrated a reduction of the pain threshold in humans after intracutaneous deposition of LTB4.
H, Bisgaard, J K, Kristensen
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Leukotriene B4: Metabolism and Signal Transduction
Archives of Biochemistry and Biophysics, 2001Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Enzymes involved in the biosynthesis and metabolism of LTB4 have been cloned, and their properties are well understood. Two G-protein-coupled receptors (BLT1 and BLT2) have been cloned and characterized.
T, Yokomizo, T, Izumi, T, Shimizu
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Leukotriene B4 biosynthesis by alveolar macrophages
Biochemical and Biophysical Research Communications, 1982Abstract Resting alveolar macrophages in culture synthesized small amount of leukotriene B4. This synthesis was increased 2.5 fold following phagocytic stimulation by zymosan, and was increased 12.6 fold after stimulation with calcium and calcium ionophore A23187. The leukotriene B4 synthesis could be completely inhibited by nordihydroguaiaretic acid
W, Hsueh, F F, Sun
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Biological activities of leukotriene B4
Agents and Actions, 1981Leukotriene B4 isomer III is released from polymorphonuclear leucocytes, monocytes, eosinophils and macrophages in vitro and has been detected and measured in human synovial fluid in vivo. Its most prominent biological activities are to induce the aggregation of and to stimulate the movement (chemokinesis and chemotaxis) of leucocytes in vitro and it ...
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Leukotriene B4 in the immune system
International Journal of Immunopharmacology, 1992Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to lack the enzymes involved in LTB4 formation.
H E, Claesson +2 more
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Leukotriene B4 binding to human neutrophils
Prostaglandins, 1984[3H] Leukotriene B4 (LTB4) binds concentration dependently to intact human polymorphonuclear leukocytes (PMN's). The binding is saturable, reaches equilibrium in 10 min at 4 degrees C, and is readily reversible. Mathematical modeling analysis reveals biphasic binding of [3H] LTB4 indicating two discrete populations of binding sites.
A H, Lin, P L, Ruppel, R R, Gorman
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Leukotriene B4 induces human suppressor lymphocytes
Biochemical and Biophysical Research Communications, 1982Leukotrienes C 4 , D 4 and E 4 are the main bioactive components of slow-reacting substance of anaphylaxis, while leukotriene B 4 has proven to be a potent chemoattractant for neutrophils. We report that LTB 4 is also a potent inducer of suppressor cell activity at concentrations as low as 1 × 10 −14 M.
M, Rola-Pleszczynski +2 more
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Life Sciences, 1990
Due to its potent chemotactic properties leukotriene B4 is an important mediator of inflammatory reactions. Cultured human kidney mesangial cells converted exogenously added leukotriene B4 efficiently into three different more lipophilic metabolites, two of them probably representing dihydro-leukotriene B4 isomers.
V. Kaever +10 more
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Due to its potent chemotactic properties leukotriene B4 is an important mediator of inflammatory reactions. Cultured human kidney mesangial cells converted exogenously added leukotriene B4 efficiently into three different more lipophilic metabolites, two of them probably representing dihydro-leukotriene B4 isomers.
V. Kaever +10 more
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Enzymatic conversion of leukotriene B4 to 6-trans-leukotriene B4 by rat kidney homogenates
Biochemical and Biophysical Research Communications, 1987A novel isomerase reaction leading to conversion of leukotriene B4 to its 6-trans isomer was detected in rat kidney homogenates. The structure of the metabolite was determined by high performance liquid chromatography, ultraviolet spectrometry and gas-liquid chromatography-mass spectrometry.
O, Breuer, S, Hammarström
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