Results 191 to 200 of about 29,391 (230)

Leukotriene B4 produces hyperalgesia in humans

Prostaglandins, 1985
During inflammation, pain receptors are sensitized by inflammatory mediators causing hyperalgesia. Leukotriene B4 (LTB4) is a potent chemoattractant for polymorphonuclear leukocytes in humans in vivo. In the present study we have demonstrated a reduction of the pain threshold in humans after intracutaneous deposition of LTB4.
H, Bisgaard, J K, Kristensen
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Leukotriene B4 Receptors

2015
Leukotriene B4 (LTB4) is a classical pro-inflammatory lipid mediator that activates and recruits neutrophils into inflammatory areas. LTB4 is an arachidonic acid-derived metabolite produced by 5-lipoxygenase and LTA4 hydrolase. To date, two leukotriene B4 receptors, the high-affinity receptor BLT1 and the low-affinity receptor BLT2, have been cloned ...
Tomoaki Koga, Takehiko Yokomizo
openaire   +1 more source

Leukotriene B4: Metabolism and Signal Transduction

Archives of Biochemistry and Biophysics, 2001
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Enzymes involved in the biosynthesis and metabolism of LTB4 have been cloned, and their properties are well understood. Two G-protein-coupled receptors (BLT1 and BLT2) have been cloned and characterized.
T, Yokomizo, T, Izumi, T, Shimizu
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LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT

The Lancet, 1982
Leukotriene B4 (LTB4), a metabolite of arachidonic acid and a potent cytotaxin, is generated by human peripheral polymorphonuclear leucocytes (PMNs) exposed to monosodium urate crystals (MSU). The leukotriene is present in gouty effusions in concentrations significantly greater than those found in synovial fluid from patients with active rheumatoid ...
S A, Rae, E M, Davidson, M J, Smith
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Involvement of leukotriene B4 in arthritis models

Life Sciences, 1998
We investigated the role of leukotriene B4 (LTB4) in murine arthritis models using a leukotriene A4 (LTA4) hydrolase inhibitor, SA6541. SA6541 inhibited the severity of collagen-induced arthritis and muramyl dipeptide (MDP)-induced hyperproliferation of synovial cells in vivo.
F, Tsuji, K, Oki, K, Fujisawa, A, Okahara, M, Horiuchi, S, Mita   +5 more
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Characterization of leukotriene A4 and B4 bioysnthesis

Prostaglandins, 1983
We have studied LTA4 and LTB4 synthesis in a cell-free system from RBL-1 cells. All the enzymes leading to the formation of LTB4 from arachidonic acid are localized in the soluble fraction (100,000 x g supernatant) of these cells. The formation of LTA4 and LTB4 is complete by 10 min.
B A, Jakschik, C G, Kuo
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Leukotriene-B4 Receptor and Signal Transduction

2000
When cells are stimulated with various agonists, cells release arachidonic acid by the action of phospholipases, and arachidonic acid is further converted to various types of leukotrienes (LTs; Samuelsson et al. 1987; Shimizu and Wolfe 1990; Serhan et al. 1996).
T, Shimizu, T, Yokomizo, T, Izumi
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PSORIASIS AND LEUKOTRIENE B4

The Lancet, 1982
S D, Brain, R D, Camp, P M, Dowd, A K, Black, P M, Woollard, A I, Mallet, M W, Greaves   +6 more
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Regulation of the production (leukotriene A4 hydrolase) and the action (leukotriene B4 receptor sites) of leukotriene B4

1987
Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism derived through the action of the 5-lipoxygenase pathway. The end product of the 5-lipoxygenase reaction, LTA4, is converted by a specific enzyme, leukotriene A4 hydrolase, to LTB4 (5[S],12[R]-dihydroxy 6,14-cis-8,10-trans eicosatetraenoic acid).
openaire   +1 more source

Leukotriene B4

General Pharmacology: The Vascular System, 1981
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