Results 181 to 190 of about 18,529 (226)
Some of the next articles are maybe not open access.
Biological activities of leukotriene B4
Agents and Actions, 1981Leukotriene B4 isomer III is released from polymorphonuclear leucocytes, monocytes, eosinophils and macrophages in vitro and has been detected and measured in human synovial fluid in vivo. Its most prominent biological activities are to induce the aggregation of and to stimulate the movement (chemokinesis and chemotaxis) of leucocytes in vitro and it ...
openaire +2 more sources
Enzymatic conversion of leukotriene B4 to 6-trans-leukotriene B4 by rat kidney homogenates
Biochemical and Biophysical Research Communications, 1987A novel isomerase reaction leading to conversion of leukotriene B4 to its 6-trans isomer was detected in rat kidney homogenates. The structure of the metabolite was determined by high performance liquid chromatography, ultraviolet spectrometry and gas-liquid chromatography-mass spectrometry.
O, Breuer, S, Hammarström
openaire +2 more sources
1995
Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
openaire +1 more source
Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
openaire +1 more source
Leukotriene B4: An inflammatory mediator In vivo
Prostaglandins, 1981Leukotriene B4 (LTB4 isomer III), which promotes the movement and aggregation of leucocytes in vitro also stimulates the chemo-attraction of leucocytes and their adherence to vascular endothelium in vivo. These effects were observed directly in the hamster cheek pouch preparation and on histological examination of sections from the rabbit mesentery ...
M A, Bray +2 more
openaire +2 more sources
2015
Leukotriene B4 (LTB4) is a classical pro-inflammatory lipid mediator that activates and recruits neutrophils into inflammatory areas. LTB4 is an arachidonic acid-derived metabolite produced by 5-lipoxygenase and LTA4 hydrolase. To date, two leukotriene B4 receptors, the high-affinity receptor BLT1 and the low-affinity receptor BLT2, have been cloned ...
Tomoaki Koga, Takehiko Yokomizo
openaire +1 more source
Leukotriene B4 (LTB4) is a classical pro-inflammatory lipid mediator that activates and recruits neutrophils into inflammatory areas. LTB4 is an arachidonic acid-derived metabolite produced by 5-lipoxygenase and LTA4 hydrolase. To date, two leukotriene B4 receptors, the high-affinity receptor BLT1 and the low-affinity receptor BLT2, have been cloned ...
Tomoaki Koga, Takehiko Yokomizo
openaire +1 more source
Leukotriene B4 binding to human neutrophils
Prostaglandins, 1984[3H] Leukotriene B4 (LTB4) binds concentration dependently to intact human polymorphonuclear leukocytes (PMN's). The binding is saturable, reaches equilibrium in 10 min at 4 degrees C, and is readily reversible. Mathematical modeling analysis reveals biphasic binding of [3H] LTB4 indicating two discrete populations of binding sites.
A H, Lin, P L, Ruppel, R R, Gorman
openaire +2 more sources
Leukotriene B4 produces hyperalgesia in humans
Prostaglandins, 1985During inflammation, pain receptors are sensitized by inflammatory mediators causing hyperalgesia. Leukotriene B4 (LTB4) is a potent chemoattractant for polymorphonuclear leukocytes in humans in vivo. In the present study we have demonstrated a reduction of the pain threshold in humans after intracutaneous deposition of LTB4.
H, Bisgaard, J K, Kristensen
openaire +2 more sources
Leukotriene B4: Metabolism and Signal Transduction
Archives of Biochemistry and Biophysics, 2001Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Enzymes involved in the biosynthesis and metabolism of LTB4 have been cloned, and their properties are well understood. Two G-protein-coupled receptors (BLT1 and BLT2) have been cloned and characterized.
T, Yokomizo, T, Izumi, T, Shimizu
openaire +2 more sources
LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT
The Lancet, 1982Leukotriene B4 (LTB4), a metabolite of arachidonic acid and a potent cytotaxin, is generated by human peripheral polymorphonuclear leucocytes (PMNs) exposed to monosodium urate crystals (MSU). The leukotriene is present in gouty effusions in concentrations significantly greater than those found in synovial fluid from patients with active rheumatoid ...
S A, Rae, E M, Davidson, M J, Smith
openaire +2 more sources
Involvement of leukotriene B4 in arthritis models
Life Sciences, 1998We investigated the role of leukotriene B4 (LTB4) in murine arthritis models using a leukotriene A4 (LTA4) hydrolase inhibitor, SA6541. SA6541 inhibited the severity of collagen-induced arthritis and muramyl dipeptide (MDP)-induced hyperproliferation of synovial cells in vivo.
F, Tsuji +5 more
openaire +2 more sources