Results 181 to 190 of about 29,391 (230)
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Preparation of the leukotriene B4 analog; 13,13-difluoro-leukotriene B4
Tetrahedron Letters, 1988Abstract The procedure for the synthesis of 13,13-difluoro-leukotriene B 4 [(5S,12S)-5,12-Dihydroxy-6,14-cis-8,10-trans-Eicosatetraenoic Acid] is discribed.
Yuji Hanzawa +3 more
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Prostaglandins, 1986
Specific high-affinity binding sites for [3H]-leukotriene B4 have been identified on membrane preparations from rat and human leukocytes. The rat and human leukocyte membrane preparations show linearity of binding with increasing protein concentration, saturable binding and rapid dissociation of binding by excess unlabelled leukotriene B4. Dissociation
S, Charleson +7 more
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Specific high-affinity binding sites for [3H]-leukotriene B4 have been identified on membrane preparations from rat and human leukocytes. The rat and human leukocyte membrane preparations show linearity of binding with increasing protein concentration, saturable binding and rapid dissociation of binding by excess unlabelled leukotriene B4. Dissociation
S, Charleson +7 more
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Human monocytes convert leukotriene B4 to two dihydro-leukotriene B4-metabolites
Prostaglandins, Leukotrienes and Essential Fatty Acids, 1989Human monocytes metabolize LTB4 by an additional pathway different from omega-oxidation. Reverse-phase high performance liquid chromatography showed four metabolites: 20-COOH-LTB4, 20-OH-LTB4 and two metabolites less polar than LTB4 with an UV maximum at 232 nm.
J, Fauler +3 more
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Assay for the leukotriene B4 receptor
1987Publisher Summary This chapter discusses the binding assay in intact cells, membranes, and a detergent-solubilized preparation and a facile neutrophil aggregation assay that can be used to correlate binding data with biological information. The leukotrienes are metabolites of arachidonic acid whose potent biological activities suggest an important ...
R R, Gorman, A H, Lin
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Inhibition of leukotriene B4 in neutrophils by lipoxins A4 and B4
Agents and Actions, 1991Lipoxins are derived from the oxygenation products of arachidonic acid in human leukocytes. They have exhibited selective biological effects different from those of other eicosanoids. We have examined the effect of lipoxin A4 and B4 (LXA4, LXB4) on the production of leukotriene B4 (LTB4) in human neutrophils. Cultured human polymorphonuclear leukocytes
P, Conti +4 more
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Biological activities of leukotriene B4
Agents and Actions, 1981Leukotriene B4 isomer III is released from polymorphonuclear leucocytes, monocytes, eosinophils and macrophages in vitro and has been detected and measured in human synovial fluid in vivo. Its most prominent biological activities are to induce the aggregation of and to stimulate the movement (chemokinesis and chemotaxis) of leucocytes in vitro and it ...
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1995
Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
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Leukotriene B4 is a powerful chemotactic agent which induces the migration, aggregation and adhesion of leukocytes. It is the major 5-lipoxygenase product of neutrophils formed by hydrolysis of leukotriene A4.
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Enzymatic conversion of leukotriene B4 to 6-trans-leukotriene B4 by rat kidney homogenates
Biochemical and Biophysical Research Communications, 1987A novel isomerase reaction leading to conversion of leukotriene B4 to its 6-trans isomer was detected in rat kidney homogenates. The structure of the metabolite was determined by high performance liquid chromatography, ultraviolet spectrometry and gas-liquid chromatography-mass spectrometry.
O, Breuer, S, Hammarström
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Leukotriene B4: An inflammatory mediator In vivo
Prostaglandins, 1981Leukotriene B4 (LTB4 isomer III), which promotes the movement and aggregation of leucocytes in vitro also stimulates the chemo-attraction of leucocytes and their adherence to vascular endothelium in vivo. These effects were observed directly in the hamster cheek pouch preparation and on histological examination of sections from the rabbit mesentery ...
M A, Bray +2 more
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Leukotriene B4 binding to human neutrophils
Prostaglandins, 1984[3H] Leukotriene B4 (LTB4) binds concentration dependently to intact human polymorphonuclear leukocytes (PMN's). The binding is saturable, reaches equilibrium in 10 min at 4 degrees C, and is readily reversible. Mathematical modeling analysis reveals biphasic binding of [3H] LTB4 indicating two discrete populations of binding sites.
A H, Lin, P L, Ruppel, R R, Gorman
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