Results 171 to 180 of about 18,529 (226)

Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide

Biochemical and Biophysical Research Communications, 1982
Abstract Leukotriene B4 (LTB4) is a potent mediator of pro-inflammatory responses including neutrophil degranulation. Leukotriene B4 dimethylamide has been synthesized and shown to inhibit neutrophil degranulation induced by LTB4. The inhibition required time to develop (∼60 secs), and had a KD of circa 2 × 10−7M, and occurred at concentrations where
H J, Showell, I G, Otterness, A, Marfat, E J, Corey   +3 more
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Leukotriene B4 and Kawasaki Disease

Pediatrics International, 1991
The role of LTB4 in Kawasaki disease as a chemo‐attractant and immunomodulator is reviewed through our own experience and reports by other invenstigators. In our experiment using 19 patients, we measured calcium ionophore‐stimulated LTB4 synthesis in PMNs obtained in three different stages of the illness (acute, convalescent and recovered phases). LTB4
Y, Hamasaki, S, Miyazaki
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Leukotriene B4 and inflammatory disease

Agents and Actions, 1988
Polymorphonuclear leukocytes (PMNL) are prominent at sites of acute inflammation. Their infiltration is stimulated under pathological conditions by a variety of agents which include bacteria, immune complexes and complement derived chemotactic peptides.
R M, McMillan, S J, Foster
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Leukotriene B4 in the immune system

International Journal of Immunopharmacology, 1992
Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to lack the enzymes involved in LTB4 formation.
H E, Claesson, B, Odlander, P J, Jakobsson   +2 more
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Leukotriene B4 and oral cancer

British Journal of Oral and Maxillofacial Surgery, 1990
The quantitation of leukotriene B4 (LTB4) in induced squamous cell carcinoma (SCC) of the Syrian hamster cheek pouch and histologically proven human oral SCC was investigated by a combination of reverse phase-high performance liquid chromatography (RP-HPLC) and radioimmunoassay (RIA). Healthy tissue obtained from these same patients and animals treated
I E, el-Hakim, J D, Langdon, J T, Zakrzewski, J F, Costello   +3 more
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Preparation of the leukotriene B4 analog; 13,13-difluoro-leukotriene B4

Tetrahedron Letters, 1988
Abstract The procedure for the synthesis of 13,13-difluoro-leukotriene B 4 [(5S,12S)-5,12-Dihydroxy-6,14-cis-8,10-trans-Eicosatetraenoic Acid] is discribed.
Yuji Hanzawa, Kei-ichi Kawagoe, Kazuhiko Inazawa, Yoshiro Kobayashi   +3 more
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Leukotriene B3, leukotriene B4 and leukotriene B5; Binding to leukotriene B4 receptors on rat and human leukocyte membranes

Prostaglandins, 1986
Specific high-affinity binding sites for [3H]-leukotriene B4 have been identified on membrane preparations from rat and human leukocytes. The rat and human leukocyte membrane preparations show linearity of binding with increasing protein concentration, saturable binding and rapid dissociation of binding by excess unlabelled leukotriene B4. Dissociation
S, Charleson, J F, Evans, R J, Zamboni, Y, Leblanc, B J, Fitzsimmons, C, Leveillé, P, Dupuis, A W, Ford-Hutchinson   +7 more
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Human monocytes convert leukotriene B4 to two dihydro-leukotriene B4-metabolites

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1989
Human monocytes metabolize LTB4 by an additional pathway different from omega-oxidation. Reverse-phase high performance liquid chromatography showed four metabolites: 20-COOH-LTB4, 20-OH-LTB4 and two metabolites less polar than LTB4 with an UV maximum at 232 nm.
J, Fauler, K H, Marx, V, Kaever, J C, Frölich   +3 more
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Assay for the leukotriene B4 receptor

1987
Publisher Summary This chapter discusses the binding assay in intact cells, membranes, and a detergent-solubilized preparation and a facile neutrophil aggregation assay that can be used to correlate binding data with biological information. The leukotrienes are metabolites of arachidonic acid whose potent biological activities suggest an important ...
R R, Gorman, A H, Lin
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Inhibition of leukotriene B4 in neutrophils by lipoxins A4 and B4

Agents and Actions, 1991
Lipoxins are derived from the oxygenation products of arachidonic acid in human leukocytes. They have exhibited selective biological effects different from those of other eicosanoids. We have examined the effect of lipoxin A4 and B4 (LXA4, LXB4) on the production of leukotriene B4 (LTB4) in human neutrophils. Cultured human polymorphonuclear leukocytes
P, Conti, M, Reale, R C, Barbacane, M R, Panara, M, Bongrazio   +4 more
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