Results 171 to 180 of about 29,391 (230)
Some of the next articles are maybe not open access.
Biosynthesis of leukotriene B4
Seminars in Immunology, 2017Leukotriene B4 (LTB4) is a lipid mediator derived from arachidonic acid (AA) by the sequential action of 5-lipoxygenase (5-LOX), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4H). It was initially recognized for its involvement in the recruitment of neutrophils and is one of the most potent chemotactic agents known to date.
Min, Wan +3 more
openaire +2 more sources
A radioimmunoassay for leukotriene B4
Prostaglandins, 1982A radioimmunoassay for leukotriene B4 has been developed. The assay is sensitive; 5 pg LTB4 caused significant inhibition of binding of [3H]-LTB4 and 50% displacement occurred with 30 pg. The specificity of the assay has been critically examined; prostaglandins, thromboxane B2 and arachidonic acid do not exhibit detectable cross-reactions (less than 0 ...
J A, Salmon, P M, Simmons, R M, Palmer
openaire +2 more sources
Leukotriene B4 in Hemodialysis
Artificial Organs, 1990Abstract: Leukotrienes are eicosanoids arising from arachidonic acid via 5 lipooxygenase, an enzyme essentially present in leukocyte cells. Leukotriene B4 might be an indicator of neutropolymorphonuclear leukocyte activation when there is contact with artificial membranes.
A, Tridon +6 more
openaire +2 more sources
Prostaglandins & Other Lipid Mediators, 2002
Leukotriene B4 (LTB4) is a potent chemotactic agent and activating factor for granulocytes. Two cell surface receptors for LTB4 (BLT1 and BLT2) have been isolated in the last few years. These receptors are G-protein-coupled receptors (GPCR), and they have 45% amino acid identity. BLT1 and BLT2 are high- and low- affinity receptors, respectively.
Akiko, Toda +2 more
openaire +2 more sources
Leukotriene B4 (LTB4) is a potent chemotactic agent and activating factor for granulocytes. Two cell surface receptors for LTB4 (BLT1 and BLT2) have been isolated in the last few years. These receptors are G-protein-coupled receptors (GPCR), and they have 45% amino acid identity. BLT1 and BLT2 are high- and low- affinity receptors, respectively.
Akiko, Toda +2 more
openaire +2 more sources
Prostaglandins, 1983
Leukotriene B4 (LTB4) (I) has been converted to its N-(3-amino-propyl)amide derivative (III) and to its hydrazide derivative (VII) via LTB4 delta-lactone. The amide (III) was coupled with Bovine Serum Albumin using 1,5-difluoro-2,4-dinitrobenzene as coupling agent.
R N, Young, R, Zamboni, J, Rokach
openaire +2 more sources
Leukotriene B4 (LTB4) (I) has been converted to its N-(3-amino-propyl)amide derivative (III) and to its hydrazide derivative (VII) via LTB4 delta-lactone. The amide (III) was coupled with Bovine Serum Albumin using 1,5-difluoro-2,4-dinitrobenzene as coupling agent.
R N, Young, R, Zamboni, J, Rokach
openaire +2 more sources
Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide
Biochemical and Biophysical Research Communications, 1982Abstract Leukotriene B4 (LTB4) is a potent mediator of pro-inflammatory responses including neutrophil degranulation. Leukotriene B4 dimethylamide has been synthesized and shown to inhibit neutrophil degranulation induced by LTB4. The inhibition required time to develop (∼60 secs), and had a KD of circa 2 × 10−7M, and occurred at concentrations where
H J, Showell +3 more
openaire +2 more sources
Leukotriene B4 and Kawasaki Disease
Pediatrics International, 1991The role of LTB4 in Kawasaki disease as a chemo‐attractant and immunomodulator is reviewed through our own experience and reports by other invenstigators. In our experiment using 19 patients, we measured calcium ionophore‐stimulated LTB4 synthesis in PMNs obtained in three different stages of the illness (acute, convalescent and recovered phases). LTB4
Y, Hamasaki, S, Miyazaki
openaire +2 more sources
Leukotriene B4 and inflammatory disease
Agents and Actions, 1988Polymorphonuclear leukocytes (PMNL) are prominent at sites of acute inflammation. Their infiltration is stimulated under pathological conditions by a variety of agents which include bacteria, immune complexes and complement derived chemotactic peptides.
R M, McMillan, S J, Foster
openaire +2 more sources
Leukotriene B4 in the immune system
International Journal of Immunopharmacology, 1992Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to lack the enzymes involved in LTB4 formation.
H E, Claesson +2 more
openaire +2 more sources
Leukotriene B4 and oral cancer
British Journal of Oral and Maxillofacial Surgery, 1990The quantitation of leukotriene B4 (LTB4) in induced squamous cell carcinoma (SCC) of the Syrian hamster cheek pouch and histologically proven human oral SCC was investigated by a combination of reverse phase-high performance liquid chromatography (RP-HPLC) and radioimmunoassay (RIA). Healthy tissue obtained from these same patients and animals treated
I E, el-Hakim +3 more
openaire +2 more sources