Results 181 to 190 of about 12,649 (233)
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Pharmacology of Leukotriene Receptor Antagonists
American Journal of Respiratory and Critical Care Medicine, 1998Abstract Preclinical pharmacological studies have demonstrated that cysLT1 receptor antagonists, such as zafirlukast, montelukast, and pobilukast, are potent and selective antagonists of cysteinyl leukotriene (cysLT) activity. In vitro, these agents compete with [3H]LTD4 for binding to cysLT1 receptors present on guinea pig and human ...
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Leukotriene receptor antagonists - an update
Drug and Therapeutics Bulletin, 2005Montelukast (Singulair - MSD) and zafirlukast (Accolate - AstraZeneca) are oral leukotriene receptor antagonists, licensed for the treatment of patients with asthma. In 1998, soon after their launch, we concluded that there was insufficient evidence to clearly define their place in treatment.1 Here, we reconsider their role in adults and children with ...
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Leukotriene receptor antagonists in asthma therapy
Journal of Allergy and Clinical Immunology, 2003In persons with asthma, the cysteinyl leukotrienes possess multiple inflammatory properties in vitro and have long been considered to be a potentially important mediator of asthma and an attractive target for therapeutic intervention. Controlled clinical trials have documented the efficacy of leukotriene receptor antagonists in asthma treatment, but ...
Peters, Stephen P. +10 more
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Safety of leukotriene receptor antagonists in pregnancy
Journal of Allergy and Clinical Immunology, 2007Asthma is a chronic disorder that affects about 8% of pregnant women and may complicate pregnancy. Adequate asthma therapy in pregnancy is crucial but challenging because of safety concerns for the fetus.To evaluate the safety of gestational asthma therapy with leukotriene receptor antagonists (LTRAs) for the mother and fetus/newborn.Subjects were ...
Ludmila N, Bakhireva +6 more
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Leukotriene receptor antagonists for exacerbations of asthma
Paediatric Respiratory Reviews, 2012Emergency department visits and hospital admissions for acute asthma represent a considerable burden on health services worldwide. Many patients presenting with acute asthma do not respond fully to standard therapy of beta2agonists, corticosteroids and oxygen so additional therapies are required.
Emma, Welsh +3 more
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Leukotriene receptor antagonists in chronic urticaria
Allergy, 2001. SOME patients with chronic idiopathic urticaria (CIU) do not respond to antihistamines and require long-term steroid administration or even cyclosporin to control their disease. Recently, several studies reported good results with antileukotriene drugs in CIU (1–4); however, a prospective investigation aiming to detect which patients are more likely ...
R, Asero, A, Tedeschi, M, Lorini
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Leukotriene Receptor Antagonists and Antiallergy Drugs
2016As one of the candidates of the therapeutic strategy for asthma in addition to inhaled corticosteroids (ICS), leukotriene receptor antagonists (LTRAs) are known to be useful for long-term management of asthma patients complicated by allergic rhinitis (AR) or exercise-induced asthma (EIA).
Tsutomu, Tamada, Masakazu, Ichinose
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Leukotriene Receptor Antagonists in the Treatment of Asthma
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2001The role of leukotriene receptor antagonists in the treatment of persistent asthma is in evolution. Pivotal 8–12‐week, randomized, controlled trials in both adults and children have shown efficacy, as defined by standard asthma outcomes. Tolerance to therapy did not develop, nor did rebound worsening of asthma symptoms once therapy was withdrawn.
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Effects of cysteinyl leukotrienes and leukotriene receptor antagonists on markers of inflammation
Journal of Allergy and Clinical Immunology, 2003The understanding that asthma pathophysiology includes an inflammatory component has spurred the more aggressive use of anti-inflammatory therapies and created a need for effective tools to measure inflammation. Biomarkers of airway inflammation proposed are obtained by methods that are direct but highly invasive (bronchial biopsy, bronchoalveolar ...
Sampson, Anthony P. +2 more
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[Leukotriene receptor antagonists].
Bioorganicheskaia khimiia, 1993The review covers the aspects of classification, specificity and structure--biological activity relations in leukotriene receptor antagonists which blockade the action of the acyclic arachidonate metabolites. Prospects of designing new medicines based on these compounds are also discussed.
D M, Kochev +3 more
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