Results 91 to 100 of about 1,159,991 (294)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Analysis of Failures of Automatic Level Crossing Devices

Engineering Proceedings
The safety of automatic level crossing devices (ALDs) is of utmost importance due to the need to ensure safe passage through railway crossings—accidents must not be allowed.
Emiliya Dimitrova, Vasil Dimitrov, Dragomira Dimitrova   +2 more
doaj   +1 more source

Preventing railway suicides through level crossing removal: a multiple-arm pre-post study design in Victoria, Australia. [PDF]

Soc Psychiatry Psychiatr Epidemiol, 2022
Clapperton A, Dwyer J, Spittal MJ, Roberts L, Pirkis J.   +4 more
europepmc   +1 more source

Magnetocaloric effect as a signature of quantum level-crossing for a spin-gapped system

, 2019
Recent research dealing with magnetocaloric effect (MCE) study of antiferromagnetic (AFM) low dimensional spin systems have revealed a number of fascinating ground-state crossover characteristics upon application of external magnetic field.
Chakraborty, Tanmoy, Mitra, Chiranjib
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Modelling of Signal - Level Crossing System

Advances in Electrical and Electronic Engineering, 2006
The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML), version 1.4, which enables specification, visualisation, construction and ...
Daniel Novak
doaj  

Einstein-Yang-Mills Sphalerons and Level Crossing

, 1994
The fermion energy spectrum along paths which connect topologically distinct vacua in the Einstein-Yang-Mills theory passing through the gravitational sphaleron equilibrium solutions is investigated.Comment: LaTeX, 13 pages + uudecoded compressed file ...
Bartnik, Boguta, Brodbeck, Callan, Chandrasekhar, Christ, Cottingham, Dashen, Gal'tsov, Gal'tsov, Gal'tsov, Gibbons, Gibbons, Gibbons, Goldberg, Hellmund, Kiskis, Klinkhamer, Kunz, Kunzle, Landau, Matveev, Mikhail S. Volkov, Newman, Newman, Nolte, Ringwald, Sudarsky, Volkov, Volkov, Witten, Zhou   +31 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Light QCD axion dark matter from double level crossings

Physics Letters B
The even light QCD axion called the ZN axion can both solve the strong CP problem and account for the dark matter (DM). We point out that the single and double level crossings can naturally take place in the mass mixing between the ZN axion and axionlike
Hai-Jun Li, Ying-Quan Peng, Wei Chao, Yu-Feng Zhou   +3 more
doaj   +1 more source

Vibroisolation of railway crossings with the application of shape-memory elements [PDF]

Transport Problems, 2009
This research presents existing problem of railway elements and motor –vehicle road elements at their intersections. The objects of simulation research were vehicles passing over a level crossing of automobile road and rail-transportation road. Objective
Jan TARGOSZ
doaj