Results 111 to 120 of about 1,160,707 (276)

Experimental tests of vehicle body accelerations at selected road and rail crossings

MATEC Web of Conferences, 2019
Vehicles moving across the railway are exposed to the dynamic reaction of unevenness of surface on those level crossing. This significantly influences on the increase of the acceleration as well as forces values transferred to the body of the car.
Waluś Konrad J., Polasik Jakub, Mielniczuk Janusz, Warguła Łukasz   +3 more
doaj   +1 more source

Dynamics of a two-state system through a real level crossing

, 2015
The dynamics of a two-state system whose energies undergo a real crossing at some instant of time is studied. At this instant, both the coupling and the detuning vanish simultaneously, which leads to an exact degeneracy of the eigenenergies of the system.
Militello, Benedetto D., Vitanov, Nikolay V.   +1 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Research on the city tram collision at a level crossing

Advances in Mechanical Engineering, 2018
The collision simulation between a city tram and a car at a level crossing is carried out based on the multi-body dynamics. Compared with the finite element method, this method has an obvious advantage of fast computation speed, so that it is convenient ...
Hechao Zhou, Chao Zhang, Jun Zhan, Jimin Zhang   +3 more
doaj   +1 more source

Einstein-Yang-Mills Sphalerons and Level Crossing

, 1994
The fermion energy spectrum along paths which connect topologically distinct vacua in the Einstein-Yang-Mills theory passing through the gravitational sphaleron equilibrium solutions is investigated.Comment: LaTeX, 13 pages + uudecoded compressed file ...
Bartnik, Boguta, Brodbeck, Callan, Chandrasekhar, Christ, Cottingham, Dashen, Gal'tsov, Gal'tsov, Gal'tsov, Gibbons, Gibbons, Gibbons, Goldberg, Hellmund, Kiskis, Klinkhamer, Kunz, Kunzle, Landau, Matveev, Mikhail S. Volkov, Newman, Newman, Nolte, Ringwald, Sudarsky, Volkov, Volkov, Witten, Zhou   +31 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Adaptive Rate Sampling and Filtering Based on Level Crossing Sampling

EURASIP Journal on Advances in Signal Processing, 2009
The recent sophistications in areas of mobile systems and sensor networks demand more and more processing resources. In order to maintain the system autonomy, energy saving is becoming one of the most difficult industrial challenges, in mobile computing.
Saeed Mian Qaisar, Laurent Fesquet, Marc Renaudin   +2 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source