Results 131 to 140 of about 4,243,261 (296)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Analyzing Diabetes Datasets using Data Mining
, 2017 Data mining techniques explore critical information in various domains (for example in CRM (customer relationship management), HR (Human Resource), GIS (Geographic Information System) etc.) but most importantly in medical domain. In medical domain, data
null Anita Shaikh +5 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The Study of Hematological Parameters of Animals in the Application of Enterosorbent Food Fiber
, 2019 One of the most important issues is the study of healthy nutrition of the population of Kazakhstan. Proper nutrition provides growth, contributes to the prevention of diseases, increase efficiency and prolong life of people, while creating conditions for
Y. Kuandykov +8 more
core +1 more source
Research on improved level set image segmentation method. [PDF]
PLoS One, 2023 Zhang M, Meng D, Liu L, Wen J.
europepmc +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Fast initialization of level set method and an improvement to chan-vese model
, 2004 The initialization is an important step in the level set method. However it is a computational time-consuming step. In order to speed up the level set evolution procedures, we first introduce a new initialization algorithm based on the vector distance ...
Wu XJ(吴晓军) +3 more
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