Results 51 to 60 of about 223,578 (243)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Struktur modal: Faktor penentu dan pengaruhnya pada nilai perusahaan

open access: yesJurnal Siasat Bisnis, 2016
Penelitian ini mempunyai dua tujuan utama yakni, pertama untuk mengetahui dan menganalisis faktor-faktor yang menentukan struktur modal, kedua untuk mengetahui dan menganalisis pengaruh faktor-faktor penentu struktur modal terhadap nilai perusahaan ...
Sutrisno Sutrisno
doaj  

Towards Extending Dividend Puzzle Debate: What Motivates Distribution of Corporate Earnings in Tanzania?

open access: yesInternational Journal of Financial Studies, 2020
This paper investigates the determinants of dividend policy in Tanzania. The study employed a panel data of non-financial firms listed on the Dar es Salaam Stock Exchange (DSE) for the period 2008−2017.
Josephat Lotto
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Corporate Taxation and Capital Structure: Evidence from Russia

open access: yesКорпоративные финансы, 2017
The study aims to empirically analyze whether corporate taxation has an impact on firm capital structure decisions. The results, based on panel data on Russian private (non-listed), non-financial and non-state owned firms, show that taxation has a ...
Evgeny Ilyukhin
doaj   +1 more source

Leverage dan growth opportunity mempengaruhi nilai perusahaan melalui profitabilitas

open access: yesJurnal Ekonomi Modernisasi, 2020
Companys value is a reflectiond or good name of company. The company value means a lot to investors and potential investors. This researcsh aims to examined the effect of leverage and growth opportunityd on corporate value through profitability.
Supami Wahyu Setiyowati   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Fundamental factors influencing returns of shares listed on the Johannesburg Stock Exchange in South Africa

open access: yesJournal of Economic and Financial Sciences, 2016
This study investigated the relationship between share returns and nine variables that had been proven to influence returns in previous research, using a multiple regression analysis.
Marise Vermeulen
doaj   +1 more source

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