Results 91 to 100 of about 3,343,278 (165)

Mucuna pruriens as a Sustainable Functional Food: Applications From Seed to Product

Modern Agriculture, Volume 4, Issue 2, December 2026.
This review highlights Mucuna pruriens as a nutrient‐rich legume with significant nutritional, therapeutic, and agricultural value. Its protein‐rich seeds contain essential minerals and L‐DOPA, but high antinutritional compounds require effective processing before consumption.
Crossby Osei Tutu, Reuben Acheampong, Papa Toah Akonor, Bernard Kwabena Asiedu, Rexford Obeng, Anthonia Helga Andoh‐Odoom, Dora Duah‐Bisiw, Jacob Ulzen, Michael Wiafe‐Kwagyan, Nii Korley Kortei, Justice Owusu‐Bempah   +10 more
wiley   +1 more source

Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia

, 2010
The aim of the present study was to evaluate the role of the nitric oxide/cyclic guanosine monophosphate pathway in corticostriatal long-term depression induction in a model of levodopa-induced dyskinesia in experimental parkinsonism.
Calabresi, Paolo, Carmela Giampà, Francesca R. Fusco, Massimiliano Di Filippo, Giampa', Carmela, Bagetta, Vincenza, Pendolino, Valentina, Paolo Calabresi, Carmelo Sgobio, Vincent Paillè, Picconi, Barbara, Di Filippo, Massimiliano, Sgobio, Carmelo, Alessandro Tozzi, Tozzi, Alessandro, Barbara Picconi, Valentina Pendolino, Paillé, Vincent, Giampà, Carmela, Fusco, Francesca, Ghiglieri, Veronica, Vincenza Bagetta, Veronica Ghiglieri   +22 more
core   +1 more source

μ- and δ-Opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease

, 2001
Long-term treatment of Parkinson's disease with levodopa is complicated by the emergence of involuntary movements, known as levodopa-induced dyskinesia.
Crossman, Alan R., Henry, Brian, Fox, Susan H., Brotchie, Jonathan M.   +3 more
core   +1 more source

Safinamide modulates striatal glutamatergic signaling in a rat model of levodopa-induced dyskinesia

, 2018
Safinamide (Xadago) is a novel dual-mechanism drug that has been approved in the European Union and United States as add-on treatment to levodopa in Parkinson's disease therapy.
Novello S., Morari M., Gardoni F., Melloni E., Padoani G., Sosti V., Brugnoli A., Mellone M., Caccia C., Keywood C., Pisano C. A., Kulisevsky J., Vailati S.   +12 more
core   +2 more sources

Hyperdopaminergic Manifestations in Parkinson’s Disease: Correlation between Impulse Control Disorders and Levodopa- Induced Dyskinesia [PDF]

Ain Shams Medical Journal
Objective: To explore the relationship between levodopa-induced dyskinesia and impulse control disorders (ICDs) inParkinson’s disease (PD), exploring the hyperdopaminergic motor and non-motor state.Methods: A cross-sectional study was conducted on 30 PD ...
ALIA MANSOUR, Ahmed .Ammar, Ahmed Gaber, Shima Ebrahim, Heba Khafaga   +4 more
doaj   +1 more source

Does Late Levodopa Administration Delay the Development of Dyskinesia in Patients with De Novo Parkinson's Disease?

, 2018
BACKGROUND: It remains controversial whether late levodopa administration is a reasonable approach to reducing the risk of levodopa-induced dyskinesia in Parkinson's disease. OBJECTIVE: This study aimed to investigate the effects of levodopa sparing
이필휴, 손영호, 유한수, 정석종, 이혜선   +4 more
core   +1 more source

A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia [PDF]

, 2016
BackgroundThis phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor 7 agonist AQW051 in patients with Parkinson's disease and levodopa-induced dyskinesia.
Jaeger, J, Derkinderen, P, Weiss, Markus, Johns, D, Jaeger, Judith, Weiss, M, Maruff, Paul, Ceballos-Baumann, A, Storch, A, Defebvre, L, Zhang, L., Feuerbach, D, Linazasoro, G, Schwarz, Johannes, Espay, Alberto J., Geny, C, Gomez-Mancilla, B, Hockey, Hans-Ulrich, Linazasoro, Gurutz, Espay, AJ, Berg, Daniela, Gomez-Mancilla, Baltazar, Tranchant, Christine, Azulay, Jean-Philippe, Trenkwalder, C, Corvol, Jean-Christophe, Azulay, JP, Eggert, K, Rascol, O, Gostkowski, Michal, Tranchant, C, Rozenberg, Izabela, Sovago, Judit, Geny, Christian, Ceballos-Baumann, Andres, Feigin, Andrew, Johns, Donald, Storch, Alexander, Stocchi, Fabrizio, Di Paolo, Therese, Gostkowski, M, Broussolle, E, Schwarz, J, Defebvre, Luc, Di Paolo, T, Berg, D, Feigin, A, Stocchi, F, Derkinderen, Pascal, Durif, F, Feuerbach, Dominik, Houeto, JL, Eggert, Karla, Houeto, Jean-Luc, Corvol, JC, Maruff, P, Jakab, Annamaria, Broussolle, Emmanuel, Durif, Franck, Sovago, J, Rozenberg, I, Jakab, A, Rascol, Olivier, Zhang, L, Trenkwalder, Claudia, Hockey, HU   +65 more
core   +1 more source

No New Relevant Treatment Options for L-DOPA-Induced Dyskinesia from a Clinician’s Point of View

Neurology International
Background: The term dyskinesia describes involuntary movements of the face, body and extremities. Frequently, they appear following and in relation with prior oral long-lasting and high-dose levodopa therapy in Parkinson’s disease patients.
Thomas Müller
doaj   +1 more source

Transcriptome‐Based Identification of ZZEF1 and ENTPD5 as Candidate Genes for Dystonia

Movement Disorders, EarlyView.
Alexandra Rudnik, Mirja Thomsen, Vicente A. Yépez, Ai Huey Tan, Frauke Hinrichs, Sebastian Loens, Shen‐Yang Lim, Yi Wen Tay, Thomas Musacchio, Sören Franzenburg, Tobias Bäumer, Marius Möller, Hauke Busch, Christine Klein, Norbert Brüggemann, Katja Lohmann   +15 more
wiley   +1 more source

Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.

, 2010
OBJECTIVE:: Striatal serotonin projections have been implicated in levodopa-induced dyskinesia by providing an unregulated source of dopamine release.
Dovero, Sandra, Rylander, Daniella,, Cenci Nilsson, Angela, Rylander, Daniella, Daniella Rylander, Bezard, Erwan, Sandra Dovero, Andrew J. Lees, Sean S. O'Sullivan, Laurent Descarries, M. Angela Cenci, Martin Parent, Lees, Andrew J, Parent, Martin, Descarries, Laurent, O'Sullivan, Sean S, Lund University., Erwan Bezard, Cenci Nilsson, Angela,   +18 more
core   +1 more source