Results 81 to 90 of about 3,343,278 (165)

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhuri, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source

Ranitidine reduced levodopa-induced dyskinesia by remodeling neurochemical changes in hemiparkinsonian model of rats

, 2015
Hongjuan Shi,1,2,* Xinxin Yang,2,3,* Hui Zhao,4 Shenyang Zhang,2 Jie Zu,2 Wei Zhang,2 Xia Shen,2 Guiyun Cui,2,3 Fang Hua,2,3 Chuanzhu Yan1 1Department of Neurology, Qilu Hospital of Shangdong University, Jinan, 2Department of Neurology, Affiliated ...
Yang X, Zhang W, Hua F, Cui G, Yan C, Zhang S, Shen X, Shi H, Zhao H, Zu J   +9 more
core  

Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism

Movement Disorders, EarlyView.
Abstract Background Bilateral pallidal deep brain stimulation (GPi‐DBS) is effective for dystonia. Long‐term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives To assess 15‐year dystonia outcomes and characterize parkinsonism after bilateral GPi‐DBS.
Clément Desjardins, Cécilia Bonnet, Elena Moro, David Grabli, Valérie Fraix, Marie‐Laure Welter, Laurent Vercueil, Soledad Navarro, Carine Karachi, Thibaud Charrier, Sylvie Raoul, Mathilde Guibourd de Luzinais, Emmanuel Cuny, Stéphan Chabardes, Pierre Burbaud, Dominique Guehl, Pascal Derkinderen, Marie Vidailhet, on behalf of the French SPIDY Study Group, Olivier Detante, Valérie Fraix, Pierre Pollak, Laurent Vercueil, Yves Agid, David Grabli, Jean‐Luc Houeto, Valérie Mesnage, Marie Vidailhet, Marie‐Laure Welter, Pierre Césaro, Luc Defebvre, Alain Destée, Pierre Krystkowiak, Alim‐Louis Benabid, Stephan Chabardes, Adnan Koudsie, Philippe Cornu, Soledad Navarro, Serge Blond, Gustavo Touzet, Abdelhamid Benazzouz, Bernard Pidoux, François Cassim, Sylvie Grand, Jean‐François Le Bas, Didier Dormont, Jean‐Pierre Pruvo, Christine Delmaire, Claire Ardouin, Bernard Pillon, Valérie Hahn‐Barma, Kathy Dujardin.   +51 more
wiley   +1 more source

Randomized clinical trial of topiramate for levodopa-induced dyskinesia in Parkinson\u27s disease

Background: The antiepileptic drug topiramate reduces levodopa-induced dyskinesia without exacerbating parkinsonism in animal models. We report a randomized, double-blind, placebo-controlled crossover trial in patients with Parkinson\u27s disease and ...
Kass-Iliyya L, Kobylecki C, Silverdale MA, Kellett MW, Burn DJ, Crossman AR   +5 more
core   +4 more sources

Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and β-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson's disease

Drug Design, Development and Therapy, 2013
Na Wu,1 Xinxin Yang,1 Lu Song,1 Jianglei Wei,2 Zhenguo Liu1 1Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 2Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's ...
Wu N, Yang X, Song L, Wei J, Liu Z
doaj  

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys

, 2000
OBJECTIVE: To evaluate the contribution of amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA) glutamate receptors to the pathogenesis of parkinsonian signs and levodopa-induced dyskinesias. BACKGROUND: Motor fluctuations and dyskinesias reflect,
Blanchet, P. J., Verhagen, L., Chase, T. N., Lamers, E., Konitsiotis, S.   +4 more
core  

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.

, 2001
The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus
Sieradzan, KA, Dick, JP, Fox, SH, Brotchie, JM, Hill, M, Crossman, AR   +5 more
core   +1 more source

Neuropsychiatric‐Led Presentation of Late‐Onset Parkin‐Related Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Sarah Fullam, Shane Lyons, Martha Finnegan, Richard Walsh, Sean O'Dowd   +4 more
wiley   +1 more source

Surgical Treatment of Dyskinesia in Parkinson’s Disease

Frontiers in Neurology, 2014
One of the main indications for stereotactic surgery in Parkinson’s disease (PD) is the control of levodopa induced dyskinesia. This can be achieved by by pallidotomy and globus pallidus internus (GPi) deep brain stimulation (DBS) or by subthalamotomy ...
Renato Puppi Munhoz, Antonio eCerasa, Michael S. Okun   +2 more
doaj   +1 more source