Results 71 to 80 of about 3,343,278 (165)
npj Parkinson's DiseasePrevious observational studies suggested that sarcopenia is associated with Parkinson disease (PD), but it is unclear whether this association is causal. The objective of this study was to examine causal associations between sarcopenia-related traits and
Tao Wang +5 more
doaj +1 more source
Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe +15 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.
Bruno Antunes Contrucci +10 more
wiley +1 more source
Exercise and Motor Complications in Parkinson's Disease: A Systematic Review and Meta‐Analysis
Movement Disorders Clinical Practice, EarlyView.Abstract Background Levodopa remains the most effective pharmacological treatment for Parkinson's disease (PD), but long‐term use commonly leads to motor complications such as levodopa‐induced dyskinesia (LID) and motor fluctuations, significantly contributing to disability. Exercise is well‐established for improving motor and non‐motor symptoms in PD;
Priscila Nóbrega‐Sousa +5 more
wiley +1 more source
A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders
Movement Disorders, EarlyView.Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta +6 more
wiley +1 more source
Decoding Finely Tuned Gamma Oscillations in Chronic Deep Brain Stimulation for Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Finely tuned Gamma (FTG) activity—spontaneous narrowband Gamma oscillations (sFTG) or entrained to half the stimulation frequency (eFTG)—is typically linked to on‐medication states and dyskinesia in Parkinson's disease (PD), making it a potential physiomarker for adaptive deep brain stimulation (aDBS).
Marjolein Muller +8 more
wiley +1 more source
Is Extended-Release Amantadine Effective at Treating Levodopa- Induced Dyskinesia in Parkinson’s Disease Patients? [PDF]
, 2022 Objective: The objective of this selective EBM review is to determine Is extended-release amantadine efficacious in treating levodopa-induced dyskinesia in Parkinson\u27s disease patients?” Study Design: A systematic review of three randomized ...
Mendoza, Maegan M
core +1 more source
Rapid drug increase and early onset of levodopa-induced dyskinesia in Parkinson's disease.
PLoS ONE, 2020 A higher levodopa dose is a strong risk factor for levodopa-induced dyskinesia (LID) in patients with Parkinson's disease (PD). However, levodopa dose can change during long-term medication.
Jin Yong Hong +6 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard +33 more
wiley +1 more source
Why Use Immersive Virtual Reality to Assess Gait in Functional Motor Disorders?
Movement Disorders, EarlyView.Abstract Background Functional motor disorders (FMD) are disabling conditions modulated by attentional demands. Immersive virtual reality (iVR) engages multiple attentional and sensory networks, but its application in people with FMD (PwFMD) remains limited.
Marialuisa Gandolfi +14 more
wiley +1 more source