Levodopa versus non-levodopa brain language fMRI in Parkinson’s disease [PDF]
Objective: To identify the effect of levodopa in language areas inParkinson’s disease patients. Methods: We evaluated 50 patientswith mild to moderate Parkinson’s disease, age and gender pairedto 47 healthy volunteers.
Paula Ricci Arantes +7 more
doaj +3 more sources
The role of gut microbiota tyrosine decarboxylases in levodopa pharmacokinetics: insights from a levodopa challenge test. [PDF]
Background The gut microbiota is known to influence levodopa metabolism in the intestinal tract, primarily through the action of tyrosine decarboxylase, an enzyme encoded by the tyrosine decarboxylase gene (tyrDC). However, the effect of the abundance of
Feng Y +5 more
europepmc +2 more sources
Levodopa-Induced Changes in Electromyographic Patterns in Patients with Advanced Parkinson’s Disease [PDF]
Levodopa medication is the most efficient treatment for motor symptoms of Parkinson’s disease (PD). Levodopa significantly alleviates rigidity, rest tremor, and bradykinesia in PD.
Verneri Ruonala +5 more
doaj +4 more sources
Introduction: Post-synaptic dopamine receptor supersensitivity (DARSS) has been extensively researched by Dr. Masaya Segawa, who has investigated the efficacy of very-low-dose levodopa therapy (VLDT; 0.5–1 mg/kg/day).
Kyoko Hoshino +15 more
doaj +1 more source
Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals
To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed.
S. Jost +27 more
semanticscholar +1 more source
Gastrointestinal barriers to levodopa transport and absorption in Parkinson's disease
Levodopa is the gold standard for the symptomatic treatment of Parkinson's disease (PD). There are well documented motor and non‐motor fluctuations, however, that occur almost inevitably once levodopa is started after a variable period in people with PD.
V. Leta +13 more
semanticscholar +1 more source
BackgroundWhile treatment with levodopa remains the cornerstone of Parkinson's disease (PD) management, chronic oral therapy is often associated with the development of motor complications, that correlate to fluctuating levodopa plasma concentrations ...
Peter A. LeWitt +7 more
doaj +1 more source
Levodopa-Induced Dyskinesia in Parkinson’s Disease: Pathogenesis and Emerging Treatment Strategies
The most commonly used treatment for Parkinson’s disease (PD) is levodopa, prescribed in conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement therapy using levodopa during the course of the disease’s progression ...
Destany K. Kwon +3 more
semanticscholar +1 more source
Levodopa and the dopamine receptor D1-Hippo/yes-associated protein axis: A novel therapeutic avenue for liver fibrosis. [PDF]
Xie SS, Liu ZG.
europepmc +2 more sources
Levodopa responsive gait dynamics in OFF- and ONOFF-state freezing of gait in Parkinson’s disease
Background: In people with Parkinson’s disease (PwPD), Freezing of Gait (FOG) episodes can be levodopa responsive (OFF-FOG) or levodopa unresponsive (ONOFF-FOG).
Tuhin Virmani +3 more
doaj +1 more source

