Results 11 to 20 of about 60,411 (353)
Therapeutic Advances in Chronic Disease, 2019 Background: Inhaled levodopa may quickly resolve off periods in Parkinson’s disease. Our aim was to determine the pharmacokinetics and tolerability of a new levodopa dry-powder inhaler.
Marianne Luinstra +9 more
doaj +2 more sources
Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals
Movement Disorders, 2023 To compare drug regimens across clinical trials in Parkinson's disease (PD) conversion formulae between antiparkinsonian drugs have been developed.
S. Jost +27 more
semanticscholar +1 more source
Gastrointestinal barriers to levodopa transport and absorption in Parkinson's disease
European Journal of Neurology, 2023 Levodopa is the gold standard for the symptomatic treatment of Parkinson's disease (PD). There are well documented motor and non‐motor fluctuations, however, that occur almost inevitably once levodopa is started after a variable period in people with PD.
V. Leta +13 more
semanticscholar +1 more source
Levodopa-Induced Dyskinesia in Parkinson’s Disease: Pathogenesis and Emerging Treatment Strategies
Cells, 2022 The most commonly used treatment for Parkinson’s disease (PD) is levodopa, prescribed in conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement therapy using levodopa during the course of the disease’s progression ...
Destany K. Kwon +3 more
semanticscholar +1 more source
Mechanisms of peripheral levodopa resistance in Parkinson’s disease
npj Parkinson's Disease, 2022 Parkinson’s disease (PD) is an increasingly common neurodegenerative condition. The disease has a significant negative impact on quality of life, but a personalized management approach can help reduce disability. Pharmacotherapy with levodopa remains the
Milan Beckers, B. Bloem, M. Verbeek
semanticscholar +1 more source
Multimodal Indoor Localisation in Parkinson's Disease for Detecting Medication Use: Observational Pilot Study in a Free-Living Setting [PDF]
Proceedings of the 29th ACM SIGKDD Conference on Knowledge
Discovery and Data Mining (KDD 2023), 2023 Parkinson's disease (PD) is a slowly progressive, debilitating neurodegenerative disease which causes motor symptoms including gait dysfunction. Motor fluctuations are alterations between periods with a positive response to levodopa therapy ("on") and periods marked by re-emergency of PD symptoms ("off") as the response to medication wears off.
arxiv +1 more source
Advances in Nutrition, 2021 Although levodopa remains the most effective drug for symptomatic management of Parkinson's Disease (PD), treatment during advanced disease stages may raise unpredictable motor fluctuations and other complications.
Jikke T Boelens Keun +3 more
semanticscholar +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background Patients with Parkinson's disease (PD) present various responsiveness to levodopa, but the cause of such differences in levodopa responsiveness is unclear. Previous studies related the damage of brain white matter (WM) to levodopa responsiveness in PD patients, but no study investigated the relationship between the structural brain ...
Juncong Du +11 more
wiley +1 more source
Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa
Brain : a journal of neurology, 2020 See Poewe and Espay (doi:10.1093/brain/awaa226) for a scientific commentary on this article. Cilia et al. describe the natural course of motor symptoms in drug-naïve patients with Parkinson’s disease and the effects of long-term levodopa on motor ...
R. Cilia +11 more
semanticscholar +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background Both progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) belong to atypical parkinsonian syndromes. It is important to differentiate these diseases accurately. We compared clinical outcomes and cognitive impairments between PSP and MSA. Methods Eighty‐five MSA parkinsonism type (MSA‐P) patients and 76 PSP patients
Peifei Jia +3 more
wiley +1 more source