Results 71 to 80 of about 95,577 (390)

Management of rapid eye movement sleep behavior disorder in patients with Parkinson's disease [PDF]

, 2016
Among all of the devastating effects that Parkinson’s disease (PD) has on an individual, sleep dysfunction is one that can have a profound effect on the entire family of the patient. The most potentially destructive of these sleep syndromes being that of
Jeffries, Michael
core   +1 more source

Silk‐Fibroin as Biocompatible and Bioresorbable Enzyme Immobilization Matrix for Screen‐Printed Amperometric Glucose Biosensors

Advanced Sensor Research, EarlyView.
Silk‐fibroin is applied as an immobilization matrix for a biocompatible and bioresorbable amperometric glucose biosensor. The immobilization matrix is optimized with regard to silk‐fibroin content, enzyme loading, and water solubility. The optimized silk‐fibroin matrix is compared to a BSA/glutaraldehyde‐based matrix.
Kevin A. Janus, Stefan Achtsnicht, Benedetta Isella, Alexander Kopp, Koichiro Miyamoto, Tatsuo Yoshinobu, Michael Keusgen, Michael J. Schöning   +7 more
wiley   +1 more source

Optimizing levodopa therapy for Parkinson’s disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective

Neuropsychiatric Disease and Treatment, 2008
David J BrooksDivision of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UKAbstract: After 40 years of clinical experience, levodopa remains the gold standard treatment for Parkinson’s disease (PD) despite ...
David J Brooks
doaj  

A phase I study to evaluate the effect of high-dose carbidopa on levodopa pharmacokinetics

Frontiers in Pharmacology
Levodopa is the gold standard treatment for Parkinson’s disease. However, a high unmet medical need exists for longer-lasting oral levodopa formulations to achieve sustained motor improvement with reduced risk of the effect wearing off.
Akane Hayashi, Atsushi Hosomi, Shinsaku Kihara, Masato Nishi, Saori Torisawa, Yoshiumi Ouchi, Hidenori Takada, Junichi Enokizono   +7 more
doaj   +1 more source

Catecholamine-Based Treatment in AD Patients: Expectations and Delusions. [PDF]

, 2015
In Alzheimer disease, the gap between excellence of diagnostics and efficacy of therapy is wide. Despite sophisticated imaging and biochemical markers, the efficacy of available therapeutic options is limited.
Alessandro eStefani, Alessandro eStefani, Atticus H Hainsworth, Claudio eLiguori, Enrica eOlivola, Giacoma eAngileri, Mariangela ePierantozzi, Salvatore eGalati, Valentina eSaviozzi, Vincenza eD’Angelo   +9 more
core   +3 more sources

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Levodopa-induced dyskinesia in Parkinson disease

Neurology, 2018
Objective To assess dyskinesia frequency in a population-based cohort of patients with Parkinson disease (PD). Dyskinesia complicates levodopa treatment and affects quality of life.
Pierpaolo Turcano, Michelle M. Mielke, J. Bower, J. E. Parisi, J. Cutsforth-Gregory, J. Ahlskog, R. Savica   +6 more
semanticscholar   +1 more source

A review of neuroleptic malignant syndrome : incidence and features in Malta [PDF]

, 1995
This paper describes Malta’s first sample of Neuroleptic Malignant Syndrome (NMS) and reviews the current literature. A retrospective sample of all diagnosed cases of NMS was reviewed using Pope’s (1986) criteria. Twelve cases were identified yielding an
Grech, Anton, Saliba, Joseph R.
core  

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Differences in Levodopa Response for Progressive and Non-Progressive Micrographia in Parkinson's Disease

Frontiers in Neurology, 2021
Background: Micrographia, one element of the dysgraphia of Parkinson's disease (PD), may be classified according to the presence or absence of a decremental pattern.
Poonam Zham, Poonam Zham, Sridhar A. Poosapadi, Sridhar A. Poosapadi, Peter Kempster, Peter Kempster, Sanjay Raghav, Sanjay Raghav, Kanae J. Nagao, Kitty Wong, Dinesh Kumar   +10 more
doaj   +1 more source