Results 91 to 100 of about 69,629 (300)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Levodopa influence on turning dynamics in people with Parkinson’s disease

Scientific Reports
Turning behaviors are affected in people with Parkinson’s disease (PwPD) leading to falls and Freezing of Gait (FOG). Levodopa therapy is commonly recommended for PwPD to help alleviate motor symptoms.
Lakshmi Pillai, Reid D. Landes, Tuhin Virmani   +2 more
doaj   +1 more source

Levodopa-induced dyskinesia in Parkinson disease: Current and Evolving Concepts. [PDF]

, 2018
Levodopa‐induced dyskinesia is a common complication in Parkinson disease. Pathogenic mechanisms include phasic stimulation of dopamine receptors, nonphysiological levodopa‐to‐dopamine conversion in serotonergic neurons, hyperactivity of corticostriatal ...
Ahlskog, Ahmed, Alcacer, Antonini, Barnum, Bastide, Bez, Bezard, Bezard, Bordia, Calabresi, Calabresi, Carlsson, Carta, Cerasa, Cerasa, Cerasa, Cerasa, Cilia, Durif, Durif, Elia, Espay, Espay, Fahn, Fahn, Fasano, Feyder, Fieblinger, Fiorentini, Fox, Fox, Fox, Freitas, Fuente-Fernandez, Garcia, Gardoni, Gerlach, Goetz, Goetz, Grandas, Gray, Grondin, Herz, Herz, Herz, Huang, Hung, Huot, Iderberg, Jones, Katzenschlager, Kimber, Kishore, Kleiner-Fisman, Kosillo, Krack, Laere, Lau, Lee, Lee, Lim, Litim, Mansouri, Mellone, Meloni, Merola, Morgante, Morgese, Mura, Nadjar, Niccolini, Nicoletti, Nutt, Olanow, Olanow, Pahwa, Parkinson Study Group, Pavon, Picconi, Politis, Porras, Potts, Prescott, Rocha, Rosa, Rosa, Roussakis, Ruzicka, Samadi, Santini, Shen, Sierra, Smith, Stanic, Stathis, Stelt, Suarez, Svenningsson, Swann, Tanaka, Thiele, Tison, Trenkwalder, Verhagen Metman, Whone, Wichmann, Wood, Yamamura   +108 more
core   +1 more source

Mapping Neurodegenerative Changes in Clinically Uncertain Parkinsonian Syndrome Patients Using Fast MR Spin TomogrAphy in Time‐Domain (MR‐STAT) Relaxometry at 3T

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MR Spin TomogrAphy in Time‐domain (MR‐STAT) enables accelerated multiparametric relaxometry (T1/T2). Previous relaxometry studies predominantly compared Parkinson's disease patients with healthy controls (HC). The potential of relaxometry to distinguish neurodegenerative from non‐neurodegenerative parkinsonism in clinically ...
Martin B. Schilder, Elon D. Wallert, Stefano Mandija, Oscar van der Heide, Hongyan Liu, Miha Fuderer, Edwin Versteeg, Jan Booij, Rob M. A. de Bie, Martijn Beudel, Henk W. Berendse, Tom van Mierlo, Jeroen Blankevoort, Cornelis A. T. van den Berg, Elsmarieke van de Giessen, Alessandro Sbrizzi   +15 more
wiley   +1 more source

Botulinum toxin type A for Holmes tremor secondary to thalamic hemorrhage [PDF]

, 2015
Holmes tremor (HT) is a low-frequency rest and intentional tremor frequently affecting the upper limb.
Giovannelli, Morena, Latino, Pamela, Orzi, Francesco, Pontieri, FRANCESCO ERNESTO   +3 more
core   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Goras Georgios, Thrasyvoulou Andreas, Tsilimpokou Evanthia   +2 more
wiley   +1 more source

Differential diagnostic relevance of high resolution magnetic resonance in patients with possible multiple system atrophy (MSA) – a case report [Važnost uporabe magnetne rezonancije visoke rezolucije u dijagnostici moguće multiple sistemske atrofije - prikaz slučaja] [PDF]

, 2011
Multiple system atrophy (MSA) is sporadic, progressive neurodegenerative disorder characterized clinically by autonomic dysfunction, Parkinsonism (MSA-P), and cerebellar ataxia (MSA-C) in any combination.
Bačić Baronica, Koraljka, Ivkić, Goran, Miličević, Goran, Ozretić, David   +3 more
core  

Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Clinical outcome assessments (COAs) are essential for evaluating symptom severity, treatment response, and disease progression in Parkinson's disease (PD). As clinical knowledge evolves, it is necessary to revisit the recommendation status on the COAs to ensure their continued relevance and validity. Objectives To provide an updated
Evita Papathoma, Panagiota Tsitsi, Nirosen Vijiaratnam, Camila Aquino, Stephen R. Duma, Norbert Kovacs, Kigocha Lameck Okeng'o, Aparna Wagle Shukla, Roongroj Bhidayasiri, Tiago A. Mestre, Alvaro Sanchez Ferro, Alberto J. Espay, Michelle H.S. Tosin, Matej Skorvanek, Ioanna Markaki   +14 more
wiley   +1 more source

Levodopa-Induced Changes in Electromyographic Patterns in Patients with Advanced Parkinson’s Disease

Frontiers in Neurology, 2018
Levodopa medication is the most efficient treatment for motor symptoms of Parkinson’s disease (PD). Levodopa significantly alleviates rigidity, rest tremor, and bradykinesia in PD.
Verneri Ruonala, Eero Pekkonen, Olavi Airaksinen, Markku Kankaanpää, Pasi A Karjalainen, Saara M Rissanen   +5 more
doaj   +1 more source