Results 111 to 120 of about 69,629 (300)

Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The Movement Disorder Society‐Unified Parkinson's Disease Rating Scale‐Part III (MDS‐UPDRS‐III) is subjective and insensitive to subtle changes in patients with Parkinson's disease (PD). Computer vision (CV) can extract objective kinematics from routine outpatient videos, potentially augmenting the accuracy of the motor assessment ...
Pasquale Maria Pecoraro, Luca Marsili, Antonio Cannavacciuolo, Kevin R. Duque, Jesus Abanto, Jennifer Sharma, Jennifer Scheler, Heba A. Deraz, Lauren Wingler, Vincenzo Di Lazzaro, Alberto J. Espay, Lazzaro di Biase, Matteo Bologna   +12 more
wiley   +1 more source

Acute Levodopa Challenge in Atypical Parkinsonism: Comprehensive Analysis of Individual Motor Responses

Brain Sciences
The acute levodopa challenge is widely used to distinguish Parkinson’s disease (PD) from atypical parkinsonian syndromes (APSs) such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP).
Lan Ye, Sam Sadeghi Sani, Linda Veith Sanches, Lea Farina Magdalena Krey, Florian Wegner, Matthias Höllerhage, Christoph Schrader, Günter Höglinger, Martin Klietz   +8 more
doaj   +1 more source

A Wavelet-Based Approach To Monitoring Parkinson's Disease Symptoms

, 2017
Parkinson's disease is a neuro-degenerative disorder affecting tens of millions of people worldwide. Lately, there has been considerable interest in systems for at-home monitoring of patients, using wearable devices which contain inertial measurement ...
Fixler, Naama, Resheff, Yehezkel S., Wagner, Avishai   +2 more
core   +1 more source

Considerations for Initiation and Maintenance of Foslevodopa/Foscarbidopa for Advanced Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background As Parkinson's disease (PD) progresses, motor fluctuations become increasingly difficult to manage with oral medications. Foslevodopa/foscarbidopa (LDp/CDp), delivered as a continuous 24‐h/day subcutaneous infusion, offers continuous levodopa delivery and stable plasma levodopa levels that reduce motor fluctuations. LDp/CDp has been
K. Ray Chaudhuri, Bruno Bergmans, Eric Freire‐Alvarez, Lucie Hopes, Drew S. Kern, Robert S. Kirsner, Giulia Lazzeri, Pedro Mendes‐Bastos, Noriko Nishikawa, Per Odin, Karolina Poplawska‐Domaszewicz, Rajesh Pahwa, Yuval Ramot, Klaus Seppi, Tobias Warnecke, Robert Wiggins, Megha B. Shah, Pavnit Kukreja, Bjoern Fritz, Koray Onuk, Stuart H. Isaacson   +20 more
wiley   +1 more source

Mitigating gut microbial degradation of levodopa and enhancing brain dopamine: Implications in Parkinson’s disease

Communications Biology
Parkinson’s disease is managed using levodopa; however, as Parkinson’s disease progresses, patients require increased doses of levodopa, which can cause undesirable side effects. Additionally, the oral bioavailability of levodopa decreases in Parkinson’s
Gang Cheng, Micael Hardy, Cecilia J. Hillard, Jimmy B. Feix, Balaraman Kalyanaraman   +4 more
doaj   +1 more source

Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats

Drug Design, Development and Therapy, 2012
Xinxin Yang,1,* Yinghui Chen,2,* Xiaoyun Hong,3 Na Wu,1 Lu Song,1 Weien Yuan,3 Zhenguo Liu11Department of Neurology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China; 2Department of Neurology, Jinshan ...
Song L,Yuan W, Wu N, Hong X, Chen Y, Yang X, Liu Z   +5 more
doaj  

Patient‐Reported Communication Decline Following Deep Brain Stimulation in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Objective decline in communication abilities following Deep Brain Stimulation (DBS) in People with Parkinson's disease (PwP) is common; however, patient perspectives remain under‐investigated. Objectives This study examined subjective change in communicative efficacy using the Communicative Participation Item Bank (CPIB) in PwP ...
Stephanie M. Simone, Federico Rodriguez‐Porcel, Travis H. Turner   +2 more
wiley   +1 more source

Impact of Istradefylline on Levodopa Dose Escalation in Parkinson’s Disease: ISTRA ADJUST PD Study, a Multicenter, Open-Label, Randomized, Parallel-Group Controlled Study

Neurology and Therapy
Introduction A higher levodopa dose is a risk factor for motor complications in Parkinson’s disease (PD). Istradefylline (IST) is used as adjunctive treatment to levodopa in PD patients with off episodes, but its impact on levodopa dose titration remains
Taku Hatano, Renpei Sengoku, Hiroshi Nagayama, Naotake Yanagisawa, Asako Yoritaka, Keisuke Suzuki, Noriko Nishikawa, Yohei Mukai, Kyoichi Nomura, Norihito Yoshida, Morinobu Seki, Miho Kawabe Matsukawa, Hiroo Terashi, Katsuo Kimura, Jun Tashiro, Shigeki Hirano, Hidetomo Murakami, Hideto Joki, Tsuyoshi Uchiyama, Hideki Shimura, Kotaro Ogaki, Jiro Fukae, Yoshio Tsuboi, Kazushi Takahashi, Toshimasa Yamamoto, Kenichi Kaida, Ryoko Ihara, Kazutomi Kanemaru, Osamu Kano   +28 more
doaj   +1 more source

High Accuracy Classification of Parkinson's Disease through Shape Analysis and Surface Fitting in $^{123}$I-Ioflupane SPECT Imaging

, 2017
Early and accurate identification of parkinsonian syndromes (PS) involving presynaptic degeneration from non-degenerative variants such as Scans Without Evidence of Dopaminergic Deficit (SWEDD) and tremor disorders, is important for effective patient ...
Ghosh, Shantanu, Mandal, Pravat K., Prashanth, R., Roy, Sumantra Dutta   +3 more
core   +1 more source

Voice and Speech in Atypical Parkinsonian Disorders

Movement Disorders Clinical Practice, EarlyView.
Background Motor speech disorders are early, common, and functionally limiting features of atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA). These impairments are underrecognized and undertreated in neurology clinics.
Federico Rodriguez‐Porcel, Farwa Ali, Michiko Bruno, Heather Davis Cuevas, Rohit Dhall, Kylie Dunne‐Platero, Lawrence I. Golbe, Ihtsham Haq, Nicole Herndon, Lawrence S. Honig, Kyurim Kang, Sarah Kremen, Guillaume Lamotte, Nikolaus R. McFarland, Michela Mir, Leila Montaser‐Kouhsari, Alexander Pantelyat, Joel Page, Hylan Pickett, Laura Purcell Verdun, Kelly Richardson, Jessica Shurer, Michelle Troche, Rene L. Utianski, Katya Villarreal‐Cavazos, Tuhin Virmani, Anne‐Marie Wills, as the Diagnosis and Treatment Working Group, CurePSP Center of Care (CoC) Network, Farwa Ali, Michiko Bruno, Timothy Chang, Rohit Dhall, Kimiko Domoto‐Reilly, Lawrence I. Golbe, Ihtsham Haq, Lawrence S. Honig, Sarah Kremen, Guillaume Lamotte, Zoltan Mari, Nikolaus R. McFarland, Leila Montaser‐Kouhsari, Alexander Pantelyat, Federico Rodriguez‐Porcel, Junaid Siddiqui, Jessica Shurer, Christopher Spears, Tuhin Virmani, Anne‐Marie Wills   +48 more
wiley   +1 more source