A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders
Movement Disorders, EarlyView.Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta +6 more
wiley +1 more source
Levodopa in early Parkinson's disease [PDF]
The aim of this thesis, ‘Levodopa in early Parkinson’s disease’ was to investigate a) whether levodopa has a beneficial disease modifying effect in Parkinson’s disease (PD) in a clinical trial, and to assess the related treatment costs, b) which lessons ...
Verschuur, C.V.M.
core +1 more source
Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study
Movement Disorders, EarlyView.Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri +13 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Plasma phosphorylated‐tau at threonine‐217 (p‐tau217) and threonine‐181 (p‐tau181) are scalable, minimally invasive biomarkers of Alzheimer's disease (AD) pathology. In Parkinson's disease (PD), AD co‐pathology may contribute to its clinical heterogeneity.
Eleonora Fiorenzato +16 more
wiley +1 more source
Levodopa and Subthalamic Nucleus Deep Brain Stimulation Modulate Excitation/Inhibition Balance and the Neural Encoding of Isochronous Sequences in Persons With Parkinson's Disease. [PDF]
Ann N Y Acad SciCriscuolo A +5 more
europepmc +1 more source
Movement Disorders Clinical Practice, EarlyView.
Ingrid Lorena da Silva Gomes +9 more
wiley +1 more source
Why Use Immersive Virtual Reality to Assess Gait in Functional Motor Disorders?
Movement Disorders, EarlyView.Abstract Background Functional motor disorders (FMD) are disabling conditions modulated by attentional demands. Immersive virtual reality (iVR) engages multiple attentional and sensory networks, but its application in people with FMD (PwFMD) remains limited.
Marialuisa Gandolfi +14 more
wiley +1 more source
Clarifying Problems in the Synthetic Pathway Towards Methylene-Type Levodopa Acylals as Potential Prodrugs. [PDF]
Arch Pharm (Weinheim)Keydel T, Theele Y, Link A.
europepmc +1 more source
Movement Disorders, EarlyView.Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota +14 more
wiley +1 more source
Effects of eating behavior patterns and dietary habits on the therapeutic efficacy of Parkinson's disease medications: from phenomena, mechanisms to clinical applications. [PDF]
Front NutrYe J +12 more
europepmc +1 more source