Results 151 to 160 of about 53,685 (285)

Effects of dietary factors on levodopa pharmacokinetics

, 2015
P. 633-642lmportance of the fíeld: Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic an d pharmacodynamic features of this drug.
Sahagún Prieto, Ana María, García Viéitez, Juan José, Sierra Vega, Matilde, Fernández Martínez, María Nélida, Díez Laiz, Raquel, Díez Liébana, María José   +5 more
core  

Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One‐Year Follow‐Up and Electric Field Simulations

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective To evaluate the effects of bilateral caudal zona incerta (cZi) deep brain stimulation (DBS) for Parkinson's disease (PD) one year after surgery and to create anatomical improvement maps based on patient‐specific simulation of the electric field.
Rasmus Stenmark Persson, Teresa Nordin, Gun‐Marie Hariz, Karin Wårdell, Lars Forsgren, Marwan Hariz, Patric Blomstedt   +6 more
wiley   +1 more source

Three Cases of Levodopa-Carbidopa Responsive Nocturnal Akinesis in Male Children of an Inbred Family in Rural Baluchistan, Pakistan. [PDF]

Int J Mol Sci
Akram J, Ghaffar A, Usmani MA, Shareef U, Ahmed ZM, Riazuddin S, Riazuddin S.   +6 more
europepmc   +1 more source

Controlled release levodopa treatment of motor fluctuations in Parkinson's disease.

, 1987
A controlled release preparation of levodopa-carbidopa, CR III, given every 4 hours to 17 Parkinsonian patients for up to 10 months reduced plasma drug variations and improved motor response fluctuations compared with standard levodopa-carbidopa given ...
FABBRINI, Giovanni, T. N. Chase, A. M. Kask, M. M. Mouradian, C. Serrati, J. L. Juncos   +5 more
core  

Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism

Movement Disorders, EarlyView.
Abstract Background Bilateral pallidal deep brain stimulation (GPi‐DBS) is effective for dystonia. Long‐term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives To assess 15‐year dystonia outcomes and characterize parkinsonism after bilateral GPi‐DBS.
Clément Desjardins, Cécilia Bonnet, Elena Moro, David Grabli, Valérie Fraix, Marie‐Laure Welter, Laurent Vercueil, Soledad Navarro, Carine Karachi, Thibaud Charrier, Sylvie Raoul, Mathilde Guibourd de Luzinais, Emmanuel Cuny, Stéphan Chabardes, Pierre Burbaud, Dominique Guehl, Pascal Derkinderen, Marie Vidailhet, on behalf of the French SPIDY Study Group, Olivier Detante, Valérie Fraix, Pierre Pollak, Laurent Vercueil, Yves Agid, David Grabli, Jean‐Luc Houeto, Valérie Mesnage, Marie Vidailhet, Marie‐Laure Welter, Pierre Césaro, Luc Defebvre, Alain Destée, Pierre Krystkowiak, Alim‐Louis Benabid, Stephan Chabardes, Adnan Koudsie, Philippe Cornu, Soledad Navarro, Serge Blond, Gustavo Touzet, Abdelhamid Benazzouz, Bernard Pidoux, François Cassim, Sylvie Grand, Jean‐François Le Bas, Didier Dormont, Jean‐Pierre Pruvo, Christine Delmaire, Claire Ardouin, Bernard Pillon, Valérie Hahn‐Barma, Kathy Dujardin.   +51 more
wiley   +1 more source

The Intraoperative Microlesion Effect Positively Correlates With the Short‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective During the surgical procedure of deep brain stimulation (DBS), insertion of an electrode in the subthalamic nucleus (STN) frequently causes a temporary improvement of motor symptoms, known as the microlesion effect (MLE). The objective of this study was to determine the correlation between the intraoperative MLE and the clinical ...
Stèfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost   +8 more
wiley   +1 more source

The site of absorption matters: Small bowel dysmotility and levodopa pharmacokinetics in Parkinson's disease. [PDF]

J Parkinsons Dis
Raphael KG, Corcos DM, Lamotte G.
europepmc   +1 more source

Dopamine‐Deficiency‐Related Reorganization of the Somatomotor Network in Prodromal and Early Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Introduction Network attack tolerance (NAT) measures the brain's ability to sustain information flow despite the loss of critical brain regions. In Parkinson's disease (PD), NAT has been linked to cognitive and motor function. However, it remains unclear how dopaminergic degeneration shapes NAT, and whether it relates to motor symptom ...
Adrian L. Asendorf, Verena Dzialas, Thilo van Eimeren, Merle C. Hoenig   +3 more
wiley   +1 more source

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive–Compulsive Disorder: A Systematic Review

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis, Annelien Duits, Mégan M. G. H. van de Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens   +7 more
wiley   +1 more source

Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1‐Associated Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individuals with Parkinson's disease (PD) carrying GBA1 variants often develop advanced motor complications that prompt evaluation for deep brain stimulation (DBS). However, concerns about accelerated cognitive decline after DBS in GBA1 carriers complicate clinical decision making.
Evridiki Asimakidou, Micol Avenali, Jan O. Aasly, Mitra Afshari, Roy N. Alcalay, Sharlet Anderson, Carlo Alberto Artusi, Bryan Bernard, Marco Bozzali, Susan Bressman, Giovanna Calandra‐Buonaura, Francesco Cavallieri, Roberto Cilia, Jean‐Christoph Corvol, Antoniangela Cocco, Rob M.A. de Bie, Debra Ehrlich, Roberto Eleopra, Thomas Foltynie, Alessio Di Fonzo, Giulia Giannini, Christopher Goetz, Deborah Hall, Joohi Jimenez‐Shahed, Leonardo Lopiano, Vanessa Lythe, Maria Chiara Malaguti, Francesca Mameli, Graziella Mangone, Karen Marder, M. Maral Mouradian, Augusto Rini, Luisa Sambati, Rachel Saunders‐Pullman, Vicki Lynn Shanker, Francesca Spagnolo, Marie‐Laure Welter, Roberta Zangaglia, Gian Pal, Enza Maria Valente, PARKNET Study Group, Giada Cuconato, Ilaria Palmieri, Alberto Imarisio, Pierfrancesco Mitrotti, Francesca Valentino, Claudio Pacchetti, Gabriele Imbalzano, Claudia Ledda, Silvia Gallo, Pietro Cortelli, Luca Baldelli, Ilaria Cani, Raffaella Minardi, Valerio Carelli, Franco Valzania, Edoardo Monfrini, Filippo Cogiamanian, Chiara Longo, Fabiana Colucci, Luigi M. Romito, Marco Liccari   +61 more
wiley   +1 more source