Results 81 to 90 of about 12,196 (247)
Levodopa-Induced Changes in Electromyographic Patterns in Patients with Advanced Parkinson’s Disease
Frontiers in Neurology, 2018 Levodopa medication is the most efficient treatment for motor symptoms of Parkinson’s disease (PD). Levodopa significantly alleviates rigidity, rest tremor, and bradykinesia in PD.
Verneri Ruonala +5 more
doaj +1 more source
The Clinical Development of Levodopa Inhalation Powder
, 2023 Oral levodopa is the most effective treatment for Parkinson disease, but OFF periods emerge over time. Gastrointestinal dysfunction and food effects impact levodopa absorption, contributing to unpredictable control of OFF periods. Inhaled levodopa powder
Waters, Cheryl H +4 more
core
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
, 2018 Vibhash D Sharma, Kelly E Lyons, Rajesh Pahwa Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA Abstract: Levodopa-induced dyskinesia (LID) is a common motor complication in patients with Parkinson’s disease on ...
Pahwa R, Lyons KE, Sharma VD
core
, 2023 Parkinson's disease is a neurodegenerative disorder characterized by the degenerationdopamine-producingcing neurons. The gold standard therfory of the diseasethe is administration of levodopa/cawhichopa that aims to replenish the missing dopamine in the
Adam Dagan, Shaked
core
iRADIOLOGY, EarlyView.Magnetic resonance imaging (MRI)‐guided dopamine transporter (DAT) radiomics combined with machine learning showed promising performance for predicting 4‐year motor progression in Parkinson's disease. Ensemble voting fusion markedly improved discrimination compared with individual base models, with stable predictive features mainly derived from ...
Xiaoxuan Fan +8 more
wiley +1 more source
Frontiers in Neurology, 2019 Parkinson's disease is the second-most common neurodegenerative disorder worldwide. Besides deciphering the mechanisms that underlie the etiology of the disease, it is important to elucidate the factors that influence the efficacy of the treatment ...
Sebastiaan P. van Kessel, Sahar El Aidy
doaj +1 more source
Onset and duration of effect of extended-release carbidopa-levodopa in advanced Parkinson’s disease
, 2018 Robert A Hauser,1 Aaron Ellenbogen,2 Sarita Khanna,3 Suneel Gupta,3 Nishit B Modi3 1Departments of Neurology, Molecular Pharmacology, and Physiology, University of South Florida, Tampa, FL, USA; 2Quest Research Institute, Bingham Farms, MI, USA; 3Impax ...
Hauser RA +4 more
core
Orthostatic stability with intravenous levodopa
, 2015 Intravenous levodopa has been used in a multitude of research studies due to its more predictable pharmacokinetics compared to the oral form, which is used frequently as a treatment for Parkinson’s disease (PD).
Siddiqi, Shan H +5 more
core +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background MR Spin TomogrAphy in Time‐domain (MR‐STAT) enables accelerated multiparametric relaxometry (T1/T2). Previous relaxometry studies predominantly compared Parkinson's disease patients with healthy controls (HC). The potential of relaxometry to distinguish neurodegenerative from non‐neurodegenerative parkinsonism in clinically ...
Martin B. Schilder +15 more
wiley +1 more source