Results 81 to 90 of about 53,685 (285)

Levodopa influence on turning dynamics in people with Parkinson’s disease

Scientific Reports
Turning behaviors are affected in people with Parkinson’s disease (PwPD) leading to falls and Freezing of Gait (FOG). Levodopa therapy is commonly recommended for PwPD to help alleviate motor symptoms.
Lakshmi Pillai, Reid D. Landes, Tuhin Virmani   +2 more
doaj   +1 more source

Contribution of dopaminergic polymorphisms to levodopa treatment response and drug concentration in Chinese patients with Parkinson’s disease

Clinical Parkinsonism & Related Disorders
Background: Levodopa is the mainstay of treatments for Parkinson’s disease (PD), but large heterogeneity exists in patient response. Pharmacogenetic studies highlighted that genetic factors may play a relevant influence in this drug response variability.
Xiaoqin He, Kai Shi, Chengjun Mo, Yi Zhang, Qin Xiao, Xiaodong Yang   +5 more
doaj   +1 more source

Cognitive, Motor and Oculomotor Contributions to the Trail Making Test in Progressive Supranuclear Palsy

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by motor, oculomotor and cognitive impairments. Yet disentangling cognitive deficits from motor and oculomotor dysfunction remains a diagnostic and methodological challenge.
Indira Garcia‐Cordero, Mohsen Hadian, Juan Camilo Vargas‐Gonzalez, Marta Monteiro, David Gold, Abeer Khoja, Alonso Morales‐Rivero, Blas Couto, David Tang‐Wai, Susan Fox, Gabor G. Kovacs, Anthony E. Lang, Maria Carmela Tartaglia   +12 more
wiley   +1 more source

Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats

, 2012
Xinxin Yang1*, Ruiyuan Zheng2*, Yunpeng Cai2, Meiling Liao2, Weien Yuan1,2, Zhenguo Liu11Department of Neurology, Xinhua Hospital (affiliated to Shanghai Jiaotong University School of Medicine), 2School of Pharmacy, Shanghai Jiaotong University, Shanghai,
Yang X, Liu Z, Zheng R, Cai Y, Liao M, Yuan W   +5 more
core  

Apathy in Parkinson's Disease: Distinguishing Overlapping Symptoms Via Network Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Anxiety, fatigue, and excessive daytime sleepiness (EDS) frequently co‐occur in Parkinson's disease (PD) and can influence the clinical determination of apathy. Objective To distinguish patient‐reported apathy from other non‐motor symptoms.
Joseph Seemiller, Abhimanyu Mahajan, Christopher B. Morrow, Joseph F. McGuire, Dawn Bowers, Kelly A. Mills, Gregory M. Pontone   +6 more
wiley   +1 more source

Levodopa-Induced Changes in Electromyographic Patterns in Patients with Advanced Parkinson’s Disease

Frontiers in Neurology, 2018
Levodopa medication is the most efficient treatment for motor symptoms of Parkinson’s disease (PD). Levodopa significantly alleviates rigidity, rest tremor, and bradykinesia in PD.
Verneri Ruonala, Eero Pekkonen, Olavi Airaksinen, Markku Kankaanpää, Pasi A Karjalainen, Saara M Rissanen   +5 more
doaj   +1 more source

Prevalence and Associations of Abnormal Levels of Vitamin B6 in People with Parkinson's Disease [PDF]

Mov Disord Clin Pract
Abstract Background In people with Parkinson's disease, abnormal levels of vitamin B6 may be associated with polyneuropathy and epileptic seizures, including medication‐refractory status epilepticus. Objectives To estimate the prevalence and explore associations of abnormal levels of vitamin B6 in people with Parkinson's disease.
Lizarraga K, Wang L, Mesmer H, Shah N, Barbosa W, Logigian E, McDermott M, Lang A.   +7 more
europepmc   +2 more sources

Levodopa-induced release of homocysteine from astrocytes.

, 2012
Levodopa treatment led to increase in extracellular concentration of homocysteine in a time-dependent manner (A and B). Release of homocysteine by levodopa treatment was also dependent on the number of astrocytes with the maximum level in the highest ...
Man-Jeong Paik (116734), Hyun Jung Park (116737), Young H. Sohn (116741), Jin Young Shin (116728), Phil Hyu Lee (116745), Young-Hwan Ahn (116731)   +5 more
core   +1 more source

7 T MRI Connectivity‐Guided Reprogramming Improves Deep Brain Stimulation Motor Outcome in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD). Using 7‐Tesla (7 T) MRI connectivity analysis to visualize the patient‐specific STN motor subdivision, we hypothesize that reprogramming patients who are stimulated outside of this subdivision can improve their ...
Yarit Wiggerts, Annabel van der Weide, Rick Schuurman, Pepijn van den Munckhof, Rob MA de Bie, Martijn Beudel, Maarten Bot   +6 more
wiley   +1 more source

NMDA receptor regulation of levodopa-induced behavior and changes in striatal G protein-coupled receptor kinase 6 and ß-arrestin-1 expression in parkinsonian rats

, 2013
Na Wu, Lu Song, Xinxin Yang, Weien Yuan, Zhenguo Liu Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China Background: Parkinson’s disease is a neurodegenerative ...
Song L, Yang X, Liu Z, Wu N, Yuan W
core