Results 71 to 80 of about 85,254 (227)

Genomic Insights Into Carbapenem‐Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019–2024)

Journal of Clinical Laboratory Analysis, EarlyView.
The primary mechanism of carbapenem resistance identified in pediatric CRKP‐BSI strains was the production of Class B metalloenzymes. We report, for the first time, an outbreak of bloodstream infections in a neonatal ward caused by the dissemination of NDM‐1‐producing ST25 K. pneumoniae.
Mingming Zhou, Xiucai Zhang, Zhenjie Chen, Chao Fang, Shixing Liu, Jintao Xia, Yining Zhao, Chenmei Zhang, Hongqiang Shen   +8 more
wiley   +1 more source

Predictors of Successful First-Line Helicobacter pylori Eradication with Fluoroquinolones in Pakistan: A Prospective Exploration of Demographic and Clinical Factors

Antibiotics
Growing antibiotic resistance complicates H. pylori eradication, posing a public health challenge. Inconclusive research on sociodemographic and clinical factors emphasizes the necessity for further investigations.
Sumaira Khadim, Iyad Naeem Muhammad, Tanveer Alam, Shahnaz Usman, Hina Rehman, Sajjad Haider   +5 more
doaj   +1 more source

Prophylactic levofloxacin to prevent infections in newly diagnosed symptomatic myeloma: the TEAMM RCT. [PDF]

, 2019
BACKGROUND: Myeloma causes profound immunodeficiency and recurrent serious infections. There are approximately 5500 new UK cases of myeloma per annum, and one-quarter of patients will have a serious infection within 3 months of diagnosis. Newly diagnosed
Bowcock, S, Dawkins, B, Drayson, MT, Dunn, JA, Hawkey, P, Higgins, H, Hulme, CT, Iqbal, G, Low, E, Meads, D, Planche, T, Pratt, G, Raynes, K, Whittaker, AC, Wood, J, Yong, K   +15 more
core   +9 more sources

Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative

Journal of Hospital Medicine, EarlyView.
Abstract Background Evidence suggests a 3‐day total duration and early transition to oral therapy is safe in hospitalized patients with community acquired pneumonia (CAP)—though such care is not standard in the United States. To implement these evidence‐based practices, a multidisciplinary group led by a hospitalist and antimicrobial stewardship ...
Claire E. Ciarkowski, Karen Howard, Hannah Imlay, Chaorong Wu, Christy L. Hopkins, Valerie M. Vaughn, Emily S. Spivak   +6 more
wiley   +1 more source

Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown, Caron, Cars, Cars, Collignon, Dagan, DiNubile, Drlica, Essack, Fox, Geli, Goren, Gould, Guillemot, Harris, Hurdle, Huttner, Isha, Madurell, Masterton, Michalsen, Mitchison, Mitchison, Molstad, Sharma, Solapure, Talbot, Thomas   +27 more
core   +2 more sources

Ultrasound‐Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer

Journal of Ultrasound in Medicine, EarlyView.
Background Ultrasound‐guided prostate biopsy is the standard method for the diagnosis of prostate cancer. However, the effect of the optimal puncture approach on diagnostic yield and patient outcomes remains controversial. Objective To compare the diagnostic effectiveness and clinical outcomes of ultrasound‐guided transperineal versus transrectal ...
Yue Cao, Hong Zhu, Junwei Wu
wiley   +1 more source

Meropenem Prevents Levofloxacin-Induced Resistance in Penicillin-Resistant Pneumococci and Acts Synergistically with Levofloxacin in Experimental Meningitis [PDF]

, 2018
The aim of the present study was to investigate the potential synergy between meropenem and levofloxacin in vitro and in experimental meningitis and to determine the effect of meropenem on levofloxacin-induced resistance in vitro. Meropenem increased the
Acosta, F., Cottagnoud, M., Cottagnoud, P., Entenza, J., Flatz, L., Kühn, F., Stucki, A.   +6 more
core  

Novel reference gene microseminoprotein‐beta based prostate cancer antigen 3 urine test: Enhanced diagnostic performance for prostate cancer and feasibility of non‐digital rectal examination urine sampling

UroPrecision, EarlyView.
Abstract Background The diagnosis of prostate cancer (PCa) is limited by low specificity and invasiveness. This study aims to establish a highly accurate, noninvasive reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR)‐based urinary prostate cancer antigen 3 (PCA3) assay system and explore the feasibility of using first‐morning urine
Jianglei Xu, Lu Yang, Cong Shi, Yiwei Jiang, Jing Chen, Xiaoxiao Sun, Xuejuan Gao, Xian Wang, Jianzhong Jiang, Xiuzhi Duan, Xuchu Wang, Yiyi Xie, Zhixian Yu, Zhihua Tao, Xiaobing Dou, Chunyu Jin   +15 more
wiley   +1 more source

Detecting Efflux Pumps Genes in the Fluoroquinolones Resistant and Sensitive Strains of Escherichia coli in Patients with Urinary Tract Infection in Qom, Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objectives: Efflux pumps are among the main mechanisms for antibiotic resistance in Escherichia coli (E.coli) strains. The present study aimed to investigate the relationship between 5 efflux pump genes; acrA, acrB, emrA, emrB, and mdtk ...
Ebrahim Eshaghi, Alireza Shahvaroughi farahani, Sara Mousaei, Mohammad Khalifeh-Gholi, Jafar Adnani Sadati, Roohollah Fateh   +5 more
doaj  

Covalent modification of a ten-residue cationic antimicrobial peptide with levofloxacin

Frontiers in Chemistry, 2014
The rampant spread of antibiotic resistant bacteria has spurred interest in alternative strategies for developing next-generation antibacterial therapies.
Carlos Alberto Rodriguez, Emilios Andreas Papanastasiou, Melanie eJuba, Barney eBishop   +3 more
doaj   +1 more source