Results 91 to 100 of about 9,011 (201)

Levosimendan in Cardiac Surgery

Journal of Cardiothoracic and Vascular Anesthesia, 2005
Levosimendan is a new calcium sensitizer with inodilatory properties. There is growing clinical experience with levosimendan given to cardiac surgical patients. The aim of this report was to evaluate the effects of perioperative use of levosimendan in surgical patients with high perioperative risk, compromised left ventricular (LV) function, or ...
Harjola, V, Siirilä, K, Suojaranta-Ylinen, R   +2 more
openaire   +2 more sources

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study - A Randomized Clinical Trial [PDF]

, 2016
Background: Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on dogs before the onset of CHF is unknown.
Abbott, J A, Barrett, K A, Bomassi, E, Bonagura, J D, Boswood, A, Church, W M, Deinert, M, Del Palacio, M J F, Estrada, A H, Fox, P R, Fujii, Y, Gordon, S G, Haggstrom, J, Jaudon, J P, Keene, B W, Kresken, J G, Ljungvall, I, Luethy, M W, MacDonald, K A, Menaut, P, Moise, N S, O'Sullivan, M L, Oyama, M A, Patteson, M, Rosenthal, S L, Rush, J, Sanderson, K, Santilli, R A, Saunders, A B, Smith, S, Spier, A, Stepien, R L, Szatmari, V, Tidholm, A, Uechi, M, Watson, P, Wess, G, Woolley, R   +37 more
core   +3 more sources

Muscle Fatigue from the Perspective of a Single Crossbridge [PDF]

, 2016
The repeated intense stimulation of skeletal muscle rapidly decreases its force- and motion-generating capacity. This type of fatigue can be temporally correlated with the accumulation of metabolic by-products, including phosphate (Pi) and protons (H ...
Debold, Edward Patrick, Fitts, Robert H., Nosek, Thomas M., Sundberg, Christopher W.   +3 more
core   +1 more source

Cardiac Calcitropes, Myotropes, and Mitotropes: JACC Review Topic of the Week. [PDF]

, 2019
The term "inotrope" is familiar and intimately connected with pharmaceuticals clinically used for treatment of low cardiac output with cardiogenic shock.
Adams, KF, Allen, LA, Francis, GS, Gottlieb, SS, Lancellotti, P, Psotka, MA, Rosano, GMC, Teerlink, JR   +7 more
core   +2 more sources

Levosimendan does not reduce the mortality of critically ill adult patients with sepsis and septic shock: a meta-analysis

Chinese Medical Journal, 2019
. Background:. Previous studies on whether or not levosimendan improved the prognosis of patients with sepsis and septic shock have been inconsistent. We aimed to provide an updated analysis of the therapeutic value of levosimendan in adult patients with
Fang Feng, Yu Chen, Min Li, Jiao-Jiao Yuan, Xue-Ni Chang, Chen-Ming Dong, Li-Min Chen   +6 more
doaj   +1 more source

Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe? [PDF]

, 2018
Aims: Changes in systolic blood pressure (SBP) during an admission for acute heart failure (AHF), especially those leading to hypotension, have been suggested to increase the risk for adverse outcomes.
Bourge, Robert C., Cleland, John G.F., Cotter, Gad, Davison, Beth A., Edwards, Christopher, Jondeau, Guillaume, Kobrin, Isaac, McMurray, John J.V., Metra, Marco, Milo, Olga, O'Connor, Christopher M., Parker, John D., Rainisio, Maurizio, Senger, Stefanie, Teerlink, John R., Torre-Amione, Guillermo, van Veldhuisen, Dirk J.   +16 more
core   +3 more sources

eComment. Consider trying levosimendan [PDF]

Interactive CardioVascular and Thoracic Surgery, 2013
Levosimendan is a well established drug used nowadays routinely for the treatment of heart failure both in cardiology [1] as well as in cardiac surgery [2] despite the relatively high costs of administration [3] and the few, one must admit, adverse effects [4]. The review article by Angadi et al.
openaire   +2 more sources

Transdermal delivery of levosimendan

European Journal of Pharmaceutical Sciences, 2000
The aim of this study was to determine if transdermal penetration of levosimendan, a novel positive inotropic drug, could be enhanced and controlled by formulation modifications. Penetration of levosimendan across human epidermis in vitro was determined using abdominal excised skin and diffusion cells.
R, Valjakka-Koskela, J, Hirvonen, J, Mönkkönen, J, Kiesvaara, S, Antila, L, Lehtonen, A, Urtti   +6 more
openaire   +2 more sources

Levosimendan as rescue therapy in low output syndrome after cardiac surgery: effects and predictors of outcome

Journal of International Medical Research, 2019
Objectives Calcium sensitizers have been shown to improve outcomes in patients with low cardiac output syndrome (LCOS) after cardiac surgery. We assessed the effects of levosimendan on LCOS in cardiac surgical patients to identify outcome predictors ...
Andres Beiras-Fernandez, Angela Kornberger, Martin Oberhoffer, Felix Kur, Marion Weis, Christian-Friedrich Vahl, Florian Weis   +6 more
doaj   +1 more source

An In Vitro Investigation of the Antiproliferative and Antimetastatic Effects of Levosimendan: Potential Drug Repurposing for Cervical Cancer

Current Issues in Molecular Biology
Cervical cancer presents a significant challenge to the global health of women. Despite substantial advances in human papillomavirus (HPV)-related cervical cancer vaccines, non-HPV-related cervical cancer is still waiting novel therapeutic options.
Zsuzsanna Schelz, Hiba F. Muddather, Fatemeh Sheihaki Jaski, Noémi Bózsity, István Zupkó   +4 more
doaj   +1 more source