Results 101 to 110 of about 12,502 (244)

Worsening versus advanced heart failure: Management and challenges

ESC Heart Failure, Volume 12, Issue 6, Page 3856-3868, December 2025.
Clinical feature, circulating biomarkers and therapeutic management of patients with WHF versus AdvHF. Abbreviations: AdvHF, advanced heart failure; HF, heart failure; HTx, heart transplant; GDMT, guideline‐directed medical therapy; MCS, mechanical circulatory support; NYHA, New York Heart Association; WHF, worsening heart failure.
Alberto Palazzuoli, Marco Giuseppe Del Buono, Giulia La Vecchia, Stephen J. Greene, Andrew P. Ambrosy, Ovidiu Chioncel, Finn Gustafsson, Selim R. Krim, Carl J. Lavie, Marianna Adamo, Tuvia Ben Gal, Oliviana Geavlete, Laura Antohi, Giuseppe Rosano, Sean Collins, Filippo Crea   +15 more
wiley   +1 more source

Predictivity of in vitro non-clinical cardiac contractility assays for inotropic effects in humans – A Literature Search [PDF]

, 2015
Adverse drug effects on the cardiovascular system is a major cause of compound attrition throughout compound discovery and development. There are many ways by which drugs can affect the cardiovascular system, including effects on the electrocardiogram ...
Gharanei, Mayel, Maddock, Helen L., Wallis, R.   +2 more
core   +1 more source

Levosimendan as a new force in the treatment of sepsis-induced cardiomyopathy: mechanism and clinical application

Journal of International Medical Research, 2019
The heart is one of the organs most vulnerable to sepsis. This review describes the general characteristics of sepsis-induced cardiomyopathy and the main pathogenesis of myocardial dysfunction in sepsis.
Fei Yang, Li Na Zhao, Yi Sun, Zhuang Chen   +3 more
doaj   +1 more source

Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats

Toxicology Reports, 2019
We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second groups received normal saline (control) and intraperitoneal (i.p.) cisplatin (6 mg/kg) on day 7 ...
Aly M. Abdelrahman, Yousuf Al Suleimani, Asem Shalaby, Mohammed Ashique, Priyadarsini Manoj, Hasna Al-Saadi, Badreldin H. Ali   +6 more
doaj   +1 more source

Levosimendan versus dobutamine for sepsis-induced cardiac dysfunction: a systematic review and meta-analysis

Scientific Reports, 2021
Levosimendan and dobutamine are extensively used to treat sepsis-associated cardiovascular failure in ICU. Nevertheless, the role and mechanism of levosimendan in patients with sepsis-induced cardiomyopathy remains unclear.
Dong-Hua Liu, Yi-Le Ning, Yan-Yan Lei, Jing Chen, Yan-Yan Liu, Xin-Feng Lin, Zhong-Qi Yang, Shao-Xiang Xian, Wei-Tao Chen   +8 more
doaj   +1 more source

Haemodynamic effects of istaroxime in SCAI stage B HF‐related cardiogenic shock: Insights from the SEISMiC trial

ESC Heart Failure, Volume 12, Issue 6, Page 3966-3975, December 2025.
Among patients with ADHF‐related SCAI stage B CS enrolled in SEISMiC, istaroxime at doses up to 1.0 μg/kg/min for up to 60 h was associated with sustained improvements in aortic pulsatility index and LV stroke work index, and with increase of PA compliance and reduction in PA elastance at 48 h.
Matteo Pagnesi, Gad Cotter, Beth Davison, Daniel Burkhoff, Alexander Mebazaa, Jan Biegus, Ovidiu Chioncel, Christopher Edwards, Koji Takagi, Gerasimos Filippatos, Agnieszka Tycińska, Maria Novosadova, Gaurav Gulati, Marianela Barros, Maria Luz Diaz, Carlos Guardia, Robert Zymliński, Piotr Gajewski, Piotr Ponikowski, Phillip Simmons, Steven Simonson, Marco Metra   +21 more
wiley   +1 more source

İleri kalp yetersizliği hastalarında levosimendanın eritrosit dağılım genişliği üzerine etkisi

Genel Tıp Dergisi, 2015
Amaç: Levosimendan dekompanse kalp yetersizliğinde kullanılan, olumlu hemodinamik etkileri de olan pozitif inotropik bir ilaçtır. Bu çalışmanın amacı levosimendan tedavisi almış ileri kalp yetersizliği hastalarının tedavi öncesi ve sonrası eritrosit ...
Ahmet Gürel, Niyazi Güler, Murat Aydın, Şeref Alpsoy, Aydın Akyüz, Dursun Çayan Akkoyun   +5 more
doaj  

Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: a prospective randomized controlled trial

Critical Care, 2019
Background The administration of levosimendan prophylactically to patients undergoing cardiac surgery remains a controversial practice, and few studies have specifically assessed the value of this approach in pediatric patients.
Anbiao Wang, Chaomei Cui, Yiou Fan, Jie Zi, Jie Zhang, Guanglai Wang, Fang Wang, Jun Wang, Qi Tan   +8 more
doaj   +1 more source

Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart

BMC Anesthesiology, 2018
Background Successful resuscitation from asystole induced by bupivacaine requires the reestablishment of a sufficient coronary flow (CF) quickly. This study was designed to test whether levosimendan was superior to epinephrine in the reestablishment of ...
Hongfei Chen, Fangfang Xia, Zhousheng Jin, Kejian Shi, Yun Xia, Le Liu, Thomas J. Papadimos, Xuzhong Xu, Limei Chen   +8 more
doaj   +1 more source

Anesthetic Management for Pituitary Tumor Resection in a Patient With Acromegalic Cardiomyopathy: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Acromegalic cardiomyopathy is one of the common comorbidities of cardiovascular diseases in patients with acromegaly, and it is also a major risk factor affecting the survival rate of patients with acromegaly. The perioperative management of such patients is a challenge for anesthesiologists.
Shuting Yang, Mi Wang
wiley   +1 more source