Results 11 to 20 of about 12,531 (249)

Levosimendan: a cardiovascular drug to prevent liver ischemia-reperfusion injury? [PDF]

PLoS ONE, 2013
INTRODUCTION: Temporary occlusion of the hepatoduodenal ligament leads to an ischemic-reperfusion (IR) injury in the liver. Levosimendan is a new positive inotropic drug, which induces preconditioning-like adaptive mechanisms due to opening of ...
Peter Onody, Rita Stangl, Andras Fulop, Oliver Rosero, David Garbaisz, Zsolt Turoczi, Gabor Lotz, Zoltan Rakonczay, Zsolt Balla, Viktor Hegedus, Laszlo Harsanyi, Attila Szijarto   +11 more
doaj   +5 more sources

Levosimendan in Sepsis [PDF]

New England Journal of Medicine, 2017
Commentum to "Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis"
Putzu A, Belletti A, ZANGRILLO, ALBERTO
openaire   +14 more sources

Levosimendan in Cardiac Arrest (LeiCA): Protocol for a Randomized, Double-Blind, Phase II Clinical Trial. [PDF]

Acta Anaesthesiol Scand
ABSTRACT Background Despite developments in advanced life support, outcomes after out‐of‐hospital cardiac arrest (OHCA) remain poor. Levosimendan, a calcium‐sensitizing inodilator commonly used in heart failure, has shown beneficial effects in several experimental models and anecdotal clinical cases of cardiac arrest. The Levosimendan in Cardiac Arrest
Rysz S, Flam B, Hedberg M, Galmén K, Mårtensson J, Djärv T, Jonsson Fagerlund M.   +6 more
europepmc   +2 more sources

Successful Use of Levosimendan in Four Critically Ill Neonates With Pulmonary Hypertension: A Case Series. [PDF]

Pediatr Pulmonol
Pediatric Pulmonology, Volume 60, Issue 12, December 2025.
Kantzavelou A, Chatzigiannis N, Baltogianni M, Atzemoglou N, Giapros V.   +4 more
europepmc   +2 more sources

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation. [PDF]

Adv Sci (Weinh)
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Zhao R, Sun B, Wei P, Sun Y, He Q, Zhang K, Lu J, Zhu S, Yang Y, Guo Z.   +9 more
europepmc   +2 more sources

Impact of Pre-Heart Transplant Levosimendan Administration on Post-Transplant Vasoplegia and Primary Graft Dysfunction. [PDF]

Clin Transplant
ABSTRACT Introduction Levosimendan, a calcium‐sensitizing inotropic agent, is used in patients with advanced heart failure (HF) awaiting heart transplantation (HT). Its prolonged effects, due to an active metabolite, may influence post‐transplant vasodilation, particularly when administered shortly before HT.
Guzman-Bofarull J, Martín-Centellas A, Couto-Mallon D, Borràs R, Arenas-Loriente A, Rivas-Lasarte M, Segovia-Cubero J, Crespo-Leiro MG, García-Álvarez A, Farrero M.   +9 more
europepmc   +2 more sources

Effect of levosimendan on plasma intestinal barrier factors in heart failure patients with reduced ejection fraction. [PDF]

Zhong Nan Da Xue Xue Bao Yi Xue Ban
Wu Y, Hu X, Mao X, Liu H, Li S, Zeng Y, Xu P, Xiao H, Li D, Xia K.   +9 more
europepmc   +3 more sources

Prevention of acute kidney injury and protection of renal function in the intensive care unit : update 2017 [PDF]

, 2017
Background: Acute kidney injury (AKI) in the intensive care unit is associated with significant mortality and morbidity. Objectives: To determine and update previous recommendations for the prevention of AKI, specifically the role of fluids, diuretics ...
Druml, W, Forni, LG, Groeneveld, ABJ, Honore, PM, Hoste, Eric, Joannidis, M, Ostermann, M, Oudemans-van Straaten, HM, Schetz, Mathias   +8 more
core   +15 more sources

The Effects of the Levosimendan Metabolites OR-1855 and OR-1896 on Endothelial Pro-Inflammatory Responses

Biomedicines, 2023
The calcium sensitizer levosimendan is used for the treatment of acute decompensated heart failure. A small portion (4–7%) of levosimendan is metabolized to the pharmacologically active metabolite OR-1896 via the inactive intermediate OR-1855.
Hannah Kipka, Rebecca Schaflinger, Roland Tomasi, Kristin Pogoda, Hanna Mannell   +4 more
doaj   +1 more source

Influence of timing of Levosimendan administration on outcomes in cardiac surgery

Frontiers in Cardiovascular Medicine, 2023
PurposeThough a subgroup analysis has shown improved survival for patients suffering severely reduced ventricular function undergoing coronary artery bypass grafting, RCTs were not able to demonstrate overall beneficial effects of perioperative ...
Fridtjof Schiefenhövel, Fridtjof Schiefenhövel, Fridtjof Schiefenhövel, Christian Berger, Liubov Penkova, Herko Grubitzsch, Bernhard Haller, Alexander Meyer, Alexander Meyer, Matthias Heringlake, Michael Sander, Joachim M. Erb, Felix Balzer, Sascha Treskatsch   +13 more
doaj   +1 more source