Results 21 to 30 of about 6,081 (225)

Impact of levosimendan on efficacy and renal function in acute heart failure according to renal function: A perspective, multi-center, real-world registry

Frontiers in Cardiovascular Medicine, 2022
ObjectiveAcute heart failure (AHF) is associated with high mortality. Levosimendan, an inodilator, has proved to increase cardiac output and exert renoprotective effect in AHF.
Han Zhang, Li Jiang, Rui Fu, Ping Qin, Xuan Zhang, Tao Tian, Guang-xun Feng, Yan-min Yang   +7 more
doaj   +1 more source

Single-center experience with levosimendan in children undergoing cardiac surgery and in children with decompensated heart failure

BMC Anesthesiology, 2011
Background Levosimendan has pharmacologic and hemodynamic advantages over conventional intravenous inotropic agents. It has been used mainly as a rescue drug in the pediatric intensive care unit or in the operating room.
Suominen Pertti K
doaj   +1 more source

Levosimendan: Perpetuum mobile? [PDF]

European Heart Journal, 2007
We read with great interest the well-written review about levosimendan by De Luca et al. 1 Levosimendan is certainly an interesting drug that appears to deliver favourable effects in patients with acute heart failure. Numerous studies have demonstrated the positive inotropic …
Dan Atar, Stefan Agewall
openaire   +3 more sources

Levosimendan reduces segmental pulmonary vascular resistance in isolated perfused rat lungs and relaxes human pulmonary vessels.

PLoS ONE, 2020
INTRODUCTION:Levosimendan is approved for acute heart failure. Within this context, pulmonary hypertension represents a frequent co-morbidity. Hence, the effects of levosimendan on segmental pulmonary vascular resistance (PVR) are relevant.
Annette Dorothea Rieg, Said Suleiman, Nina Andrea Bünting, Eva Verjans, Jan Spillner, Heike Schnöring, Sebastian Kalverkamp, Thomas Schröder, Saskia von Stillfried, Till Braunschweig, Gereon Schälte, Stefan Uhlig, Christian Martin   +12 more
doaj   +1 more source

Levosimendan: a cardiovascular drug to prevent liver ischemia-reperfusion injury? [PDF]

PLoS ONE, 2013
INTRODUCTION: Temporary occlusion of the hepatoduodenal ligament leads to an ischemic-reperfusion (IR) injury in the liver. Levosimendan is a new positive inotropic drug, which induces preconditioning-like adaptive mechanisms due to opening of ...
Peter Onody, Rita Stangl, Andras Fulop, Oliver Rosero, David Garbaisz, Zsolt Turoczi, Gabor Lotz, Zoltan Rakonczay, Zsolt Balla, Viktor Hegedus, Laszlo Harsanyi, Attila Szijarto   +11 more
doaj   +1 more source

Treatment with levosimendan in an experimental model of early ventilator-induced diaphragmatic dysfunction

Drug Target Insights, 2023
Introduction: Mechanical ventilation (MV) is a life-saving approach in critically ill patients. However, it may affect the diaphragmatic structure and function, beyond the lungs.
Vanessa Zambelli, Emma J. Murphy, Paolo Del Vecchio, Laura Rizzi, Roberto Fumagalli, Emanuele Rezoagli, Giacomo Bellani   +6 more
doaj   +1 more source

Pre-admission beta-blocker therapy and outcomes in cardiogenic shock: Insights from the Altshock-2 Registry. [PDF]

ESC Heart Fail
Among 668 with cardiogenic shock included in the multicentre prospective Altshock‐2 registry, 299 patients (44.8%) received pre‐admission beta‐blocker therapy. Previous beta‐blocker therapy influenced the early hemodynamic response to vasoactive drugs, but it was not associated with in‐hospital mortality.
Pagnesi M, Riccardi M, Sacco A, Tavecchia G, Viola G, Frea S, Briani M, Bertoldi LF, Bertaina M, Potena L, Valente S, Marini M, De Ferrari GM, D'Ettore N, Cardinale A, Camporotondo R, Rota M, Tavazzi G, Morici N, Pappalardo F, Metra M, Altshock‐2 investigators.   +21 more
europepmc   +2 more sources

Comparison of Levosimendan, Milrinone and Dobutamine in treating Low Cardiac Output Syndrome Following Valve Replacement Surgeries with Cardiopulmonary Bypass [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Low Cardiac Output Syndrome (LCOS) following Cardiopulmonary Bypass (CPB) is common and associated with increased mortality. Maintenance of adequate cardiac output is one of the primary objectives in management of such patients. Aim: To
Sunny, Mohd Yunus, Habib Md Reazaul Karim, Manuj Kumar Saikia, Prithwis Bhattacharyya, Samarjit Dey   +5 more
doaj   +1 more source

The Perioperative Use of Levosimendan as a Means of Optimizing the Surgical Outcome in Patients with Severe Heart Insufficiency Undergoing Cardiac Surgery

Journal of Cardiovascular Development and Disease, 2023
Background: Postoperative myocardial dysfunction following cardiac surgery is a relatively common occurrence. Levosimendan, a calcium sensitizer and inotropic drug, has shown potential in improving outcomes for patients with low preoperative ejection ...
Vasileios Leivaditis, Konstantinos Grapatsas, Anastasia Papaporfyriou, Michail Galanis, Efstratios Koletsis, Nikolaos Charokopos, Erich Haussmann, Vladislav Kaplunov, Athanasios Papatriantafyllou, Manfred Dahm   +9 more
doaj   +1 more source

Use of levosimendan in hemodynamic management of heart failure in two neonates with intracranial arteriovenous shunts: a case series

Italian Journal of Pediatrics, 2023
Background The hemodynamic status of newborns with intracranial arteriovenous shunts (AVSs) may be extremely complex. Mini-invasive hemodynamic monitoring through innovative techniques such as Near-Infrared Spectroscopy (NIRS) and Pressure Recording ...
Francesca Landolfo, Paola Giliberti, Domenico Umberto De Rose, Flaminia Pugnaloni, Alessandra Santisi, Claudia Columbo, Ludovica Martini, Maria Paola Ronchetti, Luca Di Chiara, Alessandra Toscano, Carlo Gandolfo, Andrea Dotta, Irma Capolupo   +12 more
doaj   +1 more source