Results 61 to 70 of about 12,531 (249)

Meta-Analysis of Placebo-Controlled Trials of Levosimendan in Acute Myocardial Infarction

Journal of Cardiovascular Development and Disease, 2021
The treatment of acute myocardial infarction is early revascularization. Heart failure and cardiogenic shock may complicate acute myocardial infarction despite applying the best available strategy.
Gabriele Tumminello, Alberto Cereda, Lucia Barbieri, Giuseppe Biondi-Zoccai, Stefano Lucreziotti, Antonio Mafrici, Stefano Carugo   +6 more
doaj   +1 more source

Worsening versus advanced heart failure: Management and challenges

ESC Heart Failure, Volume 12, Issue 6, Page 3856-3868, December 2025.
Clinical feature, circulating biomarkers and therapeutic management of patients with WHF versus AdvHF. Abbreviations: AdvHF, advanced heart failure; HF, heart failure; HTx, heart transplant; GDMT, guideline‐directed medical therapy; MCS, mechanical circulatory support; NYHA, New York Heart Association; WHF, worsening heart failure.
Alberto Palazzuoli, Marco Giuseppe Del Buono, Giulia La Vecchia, Stephen J. Greene, Andrew P. Ambrosy, Ovidiu Chioncel, Finn Gustafsson, Selim R. Krim, Carl J. Lavie, Marianna Adamo, Tuvia Ben Gal, Oliviana Geavlete, Laura Antohi, Giuseppe Rosano, Sean Collins, Filippo Crea   +15 more
wiley   +1 more source

Cardiovascular drug therapy for human newborn: review of pharmacodynamic data [PDF]

, 2017
BACKGROUND: Circulatory failure in preterm and term newborn infants is commonly treated with inotropes or vasoactive medications. In this structured literature review, the available data on pharmacodynamic effects of the inotropes adrenaline ...
Bravo, MC, Ergenekon, E, Kotidis, C, Mahoney, Liam, Rabe, Heike, Rojas-Anaya, H   +5 more
core   +1 more source

Haemodynamic effects of istaroxime in SCAI stage B HF‐related cardiogenic shock: Insights from the SEISMiC trial

ESC Heart Failure, Volume 12, Issue 6, Page 3966-3975, December 2025.
Among patients with ADHF‐related SCAI stage B CS enrolled in SEISMiC, istaroxime at doses up to 1.0 μg/kg/min for up to 60 h was associated with sustained improvements in aortic pulsatility index and LV stroke work index, and with increase of PA compliance and reduction in PA elastance at 48 h.
Matteo Pagnesi, Gad Cotter, Beth Davison, Daniel Burkhoff, Alexander Mebazaa, Jan Biegus, Ovidiu Chioncel, Christopher Edwards, Koji Takagi, Gerasimos Filippatos, Agnieszka Tycińska, Maria Novosadova, Gaurav Gulati, Marianela Barros, Maria Luz Diaz, Carlos Guardia, Robert Zymliński, Piotr Gajewski, Piotr Ponikowski, Phillip Simmons, Steven Simonson, Marco Metra   +21 more
wiley   +1 more source

Levosimendan as a new force in the treatment of sepsis-induced cardiomyopathy: mechanism and clinical application

Journal of International Medical Research, 2019
The heart is one of the organs most vulnerable to sepsis. This review describes the general characteristics of sepsis-induced cardiomyopathy and the main pathogenesis of myocardial dysfunction in sepsis.
Fei Yang, Li Na Zhao, Yi Sun, Zhuang Chen   +3 more
doaj   +1 more source

Inhibition of reverse-mode sodium-calcium exchanger activity and apoptosis by levosimendan in human cardiomyocyte progenitor cell-derived cardiomyocytes after anoxia and reoxygenation. [PDF]

PLoS ONE, 2014
Levosimendan, a known calcium sensitizer with positive inotropic and vasodilating properties, might also be cardioprotective during ischemia-reperfusion (I/R) insult. Its effects on calcium homeostasis and apoptosis in I/R injury remain unclear. Na(+)/Ca(
Ping-Chun Li, Ya-Chi Yang, Guang-Yuh Hwang, Lung-Sen Kao, Ching-Yuang Lin   +4 more
doaj   +1 more source

Levosimendan is superior to epinephrine on coronary flow for lipid-base resuscitation of bupivacaine-induced asystole in the isolated rat heart

BMC Anesthesiology, 2018
Background Successful resuscitation from asystole induced by bupivacaine requires the reestablishment of a sufficient coronary flow (CF) quickly. This study was designed to test whether levosimendan was superior to epinephrine in the reestablishment of ...
Hongfei Chen, Fangfang Xia, Zhousheng Jin, Kejian Shi, Yun Xia, Le Liu, Thomas J. Papadimos, Xuzhong Xu, Limei Chen   +8 more
doaj   +1 more source

Levosimendan versus dobutamine for sepsis-induced cardiac dysfunction: a systematic review and meta-analysis

Scientific Reports, 2021
Levosimendan and dobutamine are extensively used to treat sepsis-associated cardiovascular failure in ICU. Nevertheless, the role and mechanism of levosimendan in patients with sepsis-induced cardiomyopathy remains unclear.
Dong-Hua Liu, Yi-Le Ning, Yan-Yan Lei, Jing Chen, Yan-Yan Liu, Xin-Feng Lin, Zhong-Qi Yang, Shao-Xiang Xian, Wei-Tao Chen   +8 more
doaj   +1 more source

Anesthetic Management for Pituitary Tumor Resection in a Patient With Acromegalic Cardiomyopathy: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Acromegalic cardiomyopathy is one of the common comorbidities of cardiovascular diseases in patients with acromegaly, and it is also a major risk factor affecting the survival rate of patients with acromegaly. The perioperative management of such patients is a challenge for anesthesiologists.
Shuting Yang, Mi Wang
wiley   +1 more source

Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS/NO pathway: Role for KATP channel [PDF]

, 2017
Aims Although approving new anticonvulsants was a major breakthrough in the field of epilepsy control, so far we have met limited success in almost one third of patients suffering from epilepsy and a definite and reliable method is yet to be found ...
Aleyasin, Ali Reza., Amini-Khoei, Hossein., Amiri, Shayan., Dehpour, Ahmad Reza., Ghasemi, Keyvan., Gooshe, Maziar., Mojahedi, Payam., Tabaeizadeh, Mohammad., Vafaei, Ali., Yousefi, Farbod.   +9 more
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