Results 261 to 270 of about 8,460,931 (324)

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.
Madison M. Reeves, Anna Calliari, Tiffany W. Todd, Candela Maroto Cidfuentes, Karen Jansen‐West, Mei Yue, Yuping Song, Judith Dunmore, Bailey Rawlinson, Erica Engelberg‐Cook, Michael DeTure, Gregory S. Day, Neill R. Graff‐Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Casey N. Cook, Melissa E. Murray, Dennis W. Dickson, Keith A. Josephs, Leonard Petrucelli, Mercedes Prudencio   +21 more
wiley   +1 more source

Depression preceding and following the diagnosis of Parkinson's disease and Lewy body dementia. [PDF]

Gen Psychiatr
Rohde C, Langeskov-Christensen M, Jørgensen LB, Borghammer P, Østergaard SD.   +4 more
europepmc   +1 more source

Brain‐derived plasma p‐tau217 shows enhanced dynamic range for Alzheimer's disease neuropathological change

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Plasma phosphorylated tau (p‐tau), particularly p‐tau217, is a highly specific biomarker of Alzheimer's disease (AD) pathology. However, plasma p‐tau217 can be elevated in rare non‐AD conditions. Brain‐derived (BD) p‐tau217 may reduce these off‐target effects, but its performance against neuropathology has not been evaluated ...
Marisa N. Denkinger, Wagner S. Brum, Antoine Leuzy, Alpana Singh, Taina M. Marques, Valentina Ghisays, Hillary Protas, Yi Su, Ali Atri, Thomas G. Beach, Geidy E. Serrano, Kinal Bhatt, Corey M. Carlson, Katharine Hoffmann, Eric M. Reiman, Nicholas J. Ashton   +15 more
wiley   +1 more source

Tau‐associated neuronal loss in the intermediate nucleus of the human hypothalamus, a putative VLPO analog, in progressive supranuclear palsy and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract BACKGROUND Sleep phenotypes differ in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). The human intermediate nucleus (IntN), a putative ventrolateral preoptic analog, promotes non‐rapid eye movement (NREM) sleep, but its disease‐specific vulnerability is unclear. METHODS Post mortem hypothalami (n = 30; baseline [Braak stage
Shima Rastegar‐Pouyani, Caroline Lew, Felipe L. Pereira, Abhijit Satpati, Ana Moreno Arnas, Vitor Paes, Renata Elaine Paraízo Leite, Claudia Kimie Suemoto, Salvatore Spina, Gowoon Son, Helmut Heinsen, William W. Seeley, Christine M. Walsh, Thomas C. Neylan, Lea T. Grinberg   +14 more
wiley   +1 more source

E326K <i>GBA</i> polymorphism is associated with clinical and pathological features of synucleinopathy in the absence of overt Parkinson's disease or Lewy body dementia. [PDF]

J Parkinsons Dis
Arnold MR, Westaway SK, Woltjer RL, Gray NE, Quinn JF.   +4 more
europepmc   +1 more source

Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION While both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) involve vascular dysfunction, the ocular microvascular differences between them remain largely underinvestigated. METHODS This cross‐sectional study included 650 participants (149 AD, 276 CSVD, and 225 cognitively unimpaired individuals).
Ziyi Zhang, Le Cao, Peng Liu, Shiyun Yang, Yuying Yan, William Robert Kwapong, Ying He, Mingyuan Yang, Hang Wang, Youjie Wang, Zijuan Feng, Jingyu Zhou, Ming Liu, Peng Lei, Bo Wu, Shuting Zhang   +15 more
wiley   +1 more source

Fine-scale individualized gyral folding-based cortical similarity networks reveal distinct organizational patterns in Alzheimer's disease and Lewy body dementia. [PDF]

Imaging Neurosci (Camb)
Chen M, Cao C, Chen T, Alhamad D, Liu T, Su L, Zhu D.   +6 more
europepmc   +1 more source

A pilot study of assessing visual hallucinations using virtual reality in lewy body disorders. [PDF]

Sci Rep
Hirczy SS, Lin YH, Xiong W, Schrift M, Kojima Y.   +4 more
europepmc   +1 more source