Results 101 to 110 of about 56,171 (221)

Sudden Death: An Uncommon Occurrence in Dementia with Lewy Bodies

Journal of Parkinson’s Disease, 2016
We present a 75-year-old woman with dementia and parkinsonism who developed severe orthostatic hypotension and eventually died. Autopsy revealed extensive Lewy body formation in the midbrain, limbic system, intermediate spinal cord, and medulla oblongata.
Joery P. Molenaar, Joyce Wilbers, Marjolein B. Aerts, Quinten H. Leijten, Jan G. van Dijk, Rianne A. Esselink, Bastiaan R. Bloem   +6 more
doaj   +1 more source

Pharmacotherapy of dementia

Journal of Geriatric Mental Health, 2016
This review aims to evaluate the existing evidence for pharmacotherapy for management of dementia. Data search strategies included electronic databases of relevant publications or cross-references.
Ajit Avasthi, Gourav Gupta, Sandeep Grover   +2 more
doaj   +1 more source

Progression of extrapyramidal signs in Alzheimer's disease. clinical and neuropathological correlates [PDF]

, 2015
Extrapyramidal signs (EPS) are frequent in Alzheimer's disease (AD) and core manifestation of related diseases, i.e., dementia with Lewy bodies and Parkinson's disease; furthermore, Lewy bodies and AD-type pathology occur in all three ...
Bruno, Giuseppe, Hawes, Stephen E, Mayeux, Richard, Monsell, Sarah E, Tosto, Giuseppe   +4 more
core   +1 more source

Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment

Movement Disorders, EarlyView.
Abstract Background Autonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown. Objective The aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
A. Enrique Martinez‐Nunez, Kelly A. Mills, Joseph Seemiller, Christopher B. Morrow, Gregory M. Pontone, Abhimanyu Mahajan   +5 more
wiley   +1 more source

Lewy body disease and dementia with Lewy bodies

Proceedings of the Japan Academy, Series B, 2014
In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type.
openaire   +3 more sources

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]

, 2017
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, David, Karen K., Dawson, Ted M., Dewey, Richard B., Jr., Foroud, Tatiana, German, Dwight, Gwinn, Katrina, Huang, Xuemei, Lungu, Codrin, Petyuk, Vlad, Potashkin, Judith A., Rosenthal, Liana S., Saunders-Pullman, Rachel, Scherzer, Clemens R., Sieber, Beth-Anne, St Hillaire-Clarke, Coryse, Sutherland, Margaret, Swanson-Fischer, Christine, Vaillancourt, David E., Walt, David R., West, Andrew B., Zhang, Jing   +25 more
core   +1 more source

Diagnostic Value of Bedside Eye Movement Examination in Movement Disorders

Movement Disorders Clinical Practice, EarlyView.
Eloísa Bittencurt Thomaz de Assis, Paula Martínez Ruiz, Cristina Acosta Gudiel, Hüseyin Nezih Özdemir, Diego Kaski   +4 more
wiley   +1 more source

Quantitative Analysis of Locus Coeruleus Neurons and Thalamic Noradrenergic Axons in a Progressive 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Monkey Model of Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.
Megan Carrillo, Nagore Hernández‐Pinedo, Josefa Zaldivar‐Diez, Isabel Pérez‐Santos, José A. Obeso, Carmen Cavada, Javier Blesa   +6 more
wiley   +1 more source

Imaging breakthroughs in dementia: Pioneering 3D T1-weighted MPRAGE vs. routine spin echo with a focus on Alzheimer's disease [PDF]

Romanian Journal of Neurology
Background. Dementia, a spectrum of neurocognitive disorders, leads to progressive cognitive and functional decline, primarily affecting memory and executive functions.
Vinoth Pandian, Sharmeela S., Nivashini G.R., Karthik Krishna Ramakrishnan, Arunthathy Thangarajah   +4 more
doaj   +1 more source

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

Molecular Neurodegeneration, 2009
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major component of the Lewy body, the mechanisms by which neurons
Perry George, Castellani Rudy J, Takeda Atsushi, Choi Raymond, Kondo Eisaku, Siedlak Sandra L, Chen Shu G, Wang Xinglong, Liu Haihua, Su Bo, Smith Mark A, Zhu Xiongwei, Lee Hyoung-gon   +12 more
doaj   +1 more source