Results 121 to 130 of about 32,200 (252)

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

An Ecological and Processual Understanding of Family Resilience in Dementia: A Qualitative Meta‐Synthesis

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore how family resilience emerges and unfolds in dementia. Design Qualitative meta‐synthesis using thematic synthesis. Data Sources PubMed, CINAHL, Web of Science, PsycINFO were searched from inception through August 26, 2025. Methods Studies examining family‐level resilience, adaptation or coping in home‐based dementia care using ...
Yoosun Yang, Jun‐Ah Song
wiley   +1 more source

Cutaneous Phosphorylated Alpha-Synuclein in Lewy Body Dementia. [PDF]

Ann Clin Transl Neurol
Gibbons CH, Levine T, Adler CH, Bellaire B, Wang N, Agarwal P, Aldridge GM, Barboi A, Claassen D, Evidente VGH, Galasko D, Gonzalez-Duarte A, Gil R, Gudesblatt M, Isaacson SH, Kaufmann H, Khemani P, Kumar R, Lamotte G, Liu AJ, McFarland NR, Miglis MG, Reynolds A, Sahagian GA, Saint-Hilaire MH, Schwartzbard JB, Singer W, Soileau MJ, Vernino S, Millar Vernetti P, Yerstein O, Freeman R.   +31 more
europepmc   +1 more source

Exploring Theory of Mind abilities in patients with probable idiopathic normal pressure hydrocephalus

Journal of Neuropsychology, EarlyView.
Abstract This study investigated Theory of Mind (ToM) deficits in patients with suspected idiopathic normal pressure hydrocephalus (iNPH), a condition affecting motor, cognitive and autonomic functions. Given the overlap between ToM‐related neural networks and those affected in iNPH, we examined whether ToM impairments are a feature of the disease ...
Akrivi Vatsi, George Stranjalis, Stylianos Gkatzonis, Christos Koutsarnakis, Eleftherios Neromyliotis, Aristotelis Kalyvas, Ion N. Beratis, Evangelos Drosos, Spyridon Komaitis, Evangelia Liouta   +9 more
wiley   +1 more source

The utility of a composite endpoint for tracking disease progression in Lewy body dementia. [PDF]

Alzheimers Dement (N Y)
Matar E, White SR, Taylor JP, Thomas A, McKeith I, Kane J, Lewis S, Surendranathan A, O'Brien J.   +8 more
europepmc   +1 more source

Associations between apathy and global cognition in a 5‐year follow‐up of individuals with Alzheimer's disease

Journal of Neuropsychology, EarlyView.
Abstract Apathy is a common neuropsychiatric symptom in Alzheimer's disease (AD) associated with cognitive and functional impairment. Longitudinal studies have examined the associations between apathy and cognition in AD and other dementias, but more information is needed to understand whether the relationships are consistent longitudinally, and ...
Henna‐Riikka Loukola, Maikki Kärkkäinen, Tuomas Selander, Kirsi Honkalampi, Anne M. Koivisto, Toni T. Saari   +5 more
wiley   +1 more source

Spatially resolved molecular signatures of Lewy body dementia. [PDF]

Acta Neuropathol
Jin Y, Chen K, Wixom AQ, Li Z, Koga S, Sekiya H, Xhafkollari G, Castanedes-Casey M, Santhakumar H, Meneses AD, Neff AJ, Bu G, Heckman MG, Liu Y, Ross OA, Dickson DW, Zhao N.   +16 more
europepmc   +1 more source

Interventions to Reduce Loneliness in Informal Caregivers of People With Dementia: A Systematic Review

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To summarize the current evidence on reducing loneliness among informal caregivers of people with dementia, such as family members or friends. Design A systematic review. Methods The methodological quality was evaluated using the revised Cochrane risk‐of‐bias tool for randomized controlled trials and the revised JBI critical appraisal ...
Tianxue Hou, Yuqian Luo, Mu‐Hsing Ho, Xiaohang Liu, Yuelin Li, Chia‐Chin Lin   +5 more
wiley   +1 more source

Brain pathology in relation to somatic diseases: Exploring the body–brain crosstalk

Journal of Internal Medicine, EarlyView.
Abstract Several somatic diseases have been consistently linked with an increased dementia risk. However, the underlying neuropathological substrates remain poorly characterized. This narrative review aims to summarize evidence on the association between common age‐related somatic conditions (i.e., heart diseases, type 2 diabetes, kidney disease, liver
G. Grande, M. Valletta, F. Gasparini, D. L. Vetrano, M. Canevelli, J. R. Bacci, C. Qiu, A. Marengoni, M. Toccaceli Blasi, H. Xu, L. Fratiglioni, M. M. Mielke   +11 more
wiley   +1 more source