Results 171 to 180 of about 56,147 (276)
Apolipoprotein E and Alzheimer’s disease: The influence of apolipoprotein E on amyloid- and other amyloidogenic proteins [PDF]
Agosta +207 more
core +2 more sources
Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet +12 more
wiley +1 more source
APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology
Abstract INTRODUCTION The apolipoprotein E ε4 (APOE ε4) allele is a major genetic risk factor for Alzheimer's disease, but its relevance to cognition in intracranial atherosclerosis (ICAS) remains unclear. We investigated the association between APOE ε4 and cognition in ICAS. METHODS Baseline data from a multicenter cohort were analyzed.
Anqi Cheng +14 more
wiley +1 more source
Association between brain volume and depression in Alzheimer's disease: Neuroimaging insights
Abstract INTRODUCTION Alzheimer's disease (AD) often co‐occurs with depression, affecting cognitive function and quality of life. Understanding the neurobiological links between brain abnormalities and depressive symptoms is essential for effective treatment.
Chao Tang +6 more
wiley +1 more source
Intrinsic capacity in Lewy body dementia: a review. [PDF]
Sanapo F +3 more
europepmc +1 more source
Greater locus coeruleus vulnerability in atypical clinicopathologic forms of Alzheimer's disease
Abstract INTRODUCTION The locus coeruleus (LC) degenerates early in Alzheimer's disease (AD). However, the extent of rostrocaudal degeneration across clinicopathologic heterogeneity remains underexplored in AD. METHODS Using digital pathology, we quantified LC neuronal density and area at three neuroanatomic levels in a large AD series.
Sara Rose Dunlop +16 more
wiley +1 more source
Loxapine for the treatment of psychosis in Lewy body dementia: A case report. [PDF]
Wu L, Jhawar A.
europepmc +1 more source
Abstract INTRODUCTION The medial prefrontal cortex (mPFC) is critical for executive function, behavioral inhibition, and memory. Its high vulnerability to dementia, compared to other prefrontal regions, remains unclear. METHODS We analyzed post mortem brain tissue from 118 older subjects, including post‐stroke survivors, Alzheimer's disease; vascular ...
Dan D. Jobson +6 more
wiley +1 more source
Lewy body dementia promotion by air pollutants. [PDF]
Zhang X +42 more
europepmc +1 more source
Abstract Alzheimer's disease and related dementias (ADRD) affects millions of patients worldwide and is a leading cause of morbidity in older adults. Patients with ADRD are particularly susceptible to developing urinary tract infection (UTI) and UTI‐related delirium, creating a self‐perpetuating cycle in which ADRD increases vulnerability to infection ...
Sarah Kim +3 more
wiley +1 more source

