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Environmental Pollution, 2020
N6-methyladenosine (m6A) modification, the most prevalent form of RNA methylation, modulates gene expression post-transcriptionally. Di-(2-ethylhexyl) phthalate (DEHP) is a common environmental endocrine disrupting chemical that induces testicular injury
T. Zhao +9 more
semanticscholar +1 more source
N6-methyladenosine (m6A) modification, the most prevalent form of RNA methylation, modulates gene expression post-transcriptionally. Di-(2-ethylhexyl) phthalate (DEHP) is a common environmental endocrine disrupting chemical that induces testicular injury
T. Zhao +9 more
semanticscholar +1 more source
Age-related changes in human Leydig cell status.
Human Reproduction, 2020STUDY QUESTION What are the consequences of ageing on human Leydig cell number and hormonal function? SUMMARY ANSWER Leydig cell number significantly decreases in parallel with INSL3 expression and Sertoli cell number in aged men, yet the in vitro ...
Valentina Mularoni +14 more
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Effects of perfluorooctanoic acid on stem Leydig cell functions in the rat.
Environmental Pollution, 2019Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic (PFOS) are two perfluorinated chemical products widely existing in the environment. Evidence suggested that PFOA might relate to male reproductive dysfunction in rats and humans.
Hemin Lu +8 more
semanticscholar +1 more source
1983
The role of the testis in the development of masculine features has been known for literally thousands of years. It is, however, only within the past 150 years that we have begun to understand how the testes have these effects. The location and appearances of the cells that now bear his name were first described by Von Leydig in 1857.
Y, Hodgson, B, Hudson
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The role of the testis in the development of masculine features has been known for literally thousands of years. It is, however, only within the past 150 years that we have begun to understand how the testes have these effects. The location and appearances of the cells that now bear his name were first described by Von Leydig in 1857.
Y, Hodgson, B, Hudson
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2018
Leydig cells (LC) are present in the testicular interstitial tissue, and their main function is to produce testosterone (T) for the maintenance of spermatogenesis and extratesticular androgenic and anabolic functions. LC appear in fetal life, and their hormonal products (T and INSL3) direct male fetal masculinization and early development of genital ...
Huhtaniemi, I., Teerds, K.J.
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Leydig cells (LC) are present in the testicular interstitial tissue, and their main function is to produce testosterone (T) for the maintenance of spermatogenesis and extratesticular androgenic and anabolic functions. LC appear in fetal life, and their hormonal products (T and INSL3) direct male fetal masculinization and early development of genital ...
Huhtaniemi, I., Teerds, K.J.
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Congenital Leydig cell hyperplasia
Histopathology, 1988The testes and epididymes collected at autopsy from 21 newborns showed apparent Leydig cell hyperplasia which was studied by light and electron microscopy. Twelve newborns were the sons of diabetic mothers, two had undergone rhesus isoimmunization, two were twins of a non‐diabetic mother, three had Beckwitz‐Widemann's syndrome, and two had ...
M, Nistal +2 more
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Archives of Andrology, 1986
The ultrastructure of Leydig cell hyperplasia is described. The hyperplastic Leydig cells differ morphologically from normal Leydig cells as well as from Leydig tumor cells. They have less smooth endoplasmic reticulum and less lipofuscin pigment in their cytoplasm, and the nuclear membrane shows more irregular indentations than normal Leydig cells.
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The ultrastructure of Leydig cell hyperplasia is described. The hyperplastic Leydig cells differ morphologically from normal Leydig cells as well as from Leydig tumor cells. They have less smooth endoplasmic reticulum and less lipofuscin pigment in their cytoplasm, and the nuclear membrane shows more irregular indentations than normal Leydig cells.
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Archives of Gynecology and Obstetrics, 2001
Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign, and almost all are localised unilaterally. Herewith, we describe an ovarian Sertoli-Leydig cell tumor in an 11-year-old girl.
T, Lantzsch +5 more
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Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign, and almost all are localised unilaterally. Herewith, we describe an ovarian Sertoli-Leydig cell tumor in an 11-year-old girl.
T, Lantzsch +5 more
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INSL3 Expression in Leydig Cell Hyperplasia and Leydig Cell Tumors
Applied Immunohistochemistry & Molecular Morphology, 2019Insulin-like 3 (INSL3) is a hormone produced by Leydig cells (LCs) and leads to physiological testicular descent during embryonic development. We investigated the expression of INSL3 by immunohistochemistry in normal LCs, in Leydig cell tumor (LCT) (n=17 including 15 testes and 2 ovaries) and in Leydig cell hyperplasia (LCH) (n=10).
Nelli S, Lakis +5 more
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Malignant Feminizing Leydig Cell Tumor
Journal of Urology, 1984AbstractA patient with a feminizing malignant Leydig cell tumor is presented. Hormonal assays revealed increased production of prolactin, estradial, and total estrogens. Eleven years after the onset of his disease he remains clinically well.
C M, Shapiro, A, Sankovitch, W J, Yoon
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