Journal of Agricultural and Food Chemistry, 2019 As a plasticizer, di(2-ethylhexyl) phthalate (DEHP) is the most usually used phthalates. Leydig cell is a male-specific cell, which plays a principal role in spermatogenesis and masculinization by androgens of synthesis and secretion.
Yi Zhao +6 more
semanticscholar +1 more source
Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes [PDF]
, 2016 Aged testes undergo profound histological and morphological alterations leading to a reduced functionality. Here, we investigated whether variations in longevity affect the development of local inflammatory processes, the oxidative state and the ...
Bartke, Andrzej +7 more
core +2 more sources
Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells [PDF]
Development, 2018 ABSTRACT Previous studies have established that fetal Leydig cells (FLCs) and adult Leydig cells (ALCs) show distinct functional characteristics. However, the lineage relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal ...
Yuichi Shima +7 more
openaire +2 more sources
Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice
Reproductive Biology and Endocrinology, 2003 During mammalian testis development distinct generations of fetal and adult Leydig cells arise. Luteinising hormone (LH) is required for normal adult Leydig cell function and for the establishment of normal adult Leydig cell number but its role in the ...
Charlton HM +4 more
doaj +1 more source
Biology of Reproduction, 2019 In mammals, circadian clock regulates concentration of many reproductive hormones including testosterone. Previously, we characterized pattern of circadian transcription of core clock genes in testosterone-producing Leydig cells. Here, the potential role
Aleksandar Z Baburski +2 more
semanticscholar +1 more source
Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis [PDF]
, 2008 Publisher ...
Claessens, Frank +7 more
core +1 more source
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells
Frontiers in Physiology, 2017 Adult Leydig cells (ALCs) are the steroidogenic cells in the testes that produce testosterone. ALCs develop postnatally from a pool of stem cells, referred to as stem Leydig cells (SLCs). SLCs are spindle-shaped cells that lack steroidogenic cell markers,
Leping Ye +4 more
semanticscholar +1 more source
Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae) [PDF]
, 2018 Teleostei present great plasticity regarding sex change. During sex reversal, the whole gonadincluding the germinal epithelium undergoes significant changes, remodeling, and neoformation.However, there is no information on the changes that occur within ...
Antoneli, Fernanda +3 more
core +2 more sources
Aldosterone Blocks Rat Stem Leydig Cell Development In Vitro
Frontiers in Endocrinology, 2018 Aldosterone (ALDO) is a primary endogenous mineralocorticoid, appearing as the main hormone controlling sodium and water homeostasis. Its emerging role in the development of many organs has gained interest over the past few years.
Jingwei Zhang +9 more
doaj +1 more source
Regulation of 3β-Hydroxysteroid Dehydrogenase/∆5-∆4 Isomerase: A Review [PDF]
, 2013 This review focuses on the expression and regulation of 3β-hydroxysteroi ddehydrogenase/Δ5-Δ4 isomerase (3β-HSD), with emphasis on the porcine version. 3β-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids ...
Abbaszade +121 more
core +2 more sources