Results 91 to 100 of about 16,604,758 (298)
Journal of Applied Toxicology, EarlyView.ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan +3 more
wiley +1 more source
Effect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells [PDF]
, 1993 Oxytocin and its receptor are found in the corpus luteum in a variety of species, including the human. In the present study we used fura-2 microfluorimetry to investigate whether activation of the oxytocin receptor of cultured human granulosa-lutein ...
Wiemann, M. +4 more
core +1 more source
Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility
Journal of Applied Toxicology, EarlyView.ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues +3 more
wiley +1 more source
THE EFFECTS OF VITAMIN C ON GLYCIDAMIDE-INDUCED CELLULAR DAMAGE AND APOPTOSIS IN MOUSE LEYDIG CELLS
Trakya University Journal of Natural Sciences, 2019 The aim of this study was to elucidate the role of vitamin C on glycidamide-induced cytotoxicity, oxidative damage and cell death in Leydig (TM3) cells.
Banu Orta Yılmaz
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Mining plays a crucial role in economic development, but improper management can lead to severe environmental degradation. Particularly for iron ore, mining generates vast amounts of tailings often stored in unstable dams. This study aims to investigate the toxicological impacts of environmentally relevant concentrations of metals mixture ...
Kalinka Helóra Gomes de Almeida +7 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, 2017 This study investigated the relationship between germ and Leydig cell death, testosterone, and adiponectin levels in cadmium-mediated acute toxicity. Cadmium chloride was administered in a single dose to five groups of rats: G1 (0.9% NaCl) and G2 to G5 ...
M. C. Cupertino +6 more
semanticscholar +1 more source
UroPrecision, EarlyView.Abstract Background Viral infections have been identified as potential disruptors of male reproductive health. This study aimed to investigate the prevalence of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV‐6), and herpes simplex virus types 1 and 2 (HSV‐1/2) DNA in semen samples from fertile and infertile men within the potential impact of ...
Seyedeh Zahra Hashemi +7 more
wiley +1 more source
Communications BiologyExposure of testes to high-temperature environment results in defective spermatogenesis. Zebrafish exposed to high temperature exhibited apoptosis not only in germ cells but also in Leydig cells, as expected from studies using mice or salmon.
Yasuhiro Yamamoto +2 more
doaj +1 more source
Wildlife Biology, EarlyView.After decades of dramatic reductions in their populations, Italian wolves have begun recolonizing parts of their historic range. This growth in populations can lead to potential conflicts with human activities, which remain the main cause of wolf mortality.
Ilaria Troisio +8 more
wiley +1 more source
Insulin-like factor 3 (INSL3) and the HPG axis in the male
Frontiers in Endocrinology, 2014 The HPG (hypothalamo-pituitary-gonadal) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation.
Richard eIvell +3 more
doaj +1 more source