Results 81 to 90 of about 16,604,758 (298)

Hormonal control and signaling of the testis of the bat Molossus molossus during the processes of testicular maturation, regression, and recrudescence

The Anatomical Record, EarlyView.
Abstract Molossus molossus, a species of neotropical bat belonging to the Molossidae family, has an annual reproductive cycle that includes two peaks of spermatogenic activity, one in April and another in September, and a period of total testicular regression in December.
Emília M. Soares, Juliana F. Ferraz, Cornélio S. Santiago, Larissa P. R. Venâncio, Arlindo G. Macedo‐Junior, Sebastião R. Taboga, Mateus R. Beguelini   +6 more
wiley   +1 more source

Metabolic Coupling Determines the Activity: Comparison of 11β-Hydroxysteroid Dehydrogenase 1 and Its Coupling between Liver Parenchymal Cells and Testicular Leydig Cells. [PDF]

PLoS ONE, 2015
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) interconverts active 11β-hydroxyl glucocorticoids and inactive 11keto forms. However, its directionality is determined by availability of NADP+/NADPH.
Xingwang Li, Guoxin Hu, Xiaoheng Li, Yi-Yan Wang, Yuan-Yuan Hu, Hongyu Zhou, Syed A Latif, David J Morris, Yanhui Chu, Zhiqiang Zheng, Ren-Shan Ge   +10 more
doaj   +1 more source

Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells

Cell Death and Disease, 2018
Diabetes mellitus affects a large number of men of reproductive age and it usually leads to serious reproductive disorders. However, the underlying mechanisms and specific therapies still remain largely unknown. We observed Leydig cell loss in the testes
Z. Du, Shuanshuan Xu, Shu-Xian Hu, Hong Yang, Zhe Zhou, K. Sidhu, Yiliang Miao, Zhong-Hua Liu, W. Shen, R. Reiter, J. Hua, S. Peng   +11 more
semanticscholar   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

NR2F2 regulation of interstitial cell fate in the embryonic mouse testis and its impact on differences of sex development

Nature Communications
Testicular fetal Leydig cells produce androgens essential for male reproductive development. Impaired fetal Leydig cell differentiation leads to differences of sex development including hypospadias, cryptorchidism, and infertility.
Martín Andrés Estermann, Sara A. Grimm, Abigail S. Kitakule, Karina F. Rodriguez, Paula R. Brown, Kathryn McClelland, Ciro M. Amato, Humphrey Hung-Chang Yao   +7 more
doaj   +1 more source

TGF-β1 regulation of estrogen production in mature rat Leydig cells. [PDF]

PLoS ONE, 2013
BACKGROUND: Besides androgens, estrogens produced in Leydig cells are also crucial for mammalian germ cell differentiation. Transforming growth factor-β1 (TGF-β1) is now known to have multiple effects on regulation of Leydig cell function.
Man-Li Liu, Huan Wang, Zong-Ren Wang, Yu-Fen Zhang, Yan-Qiu Chen, Fang-Hong Zhu, Yuan-Qiang Zhang, Jing Ma, Zhen Li   +8 more
doaj   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Foetal Leydig Cells and the Neuroendocrine System [PDF]

, 2008
It has been shown that adult human Leydig cells express a number of neuroendocrine markers, and, therefore, could be considered as a part of the neuroendocrine system in the adult. A limited number of studies have dealt with the dynamics of development
Kos, Marina, Šklebar, Ivan, Ježek, Davor, Šemanjski, Kristina, Šklebar, Duška   +4 more
core   +3 more sources

Protective Effects of Fenugreek and Stevia Extracts on Dexamethasone‐Induced Testicular Damage in a Rat Model

Food Safety and Health, EarlyView.
Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad, Medhat Ibrahim A. Omar, Mohammed I. Elkhateeb, Ahmed A. Zaky   +3 more
wiley   +1 more source

Mouse leydig cells with different androgen production potential are resistant to estrogenic stimuli but responsive to bisphenol a which attenuates testosterone metabolism.

PLoS ONE, 2013
It is well known that estrogens and estrogen-like endocrine disruptors can suppress steroidogenic gene expression, attenuate androgen production and decrease differentiation of adult Leydig cell lineage.
Iuliia Savchuk, Olle Söder, Konstantin Svechnikov   +2 more
doaj   +1 more source