Circulating LH/hCG receptor (LHCGR) may identify pre-treatment IVF patients at risk of OHSS and poor implantation [PDF]
Reproductive Biology and Endocrinology, 2011 Background Successful pregnancy via in vitro fertilization (IVF) depends on the recovery of an adequate number of healthy oocytes and on blastocyst implantation following uterine transfer. Two hormones, LH and hCG, utilize a common LH/hCG receptor (LHCGR)
Chambers Anne E +4 more
doaj +2 more sources
A novel variant luteinizing hormone receptor in the first transmembrane helix of two homozygous Iranian patients: case report [PDF]
Egyptian Journal of Medical Human Genetics, 2022 Background Leydig cell hypoplasia (LCH) is a rare autosomal recessive endocrine syndrome that affects the normal development of male external genitalia in 46, XY individuals and is one of the causes of disorder of sexual differentiation (DSD) in males ...
Samaneh Sharif +6 more
doaj +10 more sources
Urology Case Reports, 2022 Leydig cell hypoplasia is a rare autosomal recessive condition caused by mutations in luteinizing hormone/chorionic gonadotropin receptor (LHCGR) genes in which 46, XY patients demonstrate a wide spectrum of disorders/differences of sex development (DSD)
Kiarad Fendereski +5 more
doaj +2 more sources
Widespread Distribution of Luteinizing Hormone/Choriogonadotropin Receptor in Human Juvenile Angiofibroma: Implications for a Sex-Specific Nasal Tumor [PDF]
CellsJuvenile angiofibroma (JA) is a rare, sex-specific, and highly vascularized nasal tumor that almost exclusively affects male adolescents, but its etiology has been controversial.
Silke Wemmert +6 more
doaj +2 more sources
Prevalence and genetic etiology of poly-cystic ovarian syndrome (PCOS) in Mauritania [PDF]
Frontiers in Reproductive HealthBackgroundPolycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder characterized by polycystic ovaries, oligoanovulation, hyperandrogenism and infertility.
Marieme Elwafi +8 more
doaj +2 more sources
Quantitative ELISAs for serum soluble LHCGR and hCG-LHCGR complex: potential diagnostics in first trimester pregnancy screening for stillbirth, Down’s syndrome, preterm delivery and preeclampsia [PDF]
Reproductive Biology and Endocrinology, 2012 Background Soluble LH/hCG receptor (sLHCGR) released from placental explants and transfected cells can be detected in sera from pregnant women. To determine whether sLHCGR has diagnostic potential, quantitative ELISAs were developed and tested to examine
Chambers Anne E +7 more
doaj +5 more sources
Expression of LHCGR in Pheochromocytomas Unveils an Endocrine Mechanism Connecting Pregnancy and Epinephrine Overproduction [PDF]
Hypertension, 2022 Background: The mechanisms by which pregnancy may unmask pheochromocytomas and paragangliomas are not totally understood. We hypothesized that gestational hormones may participate in the pathophysiology of catecholamine excess during pregnancy.
Antoine-Guy Lopez +11 more
openalex +5 more sources
Lhcgr Expression in Granulosa Cells: Roles for PKA-Phosphorylated β-Catenin, TCF3, and FOXO1 [PDF]
Molecular Endocrinology, 2013 Ovarian follicles lacking FSH or FSH receptors fail to progress to a preovulatory stage, resulting in infertility. One hallmark of the preovulatory follicle is the presence of luteinizing hormone/choriogonadotropin receptors (LHCGR) on granulosa cells (GCs). However, the mechanisms by which FSH induces Lhcgr gene expression are poorly understood.
Nathan C. Law +4 more
openalex +6 more sources