Differences in signal activation by LH and hCG are mediated by the LH/CG receptor`s extracellular hinge region [PDF]
Frontiers in Endocrinology, 2015 The human lutropin/choriogonadotropin receptor (LHCGR) can be activated by binding two slightly different gonadotropic glycoprotein hormones, choriogonadotropin (CG) - secreted by the placenta, and lutropin (LH) - produced by the pituitary.
Paul eGrzesik +8 more
doaj +4 more sources
International Journal of Reproductive BioMedicineBackground: Follicle-stimulating hormone receptor (FSHR) and luteinizing hormone/choriogonadotropin receptor (LHCGR) are integral to ovarian function, facilitating follicle development and maturation through their respective hormonal interactions.
Jayesh Amin +6 more
doaj +2 more sources
Circulating LH/hCG receptor (LHCGR) may identify pre-treatment IVF patients at risk of OHSS and poor implantation [PDF]
Reproductive Biology and Endocrinology, 2011 Background Successful pregnancy via in vitro fertilization (IVF) depends on the recovery of an adequate number of healthy oocytes and on blastocyst implantation following uterine transfer. Two hormones, LH and hCG, utilize a common LH/hCG receptor (LHCGR)
Chambers Anne E +4 more
doaj +2 more sources
Análise da expressão dos receptores do peptídeo insulinotrópico dependente de glicose (GIPR) e do hormônio luteinizante (LHCGR) nas hiperplasias adrenocorticais humanas [PDF]
, 2009 OBJECTIVE: To analyze the aberrant expression of the GIPR and LHCGR in different forms of adrenocortical hyperplasia: ACTH-independent macronodular adrenal hyperplasia (AIMAH), primary pigmented nodular adrenocortical disease (PPNAD) and diffuse adrenal ...
COSTA, Marcia Helena Soares +7 more
core +3 more sources
A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration [PDF]
Scientific Reports, 2017 Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide ...
Kyoko Kawashima-Kumagai +24 more
doaj +2 more sources
Prevalence and genetic etiology of poly-cystic ovarian syndrome (PCOS) in Mauritania [PDF]
Frontiers in Reproductive HealthBackgroundPolycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder characterized by polycystic ovaries, oligoanovulation, hyperandrogenism and infertility.
Marieme Elwafi +8 more
doaj +2 more sources
Widespread Distribution of Luteinizing Hormone/Choriogonadotropin Receptor in Human Juvenile Angiofibroma: Implications for a Sex-Specific Nasal Tumor [PDF]
CellsJuvenile angiofibroma (JA) is a rare, sex-specific, and highly vascularized nasal tumor that almost exclusively affects male adolescents, but its etiology has been controversial.
Silke Wemmert +6 more
doaj +2 more sources
Quantitative ELISAs for serum soluble LHCGR and hCG-LHCGR complex: potential diagnostics in first trimester pregnancy screening for stillbirth, Down’s syndrome, preterm delivery and preeclampsia [PDF]
Reproductive Biology and Endocrinology, 2012 Background Soluble LH/hCG receptor (sLHCGR) released from placental explants and transfected cells can be detected in sera from pregnant women. To determine whether sLHCGR has diagnostic potential, quantitative ELISAs were developed and tested to examine
Chambers Anne E +7 more
doaj +4 more sources