Results 11 to 20 of about 12,270 (235)

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis [PDF]

Frontiers in Endocrinology, 2022
An association between endometriosis and luteinized unruptured follicle syndrome (LUFs) has long been identified. Although inactivating mutation of luteinizing hormone/choriogonadotropin receptor (LHGCR) results in LUFs, whether LHCGR contributes to ...
Ting Geng, Ting Geng, Ting Geng, Yifan Sun, Yifan Sun, Yifan Sun, Lin Cheng, Lin Cheng, Lin Cheng, Yuming Cao, Yuming Cao, Yuming Cao, Ming Zhang, Ming Zhang, Zhidan Hong, Zhidan Hong, Ling Ma, Ling Ma, Yuanzhen Zhang, Yuanzhen Zhang, Yuanzhen Zhang   +20 more
doaj   +4 more sources

LHCGR inactivating variants: single center experience and systematic review of phenotype-genotype of 46,XY and 46,XX patients [PDF]

Endocrine Connections
Background: The data on Leydig cell hypoplasia (LCH) resulting from biallelic Luteinizing hormone/chorionic gonadotropin receptor (LHCGR) inactivating variants is limited to case series.
Rohit Barnabas, Swati Jadhav, Anurag Ranjan Lila, Sirisha Kusuma Boddu, Saba Samad Memon, Sneha Arya, Samiksha Chandrashekhar Hegishte, Manjiri Karlekar, Virendra A Patil, Vijaya Sarathi, Nalini S Shah, Tushar Bandgar   +11 more
doaj   +3 more sources

Genetic models for the study of luteinizing hormone receptor function [PDF]

Frontiers in Endocrinology, 2015
The luteinizing hormone/chorionic gonadotropin receptor, LHCGR, is essential for fertility in men and women. LHCGR binds luteinizing hormone (LH) as well as the highly homologous chorionic gonadotropin (CG).
Prema eNarayan
doaj   +4 more sources

Microvesicle-mediated release of soluble LH/hCG receptor (LHCGR) from transfected cells and placenta explants [PDF]

Reproductive Biology and Endocrinology, 2011
Placental hCG and pitutary LH transduce signals in target tissues through a common receptor (LHCGR). We demonstrate that recombinant LHCGR proteins which include the hormone-binding domain are secreted from transfected cells and that natural LHCGR is ...
Randeva Harpal, Stanley Paul F, Chambers Anne E, Banerjee Subhasis   +3 more
doaj   +2 more sources

A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration [PDF]

Scientific Reports, 2017
Bilateral neovascular age-related macular degeneration (AMD) causes much more handicaps for patients than unilateral neovascular AMD. Although several AMD-susceptibility genes have been evaluated for their associations to bilaterality, genome-wide ...
Kyoko Kawashima-Kumagai, Kenji Yamashiro, Munemitsu Yoshikawa, Masahiro Miyake, Gemmy Cheung Chui Ming, Qiao Fan, Jia Yu Koh, Masaaki Saito, Masako Sugahara-Kuroda, Maho Oishi, Yumiko Akagi-Kurashige, Isao Nakata, Hideo Nakanishi, Norimoto Gotoh, Akio Oishi, Hiroshi Tamura, Sotaro Ooto, Akitaka Tsujikawa, Yasuo Kurimoto, Tetsuju Sekiryu, Fumihiko Matsuda, Chiea-Chuen Khor, Ching-Yu Cheng, Tien Yin Wong, Nagahisa Yoshimura   +24 more
doaj   +2 more sources

46 XY undervirulized male DSD: Reporting a patient with prenatally diagnosed disorder/difference of sex development (DSD) with heterozygous LHCGR mutations

Urology Case Reports, 2022
Leydig cell hypoplasia is a rare autosomal recessive condition caused by mutations in luteinizing hormone/chorionic gonadotropin receptor (LHCGR) genes in which 46, XY patients demonstrate a wide spectrum of disorders/differences of sex development (DSD)
Kiarad Fendereski, John Carey, Kathleen Timme, Katherine Hayes, Jessica Robnett, Anthony Schaeffer   +5 more
doaj   +2 more sources

Familial male-limited precocious puberty due to an activating mutation of the LHCGR: a case report and literature review [PDF]

Annals of Pediatric Endocrinology & Metabolism
Familial male-limited precocious puberty (FMPP) is a rare form of gonadotropin-independent precocious puberty that is caused by an activating mutation of the LHCGR gene.
Jihyun Ha, Yunha Choi,, Mo Kyung Jung, Eun-Gyong Yoo, Han-Wook Yoo   +4 more
doaj   +3 more sources

Role of Single Nucleotide Variants in FSHR, GNRHR, ESR2 and LHCGR Genes in Adolescents with Polycystic Ovary Syndrome [PDF]

Diagnostics, 2021
Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women, affecting up to 16.6% of reproductive-age women. PCOS symptoms in adolescents comprise oligomenorrhoea/amenorrhoea and biochemical and/or clinical hyperandrogenism ...
Lasma Lidaka, Laine Bekere, Adele Rota, Jekaterina Isakova, Gunta Lazdane, Anda Kivite-Urtane, Iveta Dzivite-Krisane, Inga Kempa, Zane Dobele, Linda Gailite   +9 more
doaj   +2 more sources

A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies [PDF]

Reproductive Biology and Endocrinology, 2005
Human chorionic gonadotrophin (hCG) is released from placental trophoblasts and is involved in establishing pregnancy by maintaining progesterone secretion from the corpus luteum. Serum hCG is detected in the maternal circulation within the first 2–3 wks
Spencer Kevin, Loosfelt Hugues, Papageorghiou Aris, Chambers Anne E, Smallwood Alan, Banerjee Subhasis, Campbell Stuart, Nicolaides Kypros   +7 more
doaj   +2 more sources

Genetic variants (Lhcgr W495X/+) and environmental toxicants (DEHP) synergistically induce DSD by interfering with steroidogenic gene expression [PDF]

Biology of Sex Differences
Background Emerging evidence suggests that genetic variants and environmental toxicants may synergistically contribute to DSD. To test this hypothesis, we employed Lhcgr W495X/+ (luteinizing hormone/chorionic gonadotropin receptor) male mice subjected to
Xie Qigen, Xia Kai, Cao Haiming, Xu Zhe, Gao Yong, Deng Chunhua   +5 more
doaj   +2 more sources