Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study. [PDF]
Reprod Biol EndocrinolMa W +14 more
europepmc +2 more sources
A delayed ovulation of Progestin-Primed Ovarian Stimulation (PPOS) by down-regulating the LHCGR/PGR pathway [PDF]
iScience, 2022 Abstract PPOS as a new clinic ovulation stimulation protocol, its role in ovulation and regulatory mechanism is not clear. The clinical PPOS protocol was simulated in mice, and it had a delayed ovulation than the control group at 12.5 hours after hCG trigger.
Yating Xie +8 more
openalex +4 more sources
Leydig cell hypoplasia type 1 diagnosed in early childhood with inactivating mutation in LHCGR gene [PDF]
Oxford Medical Case Reports, 2021 ABSTRACT Leydig cell aplasia/hypoplasia is an autosomal recessive condition. In its complete form, these patients are 46XY but are cryptorchid and phenotypically female. Most cases reported in literature presented with in adolescence with pubertal delay.
Fatma Özgüç Çömlek +3 more
openalex +5 more sources
MeCP2 duplication causes hyperandrogenism by upregulating LHCGR and downregulating RORα [PDF]
Cell Death & Disease, 2021 AbstractDuplication of MECP2 (methyl-CpG-binding protein 2) gene causes a serious neurological and developmental disorder called MECP2 duplication syndrome (MDS), which is usually found in males. A previous clinical study reported that MDS patient has precocious puberty with hyperandrogenism, suggesting increased MeCP2 may cause male hyperandrogenism ...
Yu Wu +4 more
openaire +4 more sources
Evaluating the impact of LHCGR gene polymorphism on polycystic ovary syndrome: a comprehensive meta-analysis and power assessment. [PDF]
J Turk Ger Gynecol AssocThomas SM, Veerabathiran R.
europepmc +2 more sources
Pregnancy and Live Birth In Women With Pathogenic LHCGR Variants Using Their Own Oocytes [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2019 Abstract Context The LH/chorionic gonadotropin receptor (LHCGR) is mainly expressed in gonads and plays important roles in estradiol production, ovulation, and luteal formation. Women with pathogenic LHCGR variants suffer from infertility, and successful fertility treatments for such women have never ...
Xuefeng Lu +16 more
openalex +3 more sources
A case of micropenis caused by compound heterozygote mutations in luteinizing hormone/choriogonadotropin receptor (LHCGR) [PDF]
Jichu yixue yu linchuang, 2022 Objective To investigate the pathogenic gene mutations and clinical characteristics in a patient with compound heterozygote gene mutations in luteinizing hormone/choriogonadotropin receptor (LHCGR) gene.
YANG Yu-fan, ZHAO Ya-ling, WANG Xi, NIE Min, WU Xue-yan, MAO Jiang-feng
doaj +1 more source
Акушерство, гинекология и репродукция, 2023 Introduction. Infertility is a highly fatal reproductive system disorder that affects the ability of a couple to reproduce. Over the past decades, a drastic uplift has been recorded in infertility cases among males ranging from 20 to 70 % indicating ...
N. A. Oohayyed +5 more
doaj +1 more source
Evidence for gating roles of protein kinase A and protein kinase C in estradiol-induced luteinizing hormone receptor (lhcgr) expression in zebrafish ovarian follicle cells. [PDF]
PLoS ONE, 2013 Estradiol (E2) stimulates luteinizing hormone receptor (lhcgr) expression in zebrafish follicle cells via nuclear estrogen receptors (nERs) that are likely expressed on the membrane, and lhcgr responds to E2 in a biphasic manner during 24-h treatment ...
Ka-Cheuk Liu, Wei Ge
doaj +1 more source
LHCGR (luteinizing hormone/choriogonadotropin receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on LHCGR (luteinizing hormone/choriogonadotropin receptor), with data on DNA, on the protein encoded, and where the gene is implicated.
Tsai-Morris, CH, Dufau, ML
openaire +3 more sources