Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan+29 more
core +3 more sources
LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling. [PDF]
Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) act on the same receptor (LHCGR) but it is not known whether they elicit the same cellular and molecular response.
Livio Casarini+7 more
doaj +1 more source
Is polycystic ovary syndrome a sexual conflict? A review [PDF]
Several studies have attempted to explain the high overall prevalence of polycystic ovary syndrome among women worldwide (about 4-10%) despite its link to subfertile phenotypes. For this reason, it is considered an evolutionary paradox.
BRIGANTE, Giulia+2 more
core +1 more source
The Libyan jird (Meriones libycus, 1823) is a wild desert rodent that is a seasonal breeder species adapted to breed when the environmental conditions can satisfy the energy and hydrous requirements of pregnant and nursing females to ensure that births ...
Radia Boufermes+3 more
doaj +1 more source
Targeted gene expression profiling in European sea bass (Dicentrarchus labrax, L.) follicles from primary growth to late vitellogenesis [PDF]
7 páginas, 6 figuras, 1 tabla como material suplementario.A real-time PCR-based gene expression survey was performed on isolated European sea bass follicles from primary growth to late vitellogenesis. Expression levels of 18 transcripts with demonstrated
Behmenburg, Clemens+3 more
core +1 more source
The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A+1 more
core +1 more source
Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene
Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males. Despite the pattern of autosomal dominant inheritance, sporadic cases also may occur. Due to activating mutation in luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene, early virilization and advancement in bone age are common with ...
Özcabı, Bahar+7 more
openaire +3 more sources
Familial male-limited precocious puberty due to an activating mutation of the LHCGR: a case report and literature review [PDF]
Familial male-limited precocious puberty (FMPP) is a rare form of gonadotropin-independent precocious puberty that is caused by an activating mutation of the LHCGR gene.
Jihyun Ha+4 more
doaj +1 more source
Hinge region mediates signal transmission of luteinizing hormone and chorionic gonadotropin receptor
Luteinizing hormone-choriogonadotropin receptor (LHCGR), a class A G protein-coupled receptor (GPCR), plays a pivotal role in the maturation of reproductive organs and embryonic development.
Xinheng He+7 more
doaj +1 more source
AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure. [PDF]
Zhang S+18 more
europepmc +3 more sources