Results 51 to 60 of about 11,867 (232)

Pharmacogenomic and structural analysis of constitutive G-protein coupled receptor activity [PDF]

open access: yes, 2007
Premi a l'excel·lència investigadora. Àmbit de les Ciències de la Salut. 2008G-protein coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
Aldo Jongejan   +29 more
core   +3 more sources

LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling. [PDF]

open access: yesPLoS ONE, 2012
Human luteinizing hormone (hLH) and chorionic gonadotropin (hCG) act on the same receptor (LHCGR) but it is not known whether they elicit the same cellular and molecular response.
Livio Casarini   +7 more
doaj   +1 more source

Is polycystic ovary syndrome a sexual conflict? A review [PDF]

open access: yes, 2016
Several studies have attempted to explain the high overall prevalence of polycystic ovary syndrome among women worldwide (about 4-10%) despite its link to subfertile phenotypes. For this reason, it is considered an evolutionary paradox.
BRIGANTE, Giulia   +2 more
core   +1 more source

Assessment of Testicular Lhcgr mRNA Expression Correlated with Testis and Seminal Vesicle Activities in the Libyan jird (Meriones libycus, Rodentia: Muridae) during Breeding Season Compared with Nonbreeding Season

open access: yesAnimals, 2021
The Libyan jird (Meriones libycus, 1823) is a wild desert rodent that is a seasonal breeder species adapted to breed when the environmental conditions can satisfy the energy and hydrous requirements of pregnant and nursing females to ensure that births ...
Radia Boufermes   +3 more
doaj   +1 more source

Targeted gene expression profiling in European sea bass (Dicentrarchus labrax, L.) follicles from primary growth to late vitellogenesis [PDF]

open access: yes, 2011
7 páginas, 6 figuras, 1 tabla como material suplementario.A real-time PCR-based gene expression survey was performed on isolated European sea bass follicles from primary growth to late vitellogenesis. Expression levels of 18 transcripts with demonstrated
Behmenburg, Clemens   +3 more
core   +1 more source

The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]

open access: yes, 2019
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A   +1 more
core   +1 more source

Testotoxicosis: Report of Two Cases, One with a Novel Mutation in LHCGR Gene

open access: yesJournal of Clinical Research in Pediatric Endocrinology, 2015
Testotoxicosis is a rare disorder which presents as isosexual peripheral precocious puberty in males. Despite the pattern of autosomal dominant inheritance, sporadic cases also may occur. Due to activating mutation in luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene, early virilization and advancement in bone age are common with ...
Özcabı, Bahar   +7 more
openaire   +3 more sources

Familial male-limited precocious puberty due to an activating mutation of the LHCGR: a case report and literature review [PDF]

open access: yesAnnals of Pediatric Endocrinology & Metabolism
Familial male-limited precocious puberty (FMPP) is a rare form of gonadotropin-independent precocious puberty that is caused by an activating mutation of the LHCGR gene.
Jihyun Ha   +4 more
doaj   +1 more source

Hinge region mediates signal transmission of luteinizing hormone and chorionic gonadotropin receptor

open access: yesComputational and Structural Biotechnology Journal, 2022
Luteinizing hormone-choriogonadotropin receptor (LHCGR), a class A G protein-coupled receptor (GPCR), plays a pivotal role in the maturation of reproductive organs and embryonic development.
Xinheng He   +7 more
doaj   +1 more source

AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure. [PDF]

open access: goldCell Prolif
Zhang S   +18 more
europepmc   +3 more sources

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