Results 81 to 90 of about 11,867 (232)

Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform

Cell Proliferation, EarlyView.
We compiled a comprehensive set of ZGA genes from mice, humans, pigs, bovines and goats, demonstrating the cross‐species conservation. An interpretable machine learning model, based on k‐mer core features, accurately predicted ZGA genes, revealing abundant and intricate six‐base sequence‐specific patterns and potential binding TFs.
Jixiang Xing, Siqi Yang, Yuchao Liang, Pengwei Hu, Bingjie Dai, Hanshuang Li, Yongqiang Xing, Yongchun Zuo   +7 more
wiley   +1 more source

Unravelling Twin Births in German Holstein Cows: Phenotypic Associations, Genetic Analysis and Potential Underlying Genes and Hormones

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Twin births in dairy cattle are rare but present significant challenges for animal welfare, as both the health of the cow and the calves are affected. This causes economic losses, which prompts breeders to select against twin births and identify associated risk factors.
Laura Hüneke, Hatem Alkhoder, Dierck Segelke, Georg Thaller, Christin Schmidtmann   +4 more
wiley   +1 more source

Genetic Adaptation to Brackish Water and Spawning Season in European Cisco

Molecular Ecology, EarlyView.
ABSTRACT How species adapt to diverse environmental conditions is essential for understanding evolution and the maintenance of biodiversity. The European cisco (Coregonus albula) is a salmonid that occurs in both fresh and brackish water, and this together with the presence of sympatric spring‐ and autumn‐spawning lacustrine populations provides an ...
Qiaoling Deng, Jake Goodall, Mikaela Bergenius Nord, Ignas Bunikis, Arianna Cocco, Bo Delling, Elisabet Einarsdottir, Julia Heintz, Henrik Lantz, Kerstin Lindblad‐Toh, Mai‐Britt Mosbech, Remi‐Andre Olsen, Stefan Palm, Mats E. Pettersson, Martin Pippel, Lucile Soler, Anti Vasemägi, Olga Vinnere Pettersson, Leif Andersson   +18 more
wiley   +1 more source

High‐Fat and High‐Sugar Diet Induces Murine Premature Ovarian Failure by Promoting Mitochondrial Oxidative Phosphorylation Response

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Our study is the first to report the application of scRNA‐seq to analyze the ovarian landscape of HFHS‐fed mice and to verify that the HFHS diet induced POF in mice by activating the oxidative phosphorylation signal transduction pathway in the thecal cell, granulosa cell, and cumulus cell clusters in mouse ovarian tissues.
Kai Li, Yichao Wen, Zeyu Cui, Lele Ling, Chunxia Wang, Bimeng Zhang, Te Liu   +6 more
wiley   +1 more source

Effects of oocyte-derived growth factors on the growth of porcine oocytes and oocyte–cumulus cell complexes in vitro

The Journal of Reproduction and Development, 2021
During oocyte growth and follicle development, oocytes closely communicate with cumulus cells. We examined the effects of oocyte-derived growth factors, growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15), on the growth and ...
Riho MORIKAWA, Jibak LEE, Takashi MIYANO
doaj   +1 more source

A functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production [PDF]

, 2013
Bone morphogenetic proteins (BMP) are firmly implicated as intra-ovarian regulators of follicle development and steroidogenesis. Here we report a microarray analysis showing that treatment of cultured bovine theca cells (TC) with BMP6 significantly (>2 ...
Anand-Ivell, Baird, Bao, Baptiste, Barrie, Bathgate, Bathgate, Bleach, C. Glister, EHRMAN, ERICKSON, Erickson, Fatehi, Feng, Findlay, Fortune, Franks, Gambineri, Glister, Hanna, Hillier, Irving-Rodgers, Ivell, IVELL, J. D. Wade, Knight, Knight, L. Satchell, Livak, Magoffin, Monget, Nef, Nisenblat, P. G. Knight, R. A. D. Bathgate, R. Anand-Ivell, R. Ivell, R. J. Rodgers, Shabanpoor, Shimasaki, Spanel-Borowski, Spicer, Walther, Webber, Wrathall, Y. Dai, Zachow, Zimmermann   +47 more
core   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, Volume 12, Issue 29, August 7, 2025.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Cytogenetic and molecular insight into the genetic background of disorders of sex development in seventeen cats

Scientific Reports, 2022
The genetic background of feline disorders of sex development (DSDs) is poorly understood. We performed comprehensive cytogenetic, molecular, and histological studies of 17 cats with abnormal external genitalia, unusual behavior, or tricolor coats ...
Monika Stachowiak, Izabela Szczerbal, Joanna Nowacka-Woszuk, Tomasz Nowak, Natalia Sowinska, Anna Lukomska, Maciej Gogulski, Malgorzata Badura, Karolina Sklorz-Mencel, Dariusz Jagodka, Wojciech Nizanski, Stanislaw Dzimira, Marek Switonski   +12 more
doaj   +1 more source

Importância do estudo multigénico no diagnóstico molecular de doenças raras por sequenciação de nova geração [PDF]

, 2019
Introdução: A sequenciação de nova geração (NGS) revolucionou o diagnóstico molecular das doenças raras (DR) proporcionando a análise de um maior número de genes, resultados mais rápidos e custos reduzidos. A NGS usando diferentes abordagens, possibilita
Gonçalves, João, Oliveira, Beatriz, Pereira Caetano, Iris, Rodrigues, Pedro, Theisen, Patrícia   +4 more
core  

Hypomethylation‐Triggered SERPINE1 (Serpin Family E Member 1) Exacerbates Polycystic Ovary Syndrome with Hyperandrogenism Induced by Circadian Disruption

MedComm, Volume 6, Issue 7, July 2025.
SERPINE1 shows CpG hypomethylation near its TSS of promoter region when exposed to circadian disruption, and its gene expression triggers hyperandrogenism through the PI3K/AKT pathway. SERPINE1 inhibitor TPX can significantly decrease serum SERPINE1 levels and reduce abnormally high testosterone levels in both continuous darkness‐exposed rats and DHEA ...
Xueying Geng, Weiwei Chu, Shang Li, Xiying Zhou, Dongshuang Wang, Junyu Zhai, Yun Sun, Zi‐Jiang Chen, Yanzhi Du   +8 more
wiley   +1 more source