Results 21 to 30 of about 327 (244)

The many faces of the Liar Paradox

open access: yesPrincipia: An International Journal of Epistemology
The Liar Paradox is a classic argument that creates a contradiction by reflection on a sentence that attributes falsity to itself: ‘this sentence is false’.
José Martínez-Fernández, Sergi Oms
doaj   +1 more source

The Yablo Paradox and Circularity

open access: yesAnálisis Filosófico, 2012
In this paper, I start by describing and examining the main results about the option of formalizing the Yablo Paradox in arithmetic. As it is known, although it is natural to assume that there is a right representation of that paradox in first order ...
Eduardo A. Barrio
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Liar Sentence Mirroring Our Reasoning as Hegel’s Quasi-Speculative Sentence

open access: yesProblemos
This paper explores parallels between the Liar and various aspects of philosophical reasoning. It begins by analyzing the liar sentence, “This sentence is false”, by highlighting its self-referential nature and alternating truth values.
Jae Jeong Lee
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

For a Possible Theory of Lie: the Case of the Alternate History

open access: yesBetween, 2019
The aim of this article is to discuss the logic of the literary genre of the alternate history. In the first paragraph we introduce the problem of the alternate history and its connection with the truth end the lie; here we try to determine a strong ...
Marco Carmello
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On the Possibility of a General Purge of Self-Reference

open access: yesAnálisis Filosófico, 2012
My aim in this paper is to gather some evident in favor of the view that a general purge of self-reference is possible. I do this by considering a modal-epistemic version of the Liar Paradox introduced by Roy Cook.
Lucas Rosenblatt
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

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