Results 221 to 230 of about 823,276 (296)

A Systematic Review to Summarize and Critically Appraise Existing Phenotype Libraries Using Electronic Health Records. [PDF]

Pharmacoepidemiol Drug Saf
Mohammadi S, Campbell C, Sturkenboom MCJM, Vaz TA.   +3 more
europepmc   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Low‐Profile, High‐Gain GRIN RF Lenses via Multi‐Material Vat Photopolymerization

Advanced Functional Materials, EarlyView.
We investigate the opportunity of leveraging multi‐material vat photopolymerization printing to manufacture intricate lenses exhibiting permittivity gradients that can increase signal gain in transmitted radiofrequency signals in the X‐ and Ku‐bands. Lenses produced with more distinct low‐loss materials (up to 5) can deliver an 18 dB signal gain with a
Lawrence Romangsuriat, Alexander Peraire‐Bueno, A. John Hart, Randall M. Erb   +3 more
wiley   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Michele D'Orazio, Biagio Palmisano, Silvia Franco, Arianna Mencattini, Roberta Angelini, Eugenio Martinelli, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +17 more
wiley   +1 more source

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening. [PDF]

Chembiochem
Csorba N, Ábrányi-Balogh P, Orgován Z, Szalai TV, Ferenczy GG, Kollár L, Péczka N, Imre T, Simon J, Szabó P, Schlosser G, Hrast M, Gobec S, Ivanova V, Galdeano C, Kopranovic A, Neumann M, Meyer-Almes FJ, Keserű GM.   +18 more
europepmc   +1 more source

Functional Precision Oncology Approach Using Nanoliter Droplet Array for Drug Sensitivity Testing in Lung Cancer

Advanced Healthcare Materials, EarlyView.
A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian, Vicky L. Schiling, Thomas Muley, Michael Allgäuer, Florian Eichhorn, Michael Meister, Marc A. Schneider, Anna A. Popova   +7 more
wiley   +1 more source

Enhancing Learning Health Systems in Primary and Community Care: Contributions of NHS Library and Knowledge Specialists. [PDF]

Learn Health Syst
Day A, Goswami L.
europepmc   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

Advanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang, Myungji Kim, Hwanyong Choi, Jinseon Park, Minji Kim, Donghwan Kim, Bo Ram Lee, Jinah Jang   +7 more
wiley   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

DIAG: A Framework for Evaluating Whole-Genome Amplification Quality in Single-Cell SNV Analysis. [PDF]

Biology (Basel)
Zhang D, Zhang M, Zhang A, Yang S, Huang W, Cao T, Bu X, Liu Z, Chen B, Deng S.   +9 more
europepmc   +1 more source