Results 71 to 80 of about 25,304,259 (248)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Forsyth Library Bibliographic Instruction Flyer [PDF]

open access: yes, 2016
This color one page document features a Forsyth Library flyer providing information on bibliographic instruction and distance services.https://scholars.fhsu.edu/library_bldg/1095/thumbnail ...
Forsyth Library, Fort Hays State University
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

The Relationship Between Student Demographics and Student Engagement with Online Library Instruction Modules

open access: yesEvidence Based Library and Information Practice, 2016
Objective – To investigate whether there are any demographic trends affecting student engagement with online library instruction which might have implications for practice, the authors designed a case study to examine the relationship between student ...
Mary Thill   +2 more
doaj   +3 more sources

Librarians View Instruction as Integral to Their Professional Identities

open access: yesEvidence Based Library and Information Practice, 2011
Objective – To explore the ways that professional and non-professional library staff experience and relate to their instructional roles. Design – Online survey. Setting – All types of Canadian libraries, including public, school, post-secondary,
Ann Medaille
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The Instructional Library Technician

open access: yes, 2016
Library technicians can be found employed throughout the spectrum of libraries, in a variety of roles. Their education prepares graduates to work both behind the scenes of libraries in cataloguing or with eresources, and in public service roles such as ...
Edwards, Ashley
core   +1 more source

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