Results 31 to 40 of about 1,508,332 (327)

Addressing the tacit knowledge of a digital library system [PDF]

, 2018
Recent surveys, about the Linked Data initiatives in library organizations, report the experimental nature of related projects and the difficulty in re-using data to provide improvements of library services.
Di Iorio, Angela, Schaerf, Marco
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Understanding patterns of library use among undergraduate students from different disciplines [PDF]

, 2014
Objective The objective of this study was to test whether routinely-generated library usage data could be linked with information about students to understand patterns of library use among students from different disciplines at the University of ...
Collins, Ellen, Stone, Graham
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Bibliographic standards and Linked Data. Towards a collaboration between cultural and commercial sectors

JLIS.it, 2013
The Central Institute for the Union Catalogue of Italian Libraries and Bibliographic Information (ICCU) is the National Bibliographic Agency for the coordination and dissemination of international standards and cataloguing rules within Italian libraries.
Patrizia Martini
doaj   +1 more source

Studying Conceptual Models for Publishing Library Data to the Semantic Web [PDF]

, 2017
This thesis studies the library data and the way that linked data technologies may affect libraries. The thesis aims to contribute to the research regarding the devel-opment and implementation of a framework for the integration of bibliographic data in ...
R Smiraglia, S Strodl, S Zapounidou, S Zapounidou, S Zapounidou, V Ogle   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Relationship status: libraries and linked data in Europe [PDF]

, 2018
Libraries shared metadata long before the advent of the Internet by utilising standards such as MARC and AACR to enable interoperability (Tallerås, 2013). A difficulty with their use in the networked environment has been the inability to exchange data at scale, due to the diversity of descriptive standards and schemas adopted as well as the diversity ...
Rasmussen Pennington, Diane, Cagnazzo, Laura   +1 more
openaire   +2 more sources