Results 51 to 60 of about 446,883 (238)
Diffusion and adoption of Linked Data among libraries
Proceedings of the Association for Information Science and Technology, 2020 AbstractThrough content analyses of literature about the Linked Data (LD) adoption of individual libraries, this study found that the diffusion of LD among libraries is a decentralized process with high‐degree of reinvention and a continuous process that includes multiple stages and might last for many years.
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Semantic technologies and linked data for the Italian PA: the case of data.cnr.it
JLIS.it, 2013 Governmental data are being published in many countries, providing an unprecedented opportunity to create innovative services and to increase societal awareness about administration dynamics.
Aldo Gangemi
doaj +6 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The role of libraries in Linked Data
, 2021 Objetivo: As bibliotecas possuem um papel importante na organização de recursos informacionais, sendo pioneiras no desenvolvimento de formatos e padrões que garantem a representação e recuperação desses recursos, e tem constantemente se atualizado para acompanhar os avanços tecnológicos, como o estabelecimento do ambiente Web e do Linked Data, um ...
Jesus, Ananda Fernanda de +2 more
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Linked Open Data for Libraries
, 2011 Presentation given at NVB 2011 Conference, The Netherlands.
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