Results 71 to 80 of about 491,826 (279)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Linking Library Metadata to the Web: the German Experiences

open access: yesJLIS.it, 2013
One of the major challenges of libraries today is to make metadata available for the usage and re-usage by researchers and the scientific community. Therefore it is necessary to open the cataloguing systems for non-restricted and completely free access.
Gabriele Meßmer
doaj   +6 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Library Data: From Linked Data to the Research Landscape [PDF]

open access: yes, 2018
Presented at the ARC18 OCLC Americas Regional Council Conference held in Chicago, Illinois on October 25-26, 2018.Presented in collaboration with MacKenzie Smith (University of California, Davis) as part of the "Library Data: From Linked Data to the ...
Mocnik, Joe
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Library Linked Data - Technologien, Projekte, Potentiale [PDF]

open access: yes, 2011
The Semantic Web, Library Linked (Open) Data and its impact on libraries has recently become a popular and much discussed topic. The aim of this article is to provide a concise overview of these concepts and to point out some use cases for the Austrian ...
Krabo, Ulrike, Knitel, Markus
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Linked data: un nuovo alfabeto del web semantico

open access: yesJLIS.it, 2013
The paper defines the linked data as a set of best practices that are used to publish data on the web using a machine; the technology (or mode of realization) of linked data is associated with the concept of the semantic web.
Mauro Guerrini, Tiziana Possemato
doaj   +1 more source

Library Linked Data Incubator Group: Review of the Final Report [PDF]

open access: yes, 2011
These slides are a distillation of the Final Report issued by the W3C Library Linked Data Incubator Group. This presentation was delivered on 15Dec2011 at a meeting of the Linked Data Interest Group at York University and intended to facilitate ...
Knight, F. Tim
core  

Processing Linked Data with Catmandu

open access: yes, 2014
Introduction into library data processing with help of ...
Hochstenbach, Patrick   +1 more
core   +1 more source

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