Results 71 to 80 of about 1,514,650 (322)

Le iniziative del FRBR Review Group e il mondo Linked data

open access: yesJLIS.it, 2013
The FRBR Review Group has the mandate to review and maintain IFLA's family of conceptual models and to develop guidelines and interpretive documents to assist in the application of the models.
Pat Riva
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Linked Data at the Spanish National Library and the application of IFLA RDFS models [PDF]

open access: yes, 2011
The Spanish National Library (Biblioteca Nacional de España1. BNE) and the Ontology Engineering Group2 of Universidad Politécnica de Madrid are working on the joint project ?Preliminary Study of Linked Data?, whose aim is to enrich the Web of Data with ...
Escolano Rodríguez, Elena   +1 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Linking Library Metadata to the Web: the German Experiences

open access: yesJLIS.it, 2013
One of the major challenges of libraries today is to make metadata available for the usage and re-usage by researchers and the scientific community. Therefore it is necessary to open the cataloguing systems for non-restricted and completely free access.
Gabriele Meßmer
doaj   +6 more sources

Transforming Technical Services: Evolving Functions in Large Research University Libraries [PDF]

open access: yes, 2016
Technical services functions in academic libraries have evolved in response to fiscal pressures and advances in technology. In this study the author investigates how technical services in large research university libraries are adapting to support the ...
Davis, Jee
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Temas de Biblioteconomía: Suministro de información: servicios de referencia y búsquedas bibliográficas. Formación de usuarios en las bibliotecas universitarias. [PDF]

open access: yes, 2009
This paper renders an overview on the library reference service and its new trends. It goes on to deal with bibliographic searches and overlooks some basic questions of data bases, searching tools and data recovery strategies.
Martín-Gavilán, César
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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