Results 61 to 70 of about 471,934 (239)
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
Review of E. T. Mitchell’s Library Linked Data (Library Technology Reports, Vol. 52)
Journal of New Librarianship, 2017 Review of Mitchell, E.T. (2016). Library Technology Reports: Vol. 52: Library linked data: Early activity & development. Library Technology Reports 52(1). Chicago, IL: American Library Association.
Dallas Long
doaj +1 more source
Modelling Library Linked Data In Practice
, 2015 In this paper we present reflections and recommendations concerning the conversion of library metadata into Linked Data. We will briefly describe the different data models that exist for this purpose and argue their strengths and weaknesses with a special focus on the entification issue, before illustrating this problem with the description of three ...
Prongué, Nicolas , Schneider, René
openaire +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Linked Heritage Experience in Linking Heritage Information
JLIS.it, 2013 The Linked Heritage Project started in April 2011. It is funded by the European Commission under the IST Policy Support Programme (ICT PSP), and runs for 30 months.
Gordon McKenna
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
JLIS.it, 2013 Interoperability today is the key term for the enhancement of databases published on the web: the data, when isolated, have little value, on the contrary, their value increases significantly when different datasets, produced and published independently ...
Tommaso Agnoloni +4 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Linked Data for Libraries (LD4L): Expanding the Linked Data Ecosystem
, 2016 The Linked Data for Libraries (LD4L) team, consisting of librarians, ontologists, metadata experts, and developers from Cornell, Harvard, and Stanford libraries with support from the Andrew W. Mellon Foundation, has recently completed its first two years of work on adapting and developing LOD standards for describing and sharing information about ...
openaire +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source