Results 81 to 90 of about 1,478,126 (315)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Об объекте и предмете библиотековедческих исследований
Библиосфера, 2010 The authors treat different approaches to the definition of object and subject in library science investigations, offer their own definition of the notion «the object of library science investigation» as a library process and come to the conclusion, that
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
О ПРИНЦИПЕ ИСТОРИЗМА И ИСТОРИЧЕСКОМ ПОДХОДЕ В БИБЛИОТЕЧНЫХ ИССЛЕДОВАНИЯХ
Библиосфера, 2010 An analysis of methodological problems connected with the use of the principle of historicism and the historic approach to library research is ...
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Наукометрический анализ отечественного библиотековедения и библиографоведения
Библиосфера, 2010 Based on quantitative analysis of protected doctoral theses, journals, conferences, reflecting the results of scientific research, the availability of scientific leaders and journals with sufficient impact factor unfavorable conclusions on the state of ...
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FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
Концепции медиареальности как теоретико-методологическая основа библиотековедческой реальности
Библиосфера, 2010 Problems of mediareality in the field of library science are considered. The notion «reality» as a general theoretical basis for the study of library activity is analyzed. The notion of «library science reality» is revealed.
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