Results 81 to 90 of about 5,966,058 (289)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Improvement of financial support entreprenerial activity

Ученые записки Российской академии предпринимательства, 2021
In the article questions and problems of providing with available and acceptable financial (credit) resources (means) of entrepreneurs and enterprise structures, dynamics of the key interest rates established by the regulator, the interest(credit) rates ...
L. A. Akhmetov, D. A. Zuravlev
doaj  

A new fireworm (Amphinomidae) from the Cretaceous of Lebanon identified from three-dimensionally preserved myoanatomy [PDF]

, 2015
© 2015 Parry et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in ...
A Filippova, A Filippova, A Tzetlin, A Tzetlin, AA Hay, C Helm, D Eibye-Jacobsen, D Eibye-Jacobsen, D Grimaldi, Dan Sykes, DEG Briggs, E Borda, F Pleijel, G Bracchi, G Purschke, G Purschke, G Rouse, GE Budd, Gregory D. Edgecombe, GW Rouse, H Hausen, I Thompson, J Vinther, J Vinther, Jakob Vinther, JR Marsden, JR Marsden, L Feldkamp, L Parry, L Parry, Luke A. Parry, M Imajima, M Müller, MD Sutton, P Chellouche, Paul Wilson, PH Bitter von, PR Wilby, S Conway Morris, S Conway Morris, U Farrell   +40 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Administrative means for legal protection of beaches - Study in Algerian legislation-Local Public Service Delegation as an effective local financing mechanism under Presidential Decree 15-247. [PDF]

مجلة الاجتهاد للدراسات القانونية والاقتصادية, 2019
Algeria is a natural and human power. It has been blessed by a long coastline of 1644 km. It is of strategic importance in various economic fields: tourist and industrial, natural and human resources where the majority of the population is gathered, and ...
Tekarri Haifa Rachida
doaj  

Leaf venation networks of Bornean trees: images and hand-traced segmentations. [PDF]

, 2019
The data set contains images of leaf venation networks obtained from tree species in Malaysian Borneo. The data set contains 726 leaves from 295 species comprising 50 families, sampled from eight forest plots in Sabah. Image extents are approximately 1 ×
Blonder, Benjamin, Both, Sabine, Burslem, David, Jodra, Miguel, Majalap, Noreen, Malhi, Yadvinder, Teh, Yit   +6 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The role of licenses in public utility services provision – 19th century experiences

Studia Historiae Oeconomicae, 2016
The subject of this article is a part of a broader debate related to the participation of the private sector in the execution of public services. It concerns those services which are provided to recipients in the conditions of a natural monopoly, based ...
Elżbieta Adamczyk
doaj   +1 more source

PATENT LICENSING BY MEANS OF AN AUCTION: INTERNAL VS. EXTERNAL PATENTEE [PDF]

, 1993
An independent research laboratory owns a patented process innovation that can be licensed by means of an auction to two Cournot duopolists producing differentiated goods.
BF Green, E Gombrich, F Attneave, F Dubery, H Rhingold, M Chen, R Cowie, R Cowie   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source